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anti-aging based on stem cell therapy:A scoping review

World Journal of Experimental Medicine 2024年第3期14卷 57-63页

作者： Nassar El Assaad Alain Chebly Rawad Salame Robert Achkar Nour Bou Atme Khalil Akouch Paul Rafoul Colette Hanna Samer Abou Zeid Marwan Ghosn Charbel Khalil Faculty of Medicine Saint Joseph UniversityBeirut 961Lebanon Centre Jacques Loiselet for Medical Genetics and Genomics(CGGM) Faculty of MedicineSaint Joseph UniversityBeirut 961Lebanon Higher Institute of Public Health Saint Joseph UniversityBeirut 961Lebanon Stem Cell Therapy Lab Reviva Regenerative Medicine CenterBeirut 961Lebanon Poz Pozan University of Medical Sciences Pozan 034Poland Department of Epidemiology and Biostatistics Faculty of Public HealthLebanese UniversityBeirut 961Lebanon School of Medicine Lebanese American UniversityBeirut 961Lebanon Bone Marrow Transplant Unit Burjeel Medical CityAbu Dhabi 999041United Arab Emirates

Stem cells are present in the tissues and organs and remain in a quiescent and undifferentiated state until it is physiologically necessary to produce new descendant *** to their multipotency property,mesenchymal stem cells have attracted considerable attention worldwide due to their immunomodulation and therapeutic function in tissue *** cells secrete components such as paracrine factors,extracellular vesicles,and exosomes which have been shown to have anti-inflammatory,anti-aging,reconstruction and wound healing potentials in many in vitro and in vivo *** pluripotency and immunomodulatory features of stem cells could potentially be an effective tool in cell therapy and tissue *** affects the capacity for self-renewal and differentiation of stem cells,decreasing the potential for regeneration and the loss of optimal functions in organisms over *** progress in the field of cellular therapy and regenerative medicine has facilitated the evolution of particular guidelines and quality control approaches,which eventually lead to clinical *** therapy could potentially be one of the most promising therapies to control aging due to the fact that single stem cell transplantation can regenerate or substitute the injured *** understand the involvement of stem cells not only in tissue maintenance and disease but also in the control of aging it is important to know and identify their properties,functions,and regulation in vivo,which are addressed in this review.

关键词： Mesenchymal stem cell anti-aging Telomerase Regenerative medicine Stem cell therapy

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Application of plant extracts cosmetics in the field of anti-aging

Journal of dermatologic science and cosmetic technology

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Journal of dermatologic science and cosmetic technology 2024年第2期1卷 53-62页

作者： Minghui Xie Zibing Jiang Xingyue Lin Xingchuan Wei School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China

Skin aging is a direct manifestation of body aging,representing a complex and irreversible natural process,which is influenced by genetics,lifestyle and environmental *** the process of skin aging,the skin epidermis gradually become thinner,the inherent repair ability gradually weakens,the collagen and elastin gradually decrease and the skin gradually loses *** skin aging is inevitable,it can be delayed to some extent by using *** extract cosmetics are highly favored by consumers for their safety and efficacy,aligning with consumer preferences for natural,organic,efficient and sustainable skincare *** plant resources in nature possess superior properties like moisturizing,barrier repair,anti-oxidation,sunscreen whitening and anti-inflammatory properties after thousands of years of natural *** properties enable plant components to effectively enhance the anti-aging effects of skincare products through multiple anti-aging pathways,which can be widely used to develop natural anti-aging skin care products.

关键词： Plant resources anti-aging Green Efficacy skin care Cosmetics

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anti-aging effects of chlorpropamide depend on mitochondrial complex-Ⅱ and the production of mitochondrial reactive oxygen species

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Acta Pharmaceutica Sinica B 2022年第2期12卷 665-677页

作者： Zhifan Mao Wenwen Liu Yunyuan Huang Tianyue Sun Keting Bao Jiali Feng Alexey Moskalev Zelan Hu Jian Li State Key Laboratory of Bioreactor Engineering Frontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Key Laboratory of New Drug DesignEast China University of Science and TechnologyShanghai 200237China Laboratory of Geroprotective and Radioprotective Technologies Institute of BiologyKomi Science CentreUral BranchRussian Academy of SciencesSyktyvkar 167982Russia Yunnan Key Laboratory of Screening and Research on anti-pathogenic Plant Resources from West Yunnan College of PharmacyDali UniversityDali 671000China Clinical Medicine Scientific and Technical Innovation Center Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200092China

