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Clinical Study on Effect of Garlicin in Stabilizing the Carotid Artery atherosclerotic plaque in Patients with Primary Hypertension and Coronary Artery Disease

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Chinese Journal of Integrative Medicine 2006年第3期12卷 166-170页

作者：程文立柯元南史载祥王瑛陈莉鞠镐范书英 Department of National Integrative Medicine Center for Cardiovascular Diseases China-Japan Friendship HospitalBeijing (100029)

Objective： To investigate the effect of garlicin in treating carotid artery atherosclerotic plaque （OAAP） in patients with primary hypertension and coronary heart disease （PHT-OHD）. Methods： Seventynine patients with PHT-OHD were randomly divided into the treated group （39 patients） treated with garlicin and fosinopril and the control group （40 patients） treated with fosinopril alone. The change of OAAP was evaluated by high frequency ultrasonic examination every six months, and the changes of intercellular adhesion molecule-1 （IOAM-1） and high sensitive O-reactive protein （hs-ORP） were measured by ELISA, with the observation proceeding for 52 weeks totally. Results： By the end of the experiment, the number of complex plaques, Orouse integrals, intima-media thickness, serum IOAM-1 and hs-ORP were significantly lower in the treated group than those in the control group with significant difference （P〈0.05）. Conclusion： Garlicin could stabilize CAAP to a certain extent and shows a definite vascular protective effect in patients with PHT-CHD.

关键词： garlicin primary hypertension coronary heart disease atherosclerotic plaque intercellular adhesion molecule-1 high sensitive C-reactive protein

Comparison of the Values of MRI in the Differential Diagnosis of Symptomatic Carotid Stenosis and atherosclerotic plaque

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Proceedings of Anticancer Research 2020年第4期4卷 1-4页

作者： Junying Bi Yanni Zeng Jun Meng Tiantian Zhou Xiang Gao Hubei No.3 People's Hospital of Jianghan University(Zhongshan Hospital of Hubei Province affiliated to Jianghan University) Wulian 430033.Hubei ProvinceChina

Objective:To evaluate the values of Carotid Magnetic Resonance Imaging(MRI)in the differential diagnosis of symptomatic carotid stenosis and atherosclerotic ***:56 patients with ischemic cerebrovascular disease admitted in our hospital from October 2018 to October 2019 were selected and treated with Carotid MRI and digital subtraction angiography(DSA)*** to the two examination results recorded and the“gold standard”of DSA examination,values of Carotid MRI in the differential diagnosis of symptomatic carotid stenosis were ***:According to the“gold standard”of DSA examination,the sensitivity and specificity of MRI examination for carotid stenosis were:Mild:92.54%and 97.78%;Moderate:85.71%and 88.78%;Severe:100.00%and 97.8%;and complete occlusion:100.00%and 100.00%;The proportions of intraplaque haemorrhage and ruptured fibrous cap in different degrees of carotid artery stenosis were:Mild:30.16%and 22.22%;Moderate:43.48%and 39.13%;And severe:57.89%and 52.63%.Conclusion:MRI examination can evaluate the degree of symptomatic carotid artery stenosis,and show the characteristics of atherosclerotic plaque at the same time to provide a reference for early clinical differential diagnosis and treatment.

关键词： Symptomatic carotid stenosis atherosclerotic plaque MRI

Evaluation of ^(99m)Tc Labeled Diadenosine Tetraphosphate as an atherosclerotic plaque Imaging Agent in Experimental Models

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2006年第3期26卷 278-280页

作者：曹卫张永学安锐 Department of Nuclear Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

The potential of ^99mTc labeled P^1, P^4-di （adenosine-5 ＇）-tetraphosphate （Ap4A） for imaging experimental atherosclerotic plaques was evaluated in New Zealand white （NZW） rabbits. To label the ^99mTc to Ap4A, stannous tartrate solution was used. ^99mTc-Ap4A was purified on a Sephadex G-25 column. The radiochemistry purities of ^99mTc-Ap4A were 85% to 91%. Biodistribution study revealed ^99mTc-Ap4A cleared from blood rapidly. Thirty min after ^99mTc-Ap4A administrated on NZW atherosclerotic rabbits, lesion to blood （target/blood, T/B） ratio was 3. 17 ±1.27, and lesions to normal （target/non-target, T/NT） ratio was 5.23 ±1.87. Shadows of atherosclerotic plaques were clearly visible on radioautographic film. Aortas with atherosclerotic plaques also could be seen on ex vivo gamma camera images. atherosclerotic abdominal aortas were clearly visible on in vivo images 15 min to 3 h after ^99mTc-Ap4A administration. ^99mTc-labeled Ap4A can be used for rapid noninvasive detection of experimental atherosclerotic plaque.

