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antimicrobial activities of three seaweeds extract against some human viral and bacterial pathogens

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BIOCELL 2022年第1期46卷 247-261页

作者： JELAN MOFEED MOHAMED DEYAB ABDELNASER MOHAMED MAHMOUD MOUSTAFA SALLY NEGM EMAD EL-BILAWY Faculty of Science King Salman International UniversitySinaiEgypt Faculty of Fish Resources Suez UniversitySuezEgypt Faculty of Science Damietta UniversityDamiettaEgypt Department of Biology College of ScienceKing Khalid UniversityAbha9004Saudi Arabia Department of Botany and Microbiology Faculty of ScienceSouth Valley UniversityQenaEgypt Life Sciences Department Faculty of Science and ArtKing Khalid UniversityMahayel Aseer 61421Saudi Arabia Unit of Food Bacteriology Central Laboratory of Food HygieneMinistry of HealthSharkia44516Egypt

Microbial infections cause complicated health influences along with bad economic impacts.In the present investigation,three dominant seaweeds namely,Amphiroa anceps,Corallina officinalis and Sargassum filipendula were collected from different Egyptian sites at the Red Sea and Mediterranean Sea during autumn 2019.Organic extracts of the three algae were screened for their antibacterial activity against three pathogenic bacteria Salmonella typhiimurium,Staphylococcus aureus and Escherichia coli,in addition to in vitro antiviral activity against Rotavirus(RV),and Coxsackie virus B3(CVB3)that cause severe diseases in human.Organic extract of A.anceps,C.officinalis and S.filipendula inhibit E.coli cells by 57.1%,85.7%,and 91.4%,respectively.The highest level of concentration of the C.officinalis extract(100μg/mL)inhibits 100%of Staphylococcus aureus cells followed by S.filipendula and A.anceps extract which inhibit 82.5%and 75%of S.aureus.Similarly,the highest concentration of C.officinalis extract inhibits S.typhiimurium by 80%.The extract of A.anceps exhibited a high antiviral effect against RV infection with TI=22 and virus titers lessened by 2.75 log TCID_(50) followed by extractions of C.officinalis with TI=18.3 and virus titers reduced by 2.5 log TCID_(50).Against CVB3 infection,the extract of A.anceps causes the highest antiviral activity with TI=15 and reduce the viral titers by 2.5 log TCID_(50),followed by extractions of C.officinalis with TI=8.8 and inhibition of virus titers by 1.75 log TCID_(50).Extract of S.filipendula displayed the lowest antiviral effects against RV and CVB3 infection with TI=2.4 and 1.4,respectively.The obtained results clarified that the extract of three marine seaweeds maintains a potent antimicrobial activity,making them a future promising source of new antimicrobial drugs.

关键词： Seaweeds antimicrobial Antibacterial Cytotoxicity Antiviral

antimicrobial Properties and Application of Polysaccharides and Their Derivatives

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Chinese Journal of Polymer Science 2021年第2期39卷 133-146,I0004页

作者： Gui-Xue Xia Yue-Ming Wu Yu-Fang Bi Kang Chen Wei-Wei Zhang Shi-Qi Liu Wen-Jing Zhang Run-Hui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Frontiers Science Center for Materiobiology and Dynamic Chemistry Key Laboratory of Specially Functional Polymeric Materials and Related Technology(ECUST)Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

With the quick emergence of antibiotic resistance and multi-drug resistant microbes,more and more attention has been paid to the development of new antimicrobial agents that have potential to take the challenge.Polysaccharides,as one of the major classes of biopolymers,were explored for their antimicrobial properties and applications,owing to their easy accessibility,biocompatibility and easy modification.Polysaccharides and their derivatives have variable demonstrations and applications as antimicrobial agents and antimicrobial biomaterials.A variety of polysaccharides,such as chitosan,dextran,hyaluronic acid,cellulose,other plant/animal-derived polysaccharides and their derivatives have been explored for antimicrobial applications.We expect that this review can summarize the important progress of this field and inspire new concepts,which will contribute to the development of novel antimicrobial agents in combating antibiotic resistance and drug-resistant antimicrobial infections.

