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Mature dendritic cell derived from cryopreserved immature dendritic cell shows impaired homing ability and reduced antiviral therapeutic effects

Mature dendritic cell derived from cryopreserved immature de...

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第十一届全国免疫学学术大会

作者： Zhan Linsheng Zhou Qianqian Zhang Yulong Wang Xiaohui Beijing transfusion institute

Objective: Cryopreservation is critical in reducing redundant operations and also in quality control in dendritic cell(DC) therapy. Full maturation and efficient homing of DCs to T cell-region constitute a crucial aspect of DC immunotherapy;however, the in vivo migration and distribution pattern, as well as the anti-viral effect of DC matured from cryopreserved immature DCs(cryoim-m DCs) remain to be ***: In the present study, we compared cryoim-m DCs with DCs matured from fresh immature DCs(fm DCs) in the aspects of phenotypes, in vivo homing capacities as well as the anti-viral therapeutic effects to further clarify the effect of cryopreservation on DC-based cytotherapy. Results: The results show that cryopreservation impair the homing ability of DCs which was associated with the reduced expression of CCR7 and disturbed cytoskeleton arrangement. Moreover, the antigen-specific CD8 T cell response induced by cryoim-m DCs was much weaker than that induced by fm DCs in both the spleen and liver draining lymph nodes, which provided reduced protection from viral invasions. Conclusions: In conclusion, cryopreservation is a good method to keep the viability of immature DCs, however, the in vivo homing capacity and anti-viral therapeutic effect of DC matured from frozen immature DCs were hindered to some extent.

关键词： DCs cryopreservation migration bioluminescence imaging anti-viral effects

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