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Chinese Journal of Chemistry 2017年第4期35卷 429-434页

作者： Feng Lin Rongran Liang Qiaoyan Qi Tianguang Zhan Zhanting Li Xin Zhao Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China Department of Chemistry Fudan University Shanghai 200433 China

Amphiphilic molecules have long been regarded as an important class of supramolecular building blocks for the fabrication of nanomaterials. While most previous researches have mainly focused on amphiphlies with flexible structures, in this work, four novel amphiphiles possessing wholly-rigid skeletons have been designed and synthe- sized. These molecules were built by using 4,4＇-bipyridin-l-ium or viologen as hydrophilic moieties and phenyl or biphenyl as hydrophobic segments, bridged by a pyridazine unit. Their self-assembly behavior has been investigated by scanning electron microscopy （SEM）, atomic force microscopy （AFM） and transmission electron microscopy （TEM）, which revealed they could self-assemble into well-ordered nanoarchitectures with various morphologies such as vesicles, micro/nanorods and nanotubes in water or methanol, depending on their hydrophilic/hydrophobic fraction ratios.

关键词： amphiphiles self-assembly hydrophobic-lipophilic interaction aromatic stacking rigid conformation

Pillar[5]arene-modified peptide-guanidiniocarbonylpyrrol amphiphiles with gene transfection properties

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Chinese Chemical Letters 2023年第5期34卷 246-249页

作者： Kaiya Wang Minzan Zuo Tao Zhang Huilan Yue Xiao-Yu Hu College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Qinghai Provincial Key Laboratory of Tibetan Medicine Research and Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810008China

Pillar[5]arene-modified amphiphilic peptides with varying numbers of guanidiniocarbonylpyrrol(GCP)moieties have been successfully synthesized,which can self-assemble to multivalent cationic superstructures in aqueous *** assembled peptides can condense DNA into various compact multimolecular aggregates to achieve successful intracellular DNA delivery and demonstrate great potential for gene *** efficiencies of the self-assembled superstructures have been evaluated in vitro with He La and HEK 293T *** demonstrate that GCP moiety could enhance the cell transfection ability,owing to its excellent binding towards *** was also found that subtle structure difference in peptides 2 and 3 could result in distinct transfection efficacy,which makes it possible to gain an in-depth understanding of their structure-activity *** work presents a good example of rational structural design in achieving effective gene transfection vectors.

关键词： Pillararene Guanidinocarbonylpyrrole Gene transfection amphiphiles Structure-activity relationship

Recent development of pillar[n]arene-based amphiphiles

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Chinese Chemical Letters 2021年第4期32卷 1267-1279页

作者： Yan Cai Zhecheng Zhang Yue Ding Lanping Hu Jin Wang Tingting Chen Yong Yao School of Chemistry and Chemical Engineering Nantong UniversityNantong 226019China

Pillar[n]arene-based amphiphiles,mainly including amphiphilic pillar[n]arenes and supra-amphiphilic pillar[n]arenes,have obtained considerable interests in recent years due to their fascinating chemical structures,various self-assembly behaviors,and widely *** to the pillar-like frameworks and the rich host-guest recognitions of the cavities,these amphiphiles can be easily controlled to form dimensional and morphologic assemblies for multiple *** with traditional linear covalent amphiphiles,the introduction of host-guest recognitions facilitated the preparation and controllability of these supramolecular amphiphilic ***,the host-guest recognitions endow the assemblies from pillar[n]arene-based amphiphiles with stimuli-responsive *** this mini-review,we summarized the chemical structures,self-assembly features,and the applications of pillar[n]arene-based ***,several research topics of pillar[n]arenebased amphiphiles can be further developed in the future,such as larger cavity amphiphilic pillar[n]arenes,co-assembly with 2 D materials and utilization of the host-guest interactions.