关键词： antimicrobial Drug resistance Polysaccharides Polysaccharide derivatives Chitosan

antimicrobial peptides: new hope in the war against multidrug resistance

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Zoological Research 2019年第6期40卷 488-505页

作者： James Mwangi Xue Hao Ren Lai Zhi-Ye Zhang Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming Yunnan 650204China Sino-African Joint Research Center Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Institutes for Drug Discovery and Development Chinese Academy of SciencesShanghai 201203China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Center for Biosafety Mega-Science Chinese Academy of SciencesWuhan Hubei 430071China

The discovery of antibiotics marked a golden age in the revolution of human medicine. However,decades later, bacterial infections remain a global healthcare threat, and a return to the pre-antibiotic era seems inevitable if stringent measures are not adopted to curb the rapid emergence and spread of multidrug resistance and the indiscriminate use of antibiotics. In hospital settings, multidrug resistant(MDR) pathogens, including carbapenem-resistant Pseudomonas aeruginosa, vancomycin-resistant enterococci(VRE), methicillin-resistant Staphylococcus aureus(MRSA), and extendedspectrum β-lactamases(ESBL) bearing Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae are amongst the most problematic due to the paucity of treatment options,increased hospital stay, and exorbitant medical costs. antimicrobial peptides(AMPs) provide an excellent potential strategy for combating these threats. Compared to empirical antibiotics, they show low tendency to select for resistance, rapid killing action, broad-spectrum activity, and extraordinary clinical efficacy against several MDR strains. Therefore, this review highlights multidrug resistance among nosocomial bacterial pathogens and its implications and reiterates the importance of AMPs as next-generation antibiotics for combating MDR superbugs.

关键词： Multidrug resistance Nosocomial infections antimicrobial peptide Antibiotic alternatives

Inorganic hollow mesoporous spheres-based delivery for antimicrobial agents

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Frontiers of Materials Science 2023年第1期17卷 51-68页

作者： Yunping Qiao Yanyang Han Rengui Guan Shiliang Liu Xinling Bi Shanshan Liu Wei Cui Tao Zhang Tao He Department of Applied Chemistry School of Chemistry and Chemical EngineeringYantai UniversityClearspring RD 3OthLaishanYantai 264005China Weifang Branch Company Shandong Hl-speed Transportation Construction Group Co.Ltd.Qingzhou 262500China Shandong Jinhai Titanium Resources Technology Co. Ltd.Binzhou 256600China

Microorganisms coexist with human beings and have formed a complex relationship with us.However,the abnormal spread of pathogens can cause infectious diseases thus demands antibacterial agents.Currently available antimicrobials,such as silver ions,antimicrobial peptides and antibiotics,have diverse concerns in chemical stability,biocompatibility,or triggering drug resistance.The“encapsulate-and-deliver”strategy can protect antimicrobials against decomposing,so to avoid large dose release induced resistance and achieve the controlled release.Considering loading capacity,engineering feasibility,and economic viability,inorganic hollow mesoporous spheres(iHMSs)represent one kind of promising and suitable candidates for real-life antimicrobial applications.Here we reviewed the recent research progress of iHMSs-based antimicrobial delivery.We summarized the synthesis of iHMSs and the drug loading method of various antimicrobials,and discussed the future applications.To prevent and mitigate the spread of an infective disease,multilateral coordination at the national level is required.Moreover,developing effective and practicable antimicrobials is the key to enhancing our capability to eliminate pathogenic microbes.We believe that our conclusion will be beneficial for researches on the antimicrobial delivery in both lab and mass production phases.

关键词： antimicrobial inorganic hollow mesoporous sphere encapsulate-and-deliver drug delivery

Facial amphiphilicity index correlating chemical structures with antimicrobial efficacy

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Bioactive Materials 2023年第2期20卷 519-527页

作者： Leman Buzoglu Kurnaz Yuanyuan Luo Xiaoming Yang Amjed Alabresm Ryan Leighton Rani Kumar JiHyeon Hwang Alan W.Decho Prakash Nagarkatti Mitzi Nagarkatti Chuanbing Tang Department of Chemistry and Biochemistry University of South CarolinaColumbiaSC29208United States Department of Pathology Microbiology and ImmunologyUniversity of South CarolinaSchool of MedicineColumbiaSC29209United States Department of Environmental Health Sciences University of South CarolinaColumbiaSC29208United States

