Pillar[5]arene-modified peptide-guanidiniocarbonylpyrrol amphiphiles with gene transfection properties

作     者：Kaiya Wang Minzan Zuo Tao Zhang Huilan Yue Xiao-Yu Hu Kaiya Wang;Minzan Zuo;Tao Zhang;Huilan Yue;Xiao-Yu Hu

作者机构：College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 211106China Qinghai Provincial Key Laboratory of Tibetan Medicine Research and Key Laboratory of Tibetan Medicine ResearchNorthwest Institute of Plateau BiologyChinese Academy of SciencesXining 810008China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第5期

页      面：246-249页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0703[理学-化学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：supported by the Natural Science Foundation of Jiangsu Province(Nos.BK20200432,BK20211179) National Natural Science Foundation of China(Nos.22271154,M-0411) the Fundamental Research Funds for the Central Universities(Nos.NG2022003,NS2021040) 

主　　题：Pillararene Guanidinocarbonylpyrrole Gene transfection Amphiphiles Structure-activity relationship 

摘      要：Pillar[5]arene-modified amphiphilic peptides with varying numbers of guanidiniocarbonylpyrrol(GCP)moieties have been successfully synthesized,which can self-assemble to multivalent cationic superstructures in aqueous *** assembled peptides can condense DNA into various compact multimolecular aggregates to achieve successful intracellular DNA delivery and demonstrate great potential for gene *** efficiencies of the self-assembled superstructures have been evaluated in vitro with He La and HEK 293T *** demonstrate that GCP moiety could enhance the cell transfection ability,owing to its excellent binding towards *** was also found that subtle structure difference in peptides 2 and 3 could result in distinct transfection efficacy,which makes it possible to gain an in-depth understanding of their structure-activity *** work presents a good example of rational structural design in achieving effective gene transfection vectors.