检索结果-南通市图书馆

Prevalence of and risk factors for aspirin resistance in elderly patients with coronary artery disease

Journal of Geriatric Cardiology 2013年第1期10卷 21-27页

作者： Xian-Feng Liu Jian Cao Li Fan Lin Liu Jian Li Guo-Liang Hu Yi-Xin Hu Xiao-Li Li First Geriatric Cardiology Division of South Building Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China

Objective To assess the prevalence of and related risk factors for aspirin resistance in elderly patients with coronary artery disease (CAD). Methods Two hundred and forty-six elderly patients (75.9 ±7.4 years) with CAD who received daily aspirin therapy (≥75 mg) over one month were recruited. The effect of aspirin was assessed using light transmission aggregometry (LTA) and thrombelastography platelet mapping assay (TEG). aspirin resistance was defined as ≥20% arachidonic acid (AA)-induced aggregation and ≥70% adenosine diphosphate (ADP)-induced aggregation in the LTA assay. An aspirin semi-responder was defined as meeting one (but not both) of the criteria described above. Based on the results of TEG, aspirin resistance was defined as ≥50% aggregation induced by AA. Results As determined by LTA, 23 (9.3%) of the elderly CAD patients were resistant to aspirin therapy; 91 (37.0%) were semi-responders. As determined by TEG, 61 patients (24.8%) were aspirin resistant. Of the 61 patients who were aspirin resistant by TEG, 19 were aspirin resistant according to LTA results. Twenty-four of 91 semi-responders by LTA were aspirin resistant by TEG. Multivariate logistic regression analysis revealed that elevated fasting serum glucose level (Odds ratio: 1.517; 95% CI: 1.176–1.957; P = 0.001) was a significant risk factor for aspirin resistance as determined by TEG. Conclusions A significant number of elderly patients with CAD are resistant to aspirin therapy. Fasting blood glucose level is closely associatedwith aspirin resistance in elderlyCAD patients.

关键词： aspirin resistance Coronary artery disease Risk factors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association of the Platelet Membrane Glycoprotein Ⅰa C807T Gene Polymorphism with aspirin resistance

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第6期27卷 664-667页

作者：苏冠华王朝晖丁艳萍刘晓倩王珏 Department of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Department of Cardiology the Third Affiliated Hospital He'nan University of Science and Technology The Second Clinical college Tongji Medical College Huazhong University of Science and Technology

To explore the correlation between the C807T polymorphism of platelet membrane glycoprotein Ⅰa （GP Ⅰa） gene and aspirin resistance in Chinese people, 200 patients with high-risk of atherosclerosis took aspirin （100 mg/d） for 7 days. Platelet aggregation function was detected using adenosine diphosphate （ADP） and arachidonic acid （AA） before and after the administration of aspirin. Then the subjects were divided into three groups according to the results of platelet aggregation function： an aspirin resistant （AR） group, an aspirin semi-responder （ASR） group and an aspirin-sensitive （AS） group. Platelet GP Ⅰa gene 807CT polymorphism was examined by means of polymerase chain reaction-sequence specific primers （PCR-SSP）. The results showed that T allelic frequency in AR group and ASR group were higher that of AS group （P〈0.005）, and the prevalence of genotypes （TT＋TC） of these two groups was significantly higher than that in AS group （P〈0.05）. Platelet GP Ⅰa T allele was significantly associated with aspirin resistance as revealed by multiple logistic regression （OR=3.76, 95% CI： 2.87-9.58）. The results suggest that inherited platelet GP Ⅰa variations may have an important impact on aspirin resistance and the presence of GP Ⅰa T allele may be a marker of genetic susceptibility to aspirin resistance.

关键词： platelet membrane glycoprotein aspirin resistance genetic polymorphism atherosclerosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

引用

Journal of Clinical and Nursing Research 2022年第1期6卷 15-21页

作者： Yuxi Shi Hongmei Ding Deqin Geng Xuzhou Medical University Xuzhou 221002Jiangsu ProvinceChina Department of Neurology Zhongwu Hospital of Suqian CitySuqian 223800Jiangsu ProvinceChina Affiliated Hospital of Xuzhou Medical University Xuzhou 221002Jiangsu ProvinceChina

Objective:To study the related factors of aspirin resistance(AR)in acute ischemic stroke.Methods:A total of 138 patients with acute ischemic stroke treated in hospital affiliated to Xuzhou medical university from August 2016 to August 2018 were the study subjects,examine his medical data from the past.They were divided into the AR group(40 cases)and the non-AR group(98 cases)according to whether AR appears.Gender,disease history,biochemical indicators and etc.were compared between the two groups.The independent risk factors of AR were investigated using univariate analysis and logistic regression analysis.Results:40 cases of AR occurred in 138 patients,with an incidence rate of 28.99%.Diabetes,platelet count(PLT),microRNA-19a(m iR-19a)expression,smoking,high-sensitivity C-reactive protein(hs-CRP),Low-density lipoprotein cholesterol(LDL-C),fibrinogen(FIB)and age difference between the AR group and non-AR group was statistically significant(P0.05).Logistic regression analysis showed that the independent risk factors for AR in acute ischemic stroke were diabetes(OR=2.773,95%CI:1.102~5.065,P=0.025),miR-19a(OR=3.021,95%CI:1.322~6.545,P=0.021),hs-CRP(OR=2.719,95%CI:1.301~5.022,P=0.028)and smoking(OR=1.983,95%CI:1.114~3.887,P=0.040).Conclusion:The incidence of AR is higher in acute ischemic stroke.Risk factors include diabetes,miR-19a expression,hs-CRP,smoking,etc.Clinical intervention measures can be taken to reduce the risk of AR and improve acute ischemic stroke prognosis.

