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Evaluation of high-concentration sevoflurane for induction and nasotracheal intubation without muscle relaxant for infants with different pulmonary blood flow undergoing surgery for congenital heart diseases

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Chinese Medical Journal 2011年第24期124卷 4144-4148页

作者： WANG Kai-yuan WANG Hong-wu XIN Lian-feng WANG Yong-wang XUE Yu-liang Department of Anesthesiology TEDA International CardiovascularHospital Tianjin 300457 China

Background inhalational anesthesia with sevoflurane for endotracheal intubation without muscle relaxant is now used widely for pediatric patients. This study assessed the efficacy and safety of induction with high concentration sevoflurane and of nasotracheal intubation without muscle relaxant in infants with increased or decreased pulmonary blood flow （PBF） and undergoing surgery for congenital heart diseases. Methods Fifty-five infants aged 2-12 months, weighing 4.7-10.0 kg, and scheduled for congenital cardiac surgery were enrolled. Subjects were divided into those with increased （IPBF group, n--29） and decreased （DPBF group, n=26） pulmonary blood flow. All infants received inhalational induction with 8% sevoflurane in 100.0% oxygen at a gas flow rate of 6 L/min. Nasotracheal intubation was performed 4 minutes after induction. Sevoflurane vaporization was decreased to 4.0% for placement of a peripheral intravenous line and invasive hemodynamic monitors. Five minutes later, sedatives and muscle relaxant were administered and the vaporizer was adjusted to 2% for maintenance of anesthesia. Bispectral index （BIS） scores, circulatory parameters, satisfactory and successful intubation ratios, adverse reactions, and complications of intubation were recorded. Results Times to loss of lash and pain reflexes were longer for the DPBF group （P 〈0.01）. Satisfactory intubation ratios were 93.1% and 61.5% for the I PBF and DPBF groups, respectively （P=0.008）. Successful intubation ratios were 96.6% and 76.9% for the IPBF and DPBF groups, respectively （P=0.044）. Following sevoflurane inhalation, blood pressures decreased significantly in the IPBF group but remained stable in the DPBF group. BIS scores declined to similar stable values, and a ＂nadir BIS＂ was recorded for both groups. No obvious adverse reactions or complications of intubation were noted perioperatively. Conclusions Induction with high concentration sevoflurane, although faster for infants with IPBF, is safe

关键词： anesthetics, inhalation infant intubation, intratracheal heart defects, congenital

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Combined effect of hypothermia and crystalloid hemodilution on the solubility of volatile anesthetics in human blood

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Chinese Medical Journal 2002年第7期115卷 1014-1019,147页

作者：周建新刘永勤刘进首都医科大学附属北京天坛医院外科ICU 北京100050 四川大学华西医院麻醉科成都610041

OBJECTIVE: To determine the combined effect of hypothermia and crystalloid hemodilution on blood solubility of volatile anesthetics. METHODS: Two hundred and thirty ml blood samples obtained from each of twelve healthy male volunteers were adjusted to a hematocrit of 40% and then diluted with normal saline to hematocrits of 36%, 32%, 28%, 24%, and 20%. Blood/gas partition coefficients of desflurane, sevoflurane, isoflurane, enflurane and halothane were measured at 37 degrees C,33 degrees C, 29 degrees C, 25 degrees C, 21 degrees C and 17 degrees C using a two-stage headspace double equilibration method. RESULTS: As the temperature decreased, the logarithm of the blood/gas partition coefficient increased linearly (P

关键词： Cold Hemodilution Adult anesthetics, inhalation Hematocrit Humans Hypothermia, Induced Male Plasma Substitutes Solubility

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