Facial amphiphilicity is an extraordinary chemical structure feature of a variety of antimicrobial peptides and polymers.Vast efforts have been dedicated to small molecular,macromolecular and dendrimer-like systems to mimic this highly preferred structure or conformation,including local facial amphiphilicity and global amphiphilicity.This work conceptualizes Facial Amphiphilicity Index(FAI)as a numerical value to quantitatively characterize the measure of chemical compositions and structural features in dictating antimicrobial efficacy.FAI is a ratio of numbers of charges to rings,representing both compositions of hydrophilicity and hydrophobicity.Cationic derivatives of multicyclic compounds were evaluated as model systems for testing antimicrobial selectivity against Gram-negative and Gram-positive bacteria.Both monocyclic and bicyclic compounds are non-antimicrobial regardless of FAIs.antimicrobial efficacy was observed with systems having larger cross-sectional areas including tricyclic abietic acid and tetracyclic bile acid.While low and high FAIs respectively lead to higher and lower antimicrobial efficacy,in consideration of cytotoxicity,the sweet spot is typically suited with intermediate FAIs for each specific system.This can be well explained by the synergistic hydrophobic-hydrophobic and electrostatic interactions with bacterial cell membranes and the difference between bacterial and mammalian cell membranes.The adoption of FAI would pave a new avenue toward the design of next-generation antimicrobial macromolecules and peptides.

关键词： antimicrobial Facial amphiphilicity Chemical structure Peptide

Smart dental materials for antimicrobial applications

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Bioactive Materials 2023年第6期24卷 1-19页

作者： Carolina Montoya Lina Roldan Michelle Yu Sara Valliani Christina Ta Maobin Yang Santiago Orrego Department of Oral Health Sciences Kornberg School of DentistryTemple UniversityPhiladelphiaPAUSA Bioengineering Research Group(GIB) Universidad EAFITMedellínColombia Department of Endodontology Kornberg School of DentistryTemple UniversityPhiladelphiaPAUSA Bioengineering Department College of EngineeringTemple UniversityPhiladelphiaPAUSA

Smart biomaterials can sense and react to physiological or external environmental stimuli(e.g.,mechanical,chemical,electrical,or magnetic signals).The last decades have seen exponential growth in the use and development of smart dental biomaterials for antimicrobial applications in dentistry.These biomaterial systems offer improved efficacy and controllable bio-functionalities to prevent infections and extend the longevity of dental devices.This review article presents the current state-of-the-art of design,evaluation,advantages,and limitations of bioactive and stimuli-responsive and autonomous dental materials for antimicrobial applications.First,the importance and classification of smart biomaterials are discussed.Second,the categories of bioresponsive antibacterial dental materials are systematically itemized based on different stimuli,including pH,enzymes,light,magnetic field,and vibrations.For each category,their antimicrobial mechanism,applications,and examples are discussed.Finally,we examined the limitations and obstacles required to develop clinically relevant applications of these appealing technologies.

关键词： antimicrobial Antibacterial Antifungal Smart dental materials Bioresponsive biomaterials Stimuli-responsive Restorative dentistry Biofilm Antibiofilm Bioactive

A polyphenol-modified chitosan hybrid hydrogel with enhanced antimicrobial and antioxidant activities for rapid healing of diabetic wounds

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Nano Research 2023年第1期16卷 905-916页

作者： Zejun Xu Guiting Liu Li Zheng Jun Wu The State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration Life Science InstitutesGuangxi Medical UniversityNanning 530021China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanning 530021China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong 999077China

High oxidative stress injury and bacterial infection are the main challenges that impair wound healing in diabetic patients.Therefore,a hydrogel with enhanced antimicrobial and antioxidant properties was developed for rapid healing of diabetic wounds.In this study,chitosan methacrylate-gallic acid(CSMA-GA)polymer with antioxidant activity,antimicrobial activity,and ultraviolet(UV)-triggered gelling properties was developed as a hydrogel precursor.Meanwhile,amphiphilic Pluronic F127 molecules were used to load hydrophobic chlorhexidine drug molecules to obtain F127/chlorhexidine nanoparticle(NP)with strong antibacterial activity.Subsequently,F127/chlorhexidine NPs were encapsulated in CSMA-GA hydrogel to further enhance its antibacterial activity.The hybrid hydrogel platform(CSMA-GA/F127/chlorhexidine(CMGFC))exhibited high antibacterial efficiency(>99.9%)and strong reactive oxygen species(ROS)scavenging ability(>80.0%),which effectively protected cells from external oxidative stress(upregulated superoxide dismutase(SOD)and glutathione/oxidized glutathione disulfide(GSH/GSSG)levels and downregulated malondialdehyde(MDA)levels).Moreover,in vivo results proved that the CMGFC hydrogel significantly reduced inflammatory responses(downregulated interleukin-6(IL-6)and upregulated interleukin-10(IL-10)levels),promoted angiogenesis(upregulated vascular endothelial growth factor(VEGF)and platelet endothelial cell adhesion molecule-1(CD 31)levels),and wound healing(enhanced collagen deposition and tissue remodelling).Overall,the CMGFC hydrogel with enhanced antimicrobial and antioxidant properties demonstrated significant potential to enhance diabetic wound healing.