Sulfonylureas are widely used oral anti-diabetic ***,its long-term usage effects on patients’lifespan remain controversial,with no reports of influence on animal ***,the anti-aging effects of chlorpropamide along with glimepiride,glibenclamide,and tolbutamide were studied with special emphasis on the interaction of chlorpropamide with mitochondrial ATP-sensitive K+(mito K-ATP)channels and mitochondrial complex *** delayed aging in Caenorhabditis elegans,human lung fibroblast MRC-5 cells and reduced doxorubicin-induced senescence in both MRC-5 cells and *** addition,the mitochondrial membrane potential and ATP levels were significantly increased in chlorpropamide-treated worms,which is consistent with the function of its reported targets,mito K-ATP *** levels of mitochondrial reactive oxygen species(mt ROS)were observed in chlorpropamide-treated ***,the lifespan extension by chlorpropamide required complex II and increased mt ROS levels,indicating that chlorpropamide acts on complex II directly or indirectly via mito K-ATP to increase the production of mt ROS as a pro-longevity *** study provides mechanistic insight into the anti-aging effects of sulfonylureas in ***.

关键词： Sulfonylureas Chlorpropamide anti-aging Mitochondrial complexⅡ Mitochondrial reactive oxygen species ATP sensitive potassium channels Senescence Succinate dehydrogenase

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anti-skin aging effects and bioavailability of collagen tripeptide and elastin peptide formulations in young and middle-aged women

Journal of dermatologic science and cosmetic technology

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Journal of dermatologic science and cosmetic technology 2024年第2期1卷 26-37页

作者： Shan Lu Silu Zhang Yun Wang Jiayi Ni Tiantian Zhao Guoxun Xiao Wonderlab Innovation Centre for Healthcare Shenzhen Porshealth Bioengineering CoLtd.Shenzhen 518116China Sericulture&Agri-food Research Institute Guangdong Academy of Agricultural Sciences Key Laboratory of Functional FoodsMinistry of Agriculture and Rural affairsGuangdong Key Laboratory of Agricultural Products ProcessingGuangzhouGuangdong 510610China Department of Dermatology Shanghai Ninth People‘s HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Sprim(China)Consulting Co.Ltd. Shanghai 201201China e Department of Food Science Rutgers UniversityNew BrunswickNJ 08901United States

Background:Collagen peptides(CP),including tripeptides and elastin peptides(EP),are known for their in vitro and in vivo anti-skin aging *** positive results in animal models,the combination effects of CP and EP and the bioavailability of CP in human studies,particularly in young and middle-aged women,remain ***:To evaluate the effects of an orally administered collagen drink combining CP and EP on the skin health of young and middle-aged *** and Methods:A single-center,randomized,double-blind,parallel-controlled trial was conducted,utilizing the WONDERLABR fish collagen tripeptide *** consumed the drink over an 8-week ***:Compared to the placebo group,the collagen drink group showed significant improvements in skin hydration(39.19%increase),transepidermal water loss(33.45%decrease),skin elasticity(25.37%increase),dermal collagen content(21.64%increase),pore size(7.94%decrease),wrinkle length(18.09%decrease),skin smoothness(2.85%improvement),and skin roughness(15.32%decrease).Overall pore volume decreased by 60%,and visual assessments indicated a decrease in skin luminosity by 15.20%and smoothness index by 22.55%.Mass spectrometry demonstrated a significant increase in collagen efficacy components,including blood pH and GPH levels(Panti-skin aging effects of EP and CP on the skin of young and middle-aged women,demonstrating significant improvements in various skin parameters and good bioavailability of collagen peptides.

关键词： Collagen tripeptides Elastin peptides anti-aging Skin protection Peptide absorption

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In vivo anti-aging properties on fat diet-induced high fat Drosophila melanogaster of n-butanol extract from Paecilomyces hepiali

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Food Science and Human Wellness 2023年第4期12卷 1204-1211页

作者： Akang Dan Yushi Chen Yongqi Tian Shaoyun Wang College of Biological Science and Technology Fuzhou UniversityFuzhou 350108China College of Chemical Fuzhou UniversityFuzhou 350108China

The purpose of this study was to explore the potential of the development and application of Paecilomyces hepiali,a fungus with edible and medicinal value,as a foodborne antioxidant and anti-aging *** n-butanol extract(PHE)from rice cultures was selected for anti-aging experiment because of significant free radical scavenging activity in *** vivo,PHE could significantly prolong the mean lifespan,50%survival days,and the maximum lifespan of Drosophila on a high-fat *** is amazing that the mean lifespan increased from 19.1 days to 32.9 days,50%survival days increased from 15.7 days to 34.3 days,and the maximum lifespan extended from 44.7 days to 52.7 days,when the high-fat female Drosophila model was fed with 10μg/mL *** research showed that PHE reduced the accumulation of peroxide products and increased the activity of antioxidant ***,through antioxidant activity tracking,dimerumic acid(compound 1,the IC_(50) value of 3.4μg/mL on DPPH free radicals scavenging activity),4,5-dihydroxy-3-methoxypentanoic acid(compound 2,new compound),and thymidine(compound 3)were isolated from *** is worth mentioning that dimerumic acid,the major antioxidant compound of PHE(content up to 3%),was discovered in *** for the first *** was concluded that PHE showed excellent anti-aging activity at a very low concentration on fat diet-induced high fat Drosophila melanogaster,and dimerumic acid may be its main material *** results indicated that PHE had the potential to be developed as antioxidant and anti-aging agent in the healthcare industry.