关键词： Acute ischemic stroke aspirin resistance Related factors Diabetes MicroRNA-19a High-sensitivity C-reactive protein Smoking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interaction among COX-2, P2Y1 and GPⅢa gene variants is associated with aspirin resistance and early neurological deterioration in Chinese stroke patients Running title: Genetic variants and aspirin resistance ischemic stroke

Interaction among COX-2, P2Y1 and GPⅢa gene variants is ass...

引用

四川省医学会第十五次精神病学学术会议暨第三次心身医学学...

Objective: The association of genetic variants with aspirin resistance（AR） remains controversial. The aim of this study was to assess the correlation of relevant genetic variants with AR and early clinical outcomes in Chinese patients with acute ischemic stroke（IS）. Methods: Eight hundred and fifty acute IS patients were consecutively enrolled. Platelet aggregation activity was measured before and after a 7-10 day aspirin treatment. The DNA sequences of 14 variants of COX-1, COX-2, GPIb, GPIIIa, P2Y1 and P2Y12 genes were examined using a matrix-assisted laser desorption/ionization time of flight mass spectrometry. Gene-gene interactions were analyzed using generalized multifactor dimensionality reduction（GMDR）. The primary outcome was early neurological deterioration（END） within the first 10 days after admission.The secondary outcome was a composite of early recurrent ischemic stroke（ERIS）, myocardial infarction（MI）, and death during the first 10 days after admission. Results: Among the 850 acute IS patients, 175（20.6%） had AR, 45（5.3%） had aspirin semi-resistance（ASR）, 121（14.2%） developed END, 17（0.2%） had ERIS, 2（0.2%） died, and 6（0.7%） had MI. Apart from rs1371097 variant, there were no associations between other variants and AR using the single locus analysis. However, GMDR analysis demonstrated there was significant gene-gene interaction among rs20417, rs1371097, and rs2317676 with rs20417 CC, rs1371097 TT, and rs2317676GG;rs20417 CC, rs1371097 TT, and rs2317676GG/AG;rs20417 CC, rs1371097 CT, and rs2317676 AG the high-risk interactions for AR in IS patients. The frequency of END was significantly higher in patients with AR and carrying high-riskinteractive genotypes. Moreover, AR and high-risk interactive genotypes were independently associated with END. Conclusion: Sensitivity of IS patients to aspirin and END may be multifactorial and is not determined by single gene polymorphisms. The combinational analysis used in this study may provide further insight into the complex genetic risk of AR.

关键词： Ischemic stroke aspirin resistance genetic variants polymorphism early neurological deterioration

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Earlier application of loading doses of aspirin and clopidogrel decreases rate of recurrent cardiovascular ischemic events for patients undergoing percutaneous coronary intervention

引用

Chinese Medical Journal 2012年第4期125卷 631-638页

作者： Tang Fa-kuan Lin Le-jian Hua Ning Lu Hong Qi Zhi Tang Xue-zheng Chinese Peoples Liberat Army Hosp 309 Dept Cardiol Beijing 100091 Peoples R China

Background aspirin and clopidogrel resistance plays a significant role in the development of cardiovascular ischemic events for ninety patients undergoing percutaneous coronary intervention.Recent studies have indicated that increasing the dose of antiplatelet drugs maybe a potent method to improve the inhibition of platelet aggregation.Methods Thrombelastograph （TEG） determinations were used to evaluate the effect of antiplatelet therapy.According to the results,90 patients were divided into three groups and given different doses of aspirin and clopidogrel.Thirty patients with both an inhibition rate of aspirin 〉50% and an inhibition rate of clopidogrel 〉50% were defined as the control group.Sixty patients with an inhibition rate for aspirin 〈50% and an inhibition rate for clopidogrel 〈50% were defined as the resistance group.Patients in resistance group were randomly assigned to be given a routine dose （100 mg aspirin plus 75 mg clopidogrel per day,which we called a resistance plus routine dose group,R＋R） and a loading dose （200 mg aspirin and 150 mg clopidogrel per day,which we called resistance plus loading dose group,R＋L） of antiplatelet therapy.A 12-month follow-up was observed to examine the change of inhibition rate of antiplatelet therapy and to estimate the relationship between inhibition rate and the occurrence of cardiovascular ischemic events.Results After 6 months of antiplatelet therapy,the inhibition rate of aspirin in the R＋L group increased from （31.4±3.7）% to （68.6±7.1）%,which was significantly higher than that in R＋R group,（51.9±8.2）% （P 〈0.01）.The inhibition rate of clopidogrel in the R＋L group increased from （22.1±3.8）% to （60.2±7.4）%,which was significantly higher than in the R＋R group,（45.9±4.3）% （P 〈0.01）.The occurrence rates of cardiovascular ischemic events,stent thrombosis,recurrent unstable angina and myocardial infarction in the R＋R group were 20%,36% and 17%,respectively.Occurrence was significantly increased compared with that in the control group,3%,10% and 1%,respectively （P 〈0.0