关键词： Pillararene Supramolecular assemblies amphiphiles Reversible conversion Controlled release

Recent Progress in Fluorescent Vesicles with Aggregation-induced Emission

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Chinese Journal of Polymer Science 2019年第4期37卷 352-371,I0006页

作者： Hui Chen Min-Hui Li Chimie ParisTech PSL University ParisCNRSInstitut de Recherche de Chimie Paris Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology

Fluorescent vesicles have recently attracted increasing attention because of their potential applications in bioimaging,diagnostics, and theranostics, for example, in vivo study of the delivery and the distribution of active substances. However, fluorescent vesicles containing conventional organic dyes often suffer from the problem of aggregation-caused quenching(ACQ) of *** vesicles working with aggregation-induced emission(AIE) offer an extraordinary tool to tackle the ACQ issue, showing advantages such as high emission efficiency, superior photophysical stability, low background interference, and high sensitivity. AIE fluorescent vesicles represent a new type of fluorescent and functional nanomaterials. In this review, we summarize the recent advances in the development of AIE fluorescent vesicles. The review is organized according to the chemical structures and architectures of the amphiphilic molecules that constitute the AIE vesicles, i.e., small-molecule amphiphiles, amphiphilic polymers, and amphiphilic supramolecules and supramacromolecules. The studies on the applications of these AIE vesicles as stimuli-responsive vesicles,fluorescence-guided drug release carriers, cell imaging tools, and fluorescent materials based on fluorescence resonance energy transfer(FRET) are also discussed.

关键词： Vesicles Polymersomes Aggregation-induced emission Small-molecule amphiphiles Amphiphilic polymers Amphiphilic supramolecules Amphiphilic supramacromolecules

Pod-Like Supramicelles with Multicompartment Hydrophobic Cores Prepared by Self-Assembly of Modified Chitosan

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Nano-Micro Letters 2016年第2期8卷 151-156页

作者： Yiming Wang Jie Wang Tongshuai Wang Yisheng Xu Lei Shi Yongtao Wu Li Li Xuhong Guo State Key Laboratory of Chemical Engineering East China University of Science and Technology Firmenich Aromatics (China) Co. Ltd.

In this paper, pod-like supramicelles with multicompartment hydrophobic cores were prepared by selfassembly of amphiphilic N-phthaloylchitosan-g-poly(N-vinylcaprolactam)(PHCS-g-PNVCL) in aqueous medium. The employed biocompatible amphiphilic polymer was synthesized by grafting the carboxyl terminated poly(N-vinylcaprolactam)(PNVCL-COOH) chains onto N-phthaloylchitosan(PHCS) backbone.~1H NMR and FTIR results confirmed the molecular structure of the copolymers. The morphology of the supramicelles assembled by PHCS-g-PNVCL was revealed by means of TEM and polarized light microscope. In solution, the supramicelles were very stable as monitored by DLS and zeta potential measurements. Temperature and p H presented significant influences on the size and size distribution of the supramicelles. These supramicelles with multicompartment hydrophobic cores should be ideal biomimetic systems with promising applications in drug delivery.

关键词： Chitosan Graft copolymers amphiphiles Self-assembly Multicompartment supramicelles

Synthesis of Novel Glycidol Copolymers with Pendant Alkene and Hydroxyl Groups

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Chinese Journal of Chemistry 2013年第10期31卷 1315-1320页

作者： Siwei Liu Feng Zhang Yi Zhang Jiarui Xu PCFM Lab School of Chemistry and Chemical Engineering Sun Yat-sen University Guangzhou Guangdong 510275 China

A series of linear poly glycidol copolymers, tethering with both alkene and hydroxyl groups, were prepared by a combination of anionic ring-opening polymerization （ROP） using specific reactions of ethoxy ethyl glycidyl ether （EEGE） and allyl glycidyl ether （AGE） firstly, and subsequently removal of the protection group of glycidol in EEGE to achieve the linear copolymer pendant with both hydroxyl groups and double bonds. The EEGE/AGE monomer reactivity ratio is measured to be 3.30/1.13. The chemical compositions of the as-synthesized polymers were characterized by tH NMR and GPC, and the glass transition temperatures （Tg） of as-synthesized polymers were determined by DSC. The final copolymers have abundant double bonds and hydroxyl as side groups. Furthermore, the ratio of the double bonds to hydroxyl groups can be controlled by the ratio of the starting materials in a wide range.