关键词： antimicrobial antioxidant diabetic wound hydrogel

Dynamic antimicrobial resistant patterns of Escherichia coli from healthy poultry and swine over 10 years in Chongming Island,Shanghai

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Infectious Diseases of Poverty 2022年第5期11卷 50-62页

作者： Chao Lv Jun Shang Wengang Zhang Bingqing Sun Min Li Chaoyi Guo Nan Zhou Xiaokui Guo Shixin Huang Yongzhang Zhu Department of Animal Health and Food Safety School of Global HealthChinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina One Health Center Shanghai Jiao Tong University-The University of EdinburghShanghai 200025China Shanghai Center for Animal Disease Prevention and Control Shanghai Institute for Veterinary Drugs and Feeds ControlShanghai 201103China

Background:antimicrobial resistance(AMR)is one of the greatest threats to animal and public health.Here,we conducted a dynamic surveillance of Escherichia coli on Chongming Island in Shanghai during 2009-2021 to identify the characteristics and trends of Chongming’s AMR pandemic.Methods:Rectal(cloaca)swabs from four poultry and nine swine farms(Chongming Island,2009-2021)were collected for E.coli strains acquisition.The micro-broth dilution method was used to test antimicrobial susceptibility of E.coli isolates against 10 antimicrobial classes including 15 antimicrobials.Utilizing generalized linear mixed models(GLMMs)and co-occurrence analyses,we further explored the multiple-drug-resistance(MDR)combinations and dynamic patterns of E.coli over 10 years in two food animals.Results:Total of 863 MDR isolates were found among 945 collected E.coli isolates,337 from poultry and 608 from swine.Both isolates exhibited high resistant rates(>70%)to tetracyclines,phenicols,sulfonamides,penicillins,and aminoglycosides(only in swine).The resistant rates of swine isolates to penicillins,aminoglycosides,tetracyclines,phenicols,and polymyxins were significantly higher than those of poultry isolates,whereas resistance to fluoroquinolones was reversed.Resistance to polymyxins decreased similarly in swine(42.4%in 2009 to 0.0%in 2021)and poultry isolates(from 16.5%to 0.0%).However,resistance to other seven antimicrobial classes(excluding carbapenems and penicillins)declined dramatically in swine isolates,particularly fluoroquinolones(from 80.5%to 14.4%),and tendencies of resistance to the seven classes showed markedly divergent patterns in poultry isolates.Using Poisson GLMMs,the AMR carriage since 2016 was significantly lower than that of 2009(odds ratio<1),indicating a decline in the risk of MDR emergence.Furthermore,despite the highly diverse MDR profiles,co-occurrence analysis identified two prominent MDR clusters of penicillins-phenicols-fluoroquinolones in poultry and aminoglycosides-tetracyclines-sulfonamides-phenicols in sw

关键词： antimicrobial resistance Escherichia coli Food animal Longitudinal trend analysis Chongming Island Shanghai

antimicrobial Rubber Nanocapsule-Based Iodophor Promotes Wound Healing

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CCS Chemistry 2020年第2期2卷 245-256页

作者： Ruiting Li Zhen Wang Xiaodong Lian Xiaohua Hu Yapei Wang Department of Chemistry Renmin University of ChinaBeijing 100872China Department of Burns and Plastic Surgery Beijing Jishuitan HospitalBeijing 100035China

Povidone–iodine has been leading the market of clinical disinfectants worldwide since the last century but has turned a blind eye to its cytotoxic effect on the cells of the human tissue.In this study,a commercial povidone–iodine,though considered an excellent antibacterial agent,was found to have a negative influence on mammal cell growth and wound healing in preclinical trials.At the early stage of wound treatment,it even severely deteriorated the wound and enlarged the wound area.However,our newly formulated iodophors,based on rubber nanoparticles,were able to discriminate between human and bacterial cells by inhibiting the cytotoxicity damage caused by iodine to mammalian tissue and vigorously,killed the bacterial cells,thereby,presenting as superior performers of wound care,compared with povidone–iodine.Wetook advantage of a redox combination of an emulsion complex loaded with iodine to solidify a trans-polyisoprene rubber into nanocapsules.Specifically,our fabricated class of rubber nanocapsules proved to be capable of promoting remarkable cell proliferation and wound recovery,thereby,serving as a promising candidate for biocompatible and healing-favored wound disinfection agents in place of povidone–iodine.

关键词： iodine doping antimicrobial rubber nanocapsules iodophor wound healing