关键词： Paecilomyces hepiali anti-aging Drosophila Dimerumic acid

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Determining the in vitro anti-aging Effect of the Characteristic Components from Eucommia ulmoides

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Journal of Renewable Materials 2022年第12期10卷 3131-3145页

作者： Xuesong Wang Zhihong Wang Qiuling Yang Sheng Peng Mijun Peng Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology Guangdong Provincial Engineering Research Center for Ambient Mass SpectrometryInstitute of AnalysisGuangdong Academy of Sciences(China National Analytical CenterGuangzhou)Guangzhou510070China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou510520China National&Local United Engineering Laboratory of Integrative Utilization Technology of Eucommia ulmoides Jishou University Jishou427000China

To evaluate the potential anti-aging ability of Eucommia ulmoides,four characteristic components(chlorogenic acid,geniposidic acid,aucubin,quercetin)were selected to assess their effects on H_(2)O_(2)-induced oxidative damage model of human umbilical vein endothelial cell(HUVEC).Oxidative damage indexes,inflammatory factors,cell cycle,cell apoptosis,cell senescence,and their related proteins were analyzed by methyl thiazolyl tetrazolium(MTT)assay,enzyme-linked immunosorbent assay(ELISA),propidium iodide(PI)staining,annexin V-FITC/PI double staining,SAβ-galactosidase staining,and western blotting(WB).The results showed that H_(2)O_(2)-induced cell growth inhibition rate decreased as supplementation with characteristic components when compared to H_(2)O_(2) ***,the contents of antioxidant indexes(reactive oxygen species,lactate dehydrogenase,molondialdehyde,superoxide dismutase,glutathione),inflammatory factors(nuclear factor kappa-B,intercellular cell adhesion molecule-1,vascular cell adhesion protein 1),and functional factors(NO,Endothelin-1)in characteristic components treated groups improved if comparison with H_(2)O_(2) group,suggesting the characteristic components of *** could alleviate H_(2)O_(2)-induced oxidative ***,cell cycle,cell apoptosis,cell senescence,and their related proteins under characteristic components treatment exhibited a better effect than under H_(2)O_(2) treatment,implying the characteristic components could participate in anti-aging via multiple *** results manifested that the characteristic components of *** posses the capacity of anti-aging,which provided a basis for investigating the anti-aging ability of *** itself.

关键词： anti-aging Eucommia ulmoides characteristic components oxidative damage cell senescence

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Behavior and metabolomics study of the anti-aging effects of Scutellaria baicalensis Georgi extract on D-galactose-induced rats

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中国药理学与毒理学杂志 2015年第S1期29卷 75-76页

作者： Yu-shiZHOU Yan-fenCHANG Guan-huaDU Xue-meiQIN Modern Research Center for Traditional Chinese Medicine of Shanxi University Taiyuan 030006 China College of Chemistry and Chemical Engineering of Shanxi University Taiyuan 030006 China Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China

OBJECTIVE Behavior research and urinary metabolomics method were applied to evaluate the anti-aging effects of Scutellaria baicalensis Georgi extract(SBG)in D-galactose-induced *** Fifty rats were randomly divided into five groups(n=10in each group).Group 1served as vehicle control with injection of saline(vehicle control group),and the other groups of rats received daily subcutaneously injected with D-galactose(aged model group)at dose of 100mg·kg-1 for ten weeks,*** the same time,rats in groups 3-5were intragastrically administered SBG 〔extracted twice with 60%(V/V)ethanol〕at doses of 50,100 and 200mg·kg-1 for ten weeks,and the rats of groups 1 and 2 were administrated an equal volume of the *** the tenth week,the learning and memory abilities were examined by Morris water *** urine was collected using metabolic cages and analyzed by high-resolution 1HNMR spectroscopy combined with multivariate statistical *** component analysis(PCA)was utilized to classify and reveal the differences between the model group and control ***,the concentration of these differences was analyzed with t-test to determine whether SBG was possible to influence the metabolic pattern induced by *** Compared with the vehicle control group,the D-galactose-treated aged model group markedly spent longer time(P<0.05)in finding the platform on days 3-5 in the spatial learning acquisition training of Morris water maze ***,the escape latency was significantly reduced(P<0.05)by long-term administration of SBG(50,100 and 200mg·kg-1)compared with the D-galactose-treated aged model group on days *** the probe test,the D-galactose-treated aged model group made fewer(P<0.05)platform crossings and distance travelled in target quadrant(P<0.05)than the vehicle control group,and the SBG at doses of 50,100 and 200mg·kg-1 treatments groups could significantly increase(P<0.05)the number of times of crossing over the platform site