关键词： amphiphiles anions ring-opening polymerization glycidol copolymers biomaterials

Constitutionally adaptive crown ether-based macrocyclic bolaamphiphile with redox-responsive switching of lower critical solution temperature behaviors

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Chinese Chemical Letters 2021年第12期32卷 4024-4028页

作者： Qiangqiang Xu Zhiliyu Cui Jizhen Yao Bo Li Ping Lv Xin Shen Zhuo Yu Yan Ge Zhenhui Qi Sino-German Joint Research Lab for Space Biomaterials and Translational Technology Synergetic Innovation Center of Biological Optoelectronics and Healthcare Engineering(BOHE)Xi'an 710072China

Constitutionally adaptive chemistry of selenium-containing crown ethers(CEs) offers a new platform for controlling/switching the hydration of bolaamphiphile skeletons in water in an effective and simple manner by the virtue of covalent bonding. The adaptive behaviour of the macrocyclic bolaamphiphiles(transformations between C7SeBola and C7SeOBola) in response to redox environment was found to be a decisive factor.

关键词： Macrocycle Crown ether Bola amphiphiles Selenium

An Overview of Self-Assembly and Morphological Regulation of Amphiphilic DNA Organic Hybrids

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Chinese Journal of Chemistry 2015年第5期33卷 511-516页

作者： Fen Wu Yiyang Zhang Zhongqiang Yang Key Laboratory of Organic Optoelectronics&Molecular Engineering of the Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China

In this review,we summarized the assembly behavior of DNA organic hybrids and listed reported strategies of tuning the morphology of *** self-assembly and morphological regulation of DNA organic hybrids provide an effective way to construct functional nanostructures with potential applications in nanomaterials,drug delivery and tissue *** future directions are discussed.

关键词： DNA amphiphiles self-assembly morphology regulation

Study on Thermosensitive Micellization of Dextran-g-PNIPAAm in Aqueous Solutions

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Chinese Chemical Letters 2006年第6期17卷 837-840页

作者： Dan ZHAO Li Qun WANG Ke Hua TU Song Wei TAN Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027

The thermosensitive micellization of dextran-g-PNIPAAm in aqueous solutions has been investigated by fluorescence spectroscopy, dynamic light scattering and transmission electron microscope. The formed polymeric micelles showed different diameters of about 20 nm or 100 nm, when the solution temperature was below or above the phase transition temperature.

关键词： amphiphiles micelles poly(N-isopropylacrylamide) thermosensitive copolymers.

CO_(2) and photo-controlled reversible conversion of supramolecular assemblies based on water soluble pillar[5]arene and coumarin-containing guest

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Chinese Chemical Letters 2021年第1期32卷 349-352页

作者： Yufeng Cao Yanmei Chen Zhecheng Zhang Jin Wang Xiaolei Yuan Qin Zhao Yue Ding Yong Yao School of Chemistry and Chemical Engineering Nantong UniversityNantong 226019China

In this communication,a new supramolecualr amphiphile was successfully constructed based on water soluble pillar[5]arene and a unique guest which contain a CO_(2) responsive tertiary amine unit and a UV responsive coumarin *** guest molecule 1 dispersed in water,it self-assembled into sheet-like *** bubbling CO_(2),1 transformed into 1 H due to the tertiary amine unit was protonated,accompany the nano-sheets transformed into *** irradiation of 1 H with 365 nm light for 3 h,the coumarin group reacted with each other to form bola-type amphiphie 2 *** this case,vesicles collapsed and re-assembled into ***,when addition of WPS into the solution of 1 H,the vesicles transformed into micelles,this is due to the formation of supramolecular amphiphile WP5&1 *** irradiation of WP5&1 H with 365 nm light for 3 h,nano-ribbons observed instead of micelles in the ***,nanotubes from 2 H could also transform into nano-ribbons after adding *** selfassembly process and the resultant assemblies were characterized by TEM,SEM,DLS,SAXS and NMR *** to both CO_(2) and light are "green" for living organisms,we anticipated our system can offer the possibilities in "on demand" drug absorption and release.

关键词： Pillararene Supramolecular assemblies amphiphiles Reversible conversion Coumarin