关键词： technetium diadenosine tetraphosphate atherosclerotic plaque radionuclide imaging

Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases

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Neural Regeneration Research 2020年第10期15卷 1807-1813页

作者： Jun-Mou Hong Yi-Da Hu Xiao-Qing Chai Chao-Liang Tang Department of Vascular Surgery Zhongshan HospitalXiamen UniversityXiamenFujian ProvinceChina Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Activin receptor-like kinase 1(ALK1)is a transmembrane serine/threonine receptor kinase of the transforming growth factor beta(TGFβ)receptor ***1 is specifically expressed in vascular endothelial cells,and its dynamic changes are closely related to the proliferation of endothelial cells,the recruitment of pericytes to blood vessels,and functional differentiation during embryonic vascular *** pathophysiology of many cerebrovascular diseases is today understood as a disorder of endothelial cell function and an imbalance in the proportion of vascular ***,mutations in ALK1 and its co-receptor endoglin are major genetic risk factors for vascular arteriovenous *** studies have shown that ALK1 is closely related to the development of cerebral aneurysms,arteriovenous malformations,and cerebral *** this review,we describe the various roles of ALK1 in the regulation of angiogenesis and in the maintenance of cerebral vascular homeostasis,and we discuss its relationship to functional dysregulation in cerebrovascular *** review should provide new perspectives for basic research on cerebrovascular diseases and offer more effective targets and strategies for clinical diagnosis,treatment,and prevention.

关键词： activin receptor-like kinase 1 aneurysm atherosclerotic plaque endoglin extracellular matrix protein intracranial arteriovenous malformation matrix metalloproteinase pericyte transforming growth factor beta 1 pathway vascular development

Magnetic Resonance Imaging of atherosclerotic Lesion with New Devised Animal Surface Coil

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Journal of Shanghai Jiaotong university(Science) 2008年第6期13卷 748-752页

作者：赵炳辉李明华赵清程英升肖云峰赵家民 Radiology Department Shanghai 6th People's HospitalShanghai Jiaotong UniversityShanghai 200233China Cardiology Department Shanghai 6th People's Hospital Shanghai Jiaotong UniversityShanghai 200233China Shanghai Chenguang Medical Technology Company Shanghai 200233China

The ability of dynamic contrast enhanced magnetic resonance imaging(DCE MRI) with a new devised animal surface coil was analyzed in identifying atherosclerotic plaques in the rabbit medium-sized iliac artery(IA).Then a comparative analysis of multi-detector computed tomography(MDCT) and DCE MRI was done in discerning morphology and components of 80 atherosclerotic plaques identified by *** shows that the DCE MRI may be an emerging noninvasive and economic way to characterize atherosclerotic plaques at ***'s more, a new devised animal surface coil would further improve the signal-to-noise ratio(SNR) and the quality of ***, CT angiography(CTA) may be better than MR angiography(MRA) in detecting vessel stenosis.

关键词： surface coil magnetic resonance imaging multi-detector CT atherosclerotic plaque

Role of glycolysis in diabetic atherosclerosis

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World Journal of Diabetes 2023年第10期14卷 1478-1492页

作者： Qian-Jia Liu Wei Yuan Ping Yang Chen Shao Department of Cardiology Affiliated Hospital of Jiangsu UniversityZhenjiang 212000Jiangsu ProvinceChina

Diabetes mellitus is a kind of typical metabolic disorder characterized by elevated blood sugar ***(AS)is one of the most common complications of *** lifestyles and trends that promote overconsumption and unhealthy practices have contributed to an increase in the annual incidence of diabetic AS worldwide,which has created a heavy burden on *** studies have shown the significant effects of glycolysis-related changes on the occurrence and development of diabetic AS,which may serve as novel therapeutic targets for diabetic AS in the *** is an important metabolic pathway that generates energy in various cells of the blood vessel *** particular,it plays a vital role in the physiological and pathological activities of the three important cells,Endothelial cells,macrophages and vascular smooth muscle *** are lots of similar mechanisms underlying diabetic and common AS,the former is more *** this article,we describe the role and mechanism underlying glycolysis in diabetic AS,as well as the therapeutic targets,such as trained immunity,microRNAs,gut microbiota,and associated drugs,with the aim to provide some new perspectives and potentially feasible programs for the treatment of diabetic AS in the foreseeable future.

关键词： atherosclerotic plaque Hyperglycemia Trained immunity microRNAs Gut microbiota Drugs

Non-invasive assessment of intracranial wall shear stress using high-resolution magnetic resonance imaging in combination with computational fluid dynamics technique

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Fundamental Research 2022年第2期2卷 329-334页

作者： Yuwen Chen Jia Liu Mingli Li Yannan Yu Zhengzheng Yan Wenshin Shiu Bokai Wu Zaiheng Cheng Yao Meng Yang Liu Weizhuang Yuan Zongmuyu Zhang Weihai Xu Department of Neurology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical Cllege HospitalChinese Academy of Medical Sciences and Peking Union Medical College1 ShuaifuyuanBeijing 100005China Department of Cardiology Second Afliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China Shenzhen Instiutes of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Shenzhen Key Laboratory for Exascale Engineering and Scientific Computing Shenzhen 518055China Department of Radiology Peking Union Medical College HospitalChinese Acadermy of Medical Sciences1 ShuaifiryuanBeijing 100005China Department of Radiology Stanford UniversityCaliformia 94305United States Department of Neurology Saarland UniversityKirrberger StraSe 66421Germany

