Combined effect of hypothermia and crystalloid hemodilution on the solubility of volatile anesthetics in human blood

作     者：周建新 刘永勤 刘进 Zhou Jianxin;LIU Yongqin;LIU Jin

作者机构：首都医科大学附属北京天坛医院外科ICU北京100050 四川大学华西医院麻醉科成都610041 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2002年第115卷第7期

页      面：1014-1019,147页

核心收录：

学科分类：1002[医学-临床医学] 100217[医学-麻醉学] 10[医学] 

主　　题：Cold Hemodilution Adult Anesthetics, Inhalation Hematocrit Humans Hypothermia, Induced Male Plasma Substitutes Solubility 

摘      要：OBJECTIVE: To determine the combined effect of hypothermia and crystalloid hemodilution on blood solubility of volatile anesthetics. METHODS: Two hundred and thirty ml blood samples obtained from each of twelve healthy male volunteers were adjusted to a hematocrit of 40% and then diluted with normal saline to hematocrits of 36%, 32%, 28%, 24%, and 20%. Blood/gas partition coefficients of desflurane, sevoflurane, isoflurane, enflurane and halothane were measured at 37 degrees C,33 degrees C, 29 degrees C, 25 degrees C, 21 degrees C and 17 degrees C using a two-stage headspace double equilibration method. RESULTS: As the temperature decreased, the logarithm of the blood/gas partition coefficient increased linearly (P