Antimicrobial activities of three seaweeds extract against some human viral and bacterial pathogens

作     者：JELAN MOFEED MOHAMED DEYAB ABDELNASER MOHAMED MAHMOUD MOUSTAFA SALLY NEGM EMAD EL-BILAWY 

作者机构：Faculty of ScienceKing Salman International UniversitySinaiEgypt Faculty of Fish ResourcesSuez UniversitySuezEgypt Faculty of ScienceDamietta UniversityDamiettaEgypt Department of BiologyCollege of ScienceKing Khalid UniversityAbha9004Saudi Arabia Department of Botany and MicrobiologyFaculty of ScienceSouth Valley UniversityQenaEgypt Life Sciences DepartmentFaculty of Science and ArtKing Khalid UniversityMahayel Aseer 61421Saudi Arabia Unit of Food BacteriologyCentral Laboratory of Food HygieneMinistry of HealthSharkia44516Egypt 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2022年第46卷第1期

页      面：247-261页

核心收录：

学科分类：0710[理学-生物学] 1006[医学-中西医结合] 10[医学] 100602[医学-中西医结合临床] 

基　　金：Authors would like to thank the Deanship of Scientific Research at King Khalid University Kingdom of Saudi Arabia for Funding(G.R.P./80/42). 

主　　题：Seaweeds Antimicrobial Antibacterial Cytotoxicity Antiviral 

摘      要：Microbial infections cause complicated health influences along with bad economic impacts.In the present investigation,three dominant seaweeds namely,Amphiroa anceps,Corallina officinalis and Sargassum filipendula were collected from different Egyptian sites at the Red Sea and Mediterranean Sea during autumn 2019.Organic extracts of the three algae were screened for their antibacterial activity against three pathogenic bacteria Salmonella typhiimurium,Staphylococcus aureus and Escherichia coli,in addition to in vitro antiviral activity against Rotavirus(RV),and Coxsackie virus B3(CVB3)that cause severe diseases in human.Organic extract of A.anceps,C.officinalis and S.filipendula inhibit E.coli cells by 57.1%,85.7%,and 91.4%,respectively.The highest level of concentration of the C.officinalis extract(100μg/mL)inhibits 100%of Staphylococcus aureus cells followed by S.filipendula and A.anceps extract which inhibit 82.5%and 75%of S.aureus.Similarly,the highest concentration of C.officinalis extract inhibits S.typhiimurium by 80%.The extract of A.anceps exhibited a high antiviral effect against RV infection with TI=22 and virus titers lessened by 2.75 log TCID_(50) followed by extractions of C.officinalis with TI=18.3 and virus titers reduced by 2.5 log TCID_(50).Against CVB3 infection,the extract of A.anceps causes the highest antiviral activity with TI=15 and reduce the viral titers by 2.5 log TCID_(50),followed by extractions of C.officinalis with TI=8.8 and inhibition of virus titers by 1.75 log TCID_(50).Extract of S.filipendula displayed the lowest antiviral effects against RV and CVB3 infection with TI=2.4 and 1.4,respectively.The obtained results clarified that the extract of three marine seaweeds maintains a potent antimicrobial activity,making them a future promising source of new antimicrobial drugs.