关键词： Scutellaria baicalensis Georgi anti-aging metabolo

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Current Perspective in the Discovery of anti-aging Agents from Natural Products

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Natural Products and Bioprospecting 2017年第5期7卷 335-404页

作者： Ai-Jun Ding Shan-Qing Zheng Xiao-Bing Huang Ti-Kun Xing Gui-Sheng Wu Hua-Ying Sun Shu-Hua Qi Huai-Rong Luo State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina University of Chinese Academy of Sciences Beijing 100039China Key Laboratory for aging and Regenerative Medicine Department of PharmacologySchool of PharmacySouthwest Medical UniversityLuzhou 646000SichuanChina Guangdong Key Laboratory of Marine Material Medical South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301GuangdongChina Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of Sciences134 Lanhei RoadKunming 650201YunnanChina

aging is a process characterized by accumulating degenerative damages,resulting in the death of an organism *** main goal of aging research is to develop therapies that delay age-related diseases in *** signaling pathways in aging of Caenorhabditis elegans(***),fruit flies and mice are evolutionarily conserved,compounds extending lifespan of them by intervening pathways of aging may be useful in treating age-related diseases in *** products have special resource advantage and with few side ***,many compounds or extracts from natural products slowing aging and extending lifespan have been *** we summarized these compounds or extracts and their mechanisms in increasing longevity of *** or other species,and the prospect in developing antiaging medicine from natural products.

关键词： aging Natural products anti-aging Drug screening

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Polydeoxyribonucleotide: A promising skin anti-aging agent

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Chinese Journal of Plastic and Reconstructive Surgery 2022年第4期4卷 187-193页

作者： Aawrish Khan Guobao Wang Feng Zhou Lunli Gong Jun Zhang Lili Qi Haiyan Cui Department of Plastic and Cosmetic Surgery Tongji Hospital of Tongji UniversityShanghai200065China

Polydeoxyribonucleotide(PDRN) consists of DNA fragments with molecular weights ranging from 50 to 1 500 kDa,which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many preclinical and clinical studies have demonstrated the properties of PDRN. These include anti-inflammatory, anti-apoptotic, antiosteoporotic, anti-melanogenetic, anti-allodynic, anti-osteonecrotic, bone regenerative, tissue damage preventive,anti-ulcerative, and wound healing properties, which are mediated by the activation of the adenosine A2Areceptor and salvage pathways. Moreover, PDRN promotes angiogenesis, cellular activity, collagen synthesis, soft tissue regeneration, and skin priming and revitalization and can be used to treat hyperpigmentation. Therefore, this review assessed the potential use of PDRN as an anti-aging agent for the skin.

关键词： Polydeoxyribonucleotide anti-aging Skincare Marine organisms DNA

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Exploring the anti-aging effects of chlorogenic acid and the underlying mechanisms based on a Caenorhabditis elegans model

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Journal of Traditional Chinese Medical Sciences 2023年第2期10卷 208-217页

作者： Yuqian Yang Xu Chen Danyang Ye Chuanyu Wei Xinxin Pang Chuchu Kong Yongsheng Fang Hongliu Yang Yuanyuan Zhang Yonggang Liu School of Chinese Materia Madica Beijing University of Chinese MedicineBeijing102488China Krannert Institute of Cardiology Indiana UniversityBurmingtonIndiana46517USA

Objective:To explore the anti-aging effects of chlorogenic acid(CGA)and the underlying mechanisms based on a Caenorhabditis elegans(***)***:The anti-agingactivityofCGAwasstudied basedon thebodylength,exercisebehavior,lipofuscin content,antioxidative stress ability,swallowing frequency,body-bending frequency,and head-swinging ability of *** DAF-16 nuclear translocation and SOD-3-GFP fluorescence experiments,the effects of CGA on ROS levels,antioxidant enzyme activities,MDA content,mutant-strain lifespan,and anti-aging molecular signaling pathways were explored,as well as the underlying ***:CGA improved multiple indices of the nematode:body length was increased(all Panti-aging role in *** underlying mechanisms include activation of the insulin/IGF-1 signaling pathway and enhancement of DAF-16 *** study lays a foundation for further research into the anti-aging effects of CGA.

关键词： Chlorogenic acid Caenorhabditis elegans antioxidant activity anti-aging DAF-16

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