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asialo gm1-positive liver-resident CD8 T cells that express CD44 and LFA-1 are essential for immune clearance of hepatitis B virus

引用

Cellular & Molecular Immunology 2021年第7期18卷 1772-1782页

作者： Chi-Chang Sung Jau-Hau Horng Shih-Hong Siao I-Tsu Chyuan Hwei-Fang Tsai Pei-Jer Chen Ping-Ning Hsu Graduate Institute of Immunology College of MedicineNational Taiwan UniversityTaipeiChina Graduate Institute of Microbiology College of MedicineNational Taiwan UniversityTaipeiChina Department of Internal Medicine Cathay General HospitalTaipeiChina School of Medicine College of MedicineFu Jen Catholic UniversityNew Taipei CityChina Department of Internal Medicine Taipei Medical University Shuang Ho HospitalTaipeiChina Graduate Institute of Clinical Medicine College of MedicineNational Taiwan UniversityTaipeiChina Department of Internal Medicine National Taiwan University HospitalTaipeiChina

Persistent hepatitis B virus(HBV)infection results in chronic liver diseases that may progress to chronic hepatitis,liver cirrhosis,and subsequent hepatocellular *** studies demonstrated that adaptive immunity,in particular CD8 T cells,is critical in HBV *** studies have revealed a distinct tissue-localized T cell lineage,tissue-resident memory(TRM)cells,that is crucial for protective immunity in peripheral *** this study,we showed that treatment with an anti-asialo gm1(ASgm1)antibody(Ab),which depletes NK cells,led to impairment of HBV clearance in a mouse animal ***,the ability to clear HBV was not significantly impaired in NFIL3 KO mice,which are deficient in NK cells,implying that other non-NK ASgm1-positive immune cells mediate HBV *** isolated intrahepatic ASgm1-positive cells from NFIL3 KO mice and analyzed the immune phenotype of these *** results demonstrated a distinct population of CD44+LFA-1hi CD8 T cells that were the major intrahepatic ASgm1-positive immune cells in NFIL3 KO ***,transcriptome analysis revealed that these ASgm1-positive CD8 T cells had distinct gene profiles and shared a similar core gene signature with TRM *** addition to both transcriptional and phenotypic liver residency characteristics,ASgm1-positive CD8 T cells were able to home to and be retained in the liver after adoptive *** together,our study results indicate that these ASgm1-positive liver-resident CD8 T cells are the major effector immune cells mediating anti-HBV immunity.

关键词： asialo gm-1 liver-resident CD8 T cells HBV clearance

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