关键词： aspirin resistance clopidogrel resistance thrombelastograph percutaneous coronary intervention cardiovascular ischemic events

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clopidogrel improves aspirin response after off-pump coronary artery bypass surgery

引用

The Journal of Biomedical Research 2014年第2期28卷 108-113页

作者： Xuezhong Wang Xiaoxuan Gong Tiantian Zhu Qiu Zhang Yangyang Zhang Xiaowei Wang Zhijian Yang Chunjian Lia Department of Cardiology the First Affiliated HospitalNanjing Medical University Department of Cardiology Maanshan people's Hospital Department of Cardiology Jiangning People's Hospital Department of Cardiology the Second People's Hospital of Changzhou City Department of Cardiac-thoracic Surgery the First Affiliated HospitalNanjing Medical University

We sought to assess the incidence of aspirin resistance after off-pump coronary artery bypass （OPCAB） surgery, and investigate whether clopidogrel can improve aspirin response and be safely applied early after OPCAB surgery. Sixty patients who underwent standard OPCAB surgery were randomized into two groups. One group （30 patients） received mono-antiplatelet treatment （MAPT） with aspirin 100 mg daily and the other group received dual anfiplatelet treatment （DAPT） with aspirin 100 mg daily plus clopidogrel 75 mg daily. Platelet aggregations in response to arachi- donic acid （PLAA） and adenosine diphosphate （ADP）（PLADP） were measured preoperatively and on days 1 to 6, 8 and 10 after the antiplatelet agents were administered. A PLAA level above 20% was defined as aspirin resistance. Postoperative bleeding and other perioperative variables were also recorded. There were no significant differences between the two groups in baseline characteristics, average number of distal anastomosis, operation time, postoperative bleeding, ventilation time and postoperative hospital stay. However, the incidence of aspirin resistance was significantly lower in the DAPT group than that in the MAPT group on the first and second day after antiplatelet agents were given （62.1% vs, 32.1%, 34.5% vs. 10.7%, respectively, both P 〈 0.05）. There was no significant difference in postoperative complication between the two groups. DAPT with aspirin and clopidogrel can be safely applied to OPCAB patients early after the procedure. Moreover, clopidogrel reduces the incidence of OPCAB-related aspirin resistance.

关键词： aspirin clopidogrel aspirin resistance off-pump coronary artery bypass （OPCAB）

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

针刺治疗阿司匹林抵抗随机对照试验的系统综述(英文)

针刺治疗阿司匹林抵抗随机对照试验的系统综述(英文)

引用

第七届中医/中西医结合循证医学方法研讨会

作者： Guo-qing Zheng Ai-ju Liu Hui-qin Li Ji-huang Li Lin Lu Deng-lei Fu Yan Wang The Center of Neurology and Rehabilitation The Second Affiliated Hospital of Wenzhou Medical University

Ethnopharmacological relevance:aspirin resistance(AR) is prevalent phenomenon and leads to significant clinical consequences,but the current evidence for effective interventional strategy is insufficient.In the past decades,Chinese herbal medicine(CHM) has been used throughout China and elsewhere in the world for the treatment of AR.The objective of this systematic review is thus to assess the efficacy and safety of CHM for AR. Materials and methods:A systematical literature search was conducted in 6 databases until October 2012 to identify randomized controlled trials(RCTs) of CHM for AR. The methodological quality of RCTs was assessed using 12-item criteria from the Cochrane Back Review Group.All data were analyzed using Review Manager 5.0 software. Results:Sixteen RCTs with a total of 1011 subjects were identified.Most of the trials were heterogeneous in the definition of AR,participant characteristics,and CHMtreatment regimen.Tongxinluo capsule and Danshen-based prescriptions were the most frequently used herbal prescriptions,while danshen root,milkvetch root,Leech, and Rosewood were the most frequently used single herbs.Most of herbal preparations (9/12) were Chinese patent medicine,which have a rigorous quality control.Most of the trials had high risk of bias that varied from 2/12 to 6/12,average 3.7. Majority of the RCTs concluded that CHM plus conventional treatment was significantly more effective than single aspirin(100mg/d or 300mg/d),no intervention,and other antiplatelet drug treatment such as dipyridamole, clopidogrel,and cilostazol.Adverse events were only reported in 7/16 trials and were minor. Conclusions:The interests of the public and the medical profession in the use of OHM for AR have grown considerably in the recent years.Despite the apparent reported positive findings,it is premature to determine the efficacy and safety of CHM for the treatment of AR due to poor methodological quality and insufficient safety data. However,CHMs appeared to be well tolerated in all included studies.Therefore,

关键词： Chinese herbal medicine aspirin resistance Systematic review

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：