In vivo studies on association between wall shear stress(WSS)and intracranial plaque are *** on the three-dimensional T1-weighted high-resolution magnetic resonance imaging(3DT1 HR-MRI)data of patients with low-grade stenotic(atherosclerotic middle cerebral artery(MCA)and subjects with normal MCA,we built a three-dimensional reconstructed WSS model by computational fluid dynamics(CFD)***-dimensional registration of the CFD model to the HR-MRI was performed with projections based on the resolution and thickness of the *** relationships between the Wss at each side of the vessel wall and plaque location were analyzed.A total of 94 MCA plaques from 43 patients and 50 normal MCAs were *** the normal MCAs,WSS was lower at the ventral-inferior wall than at the dorsal-superior wall(proximal segment,patherosclerotic MCAs,similar low Wss regions were observed where plaques *** WSS ratio of the ventral-inferior wall to the dorsal-superior wall in atherosclerotic MCAs was lower than that in normal MCAs(p=0.002).The WSS_(inmer-outer)ratio in atherosclerotic MCAs was lower than that in normal MCAs(p=0.002).Low WSS was associated with MCA atherosclerosis formation and occurred mainly at the ventral inferior wall,which was anatomically opposite the orifices of penetrating arteries,and at the inner wall of the MCA ***,the results were well consistent with the low WSS theory in atherosclerosis *** reconstructed WSS model is a promising novel method for assessing an individualized vascular profile once validated by further studies.

关键词： Intracranial atherosclerosis Wall shear stress atherosclerotic plaque High-resolution magnetic resonance imaging Computational fluid dynamics

High-density lipoproteins:an emerging target in the prevention of cardiovascular disease

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Cell Research 2006年第10期16卷 799-808页

作者： Belinda A Cutri Neil J Hime Stephen J Nicholls The Heart Research Institute CamperdownSydneyNSW 2050Australia Department of Immunology The Scripps Research InstituteLa JollaCA 92037USA Department of Cardiovascular Medicine The Cleveland Clinic FoundationMail Code JJ659500 Euclid AvenueClevelandOH 44195USA

High-density lipoproteins (HDLs) have been well established to protect against the development of atheroscleroticcardiovascular *** has become apparent that in addition to the promotion of reverse cholesterol transport,HDLspossess a number of additional functional properties that may contribute to their beneficial influence on the arterial wall.A number of exciting therapeutic strategies have been developed that target HDL and its ability to protect against thedevelopment of atherosclerotic *** paper will review how the promotion of the functional properties of HDLinhibits the formation of atherosclerotic plaque and stabilises lesions in patients with established disease.

关键词： high-density lipoproteins cardiovascular disease atherosclerotic plaque stabilises lesions

Machine learning for diagnosis of coronary artery disease in computed tomography angiography:A survey

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Artificial Intelligence in Medical Imaging 2020年第1期1卷 31-39页

作者： Feng-Jun Zhao Si-Qi Fan Jing-Fang Ren Karen M von Deneen Xiao-Wei He Xue-Li Chen School of Information Science and Technology Northwest UniversityXi’an 710069Shaanxi ProvinceChina Xi’an Key Lab of Radiomics and Intelligent Perception Northwest UniversityXi’an 710069Shaanxi ProvinceChina Engineering Research Center of Molecular and Neuro Imaging Ministry of EducationSchool of Life Science and TechnologyXidian UniversityXi’an 710126Shaanxi ProvinceChina

Coronary artery disease(CAD)has become a major illness endangering human *** mainly manifests as atherosclerotic plaques,especially vulnerable plaques without obvious symptoms in the early *** a rupture occurs,it will lead to severe coronary stenosis,which in turn may trigger a major adverse cardiovascular *** tomography angiography(CTA)has become a standard diagnostic tool for early screening of coronary plaque and stenosis due to its advantages in high resolution,noninvasiveness,and three-dimensional ***,manual examination of CTA images by radiologists has been proven to be tedious and time-consuming,which might also lead to intra-and interobserver ***,many machine learning algorithms have enabled the(semi-)automatic diagnosis of CAD by extracting quantitative features from CTA *** paper provides a survey of these machine learning algorithms for the diagnosis of CAD in CTA images,including coronary artery extraction,coronary plaque detection,vulnerable plaque identification,and coronary stenosis *** included articles were published within this decade and are found in the Web of *** wish to give readers a glimpse of the current status,challenges,and perspectives of these machine learning-based analysis methods for automatic CAD diagnosis.

关键词： Machine learning Deep learning Coronary artery disease atherosclerotic plaque Vulnerability Stenosis Segmentation Computed tomography angiography