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Chinese Population Reference Curves for Ultrasound-Measured amniotic fluid Deepest Vertical Pocket in Dichorionic Twin Pregnancies,and Their Associations With Pregnancy Outcomes

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Maternal-Fetal Medicine 2024年第1期6卷 29-36页

作者： Zhengxin Lyu Tianchen Wu Shan Lu Pengbo Yuan Yangyu Zhao Yuan Wei Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China

Objective:To establish the Chinese population's amniotic fluid deepest vertical pocket(DVP)reference curves for dichorionic twin pregnancies and to investigate DVP links with adverse perinatal ***:This retrospective cohort study,conducted at Peking University Third Hospital from August 2011 to December 2020,used data from 375 women aged 20 to 45 years who had dichorionic twin pregnancies that were confirmed through first-trimester *** exclusions,reference curves were developed using 318 women with 3,299 DVP scans,and the data analyzed included maternal demographics,pregnancy outcomes,ultrasound measurements,and neonatal *** were assessed via ultrasound at regular intervals and grouped by gestational age(GA)for *** mixed models were used to create amniotic fluid reference *** between abnormalities and adverse perinatal outcomes were examined using Chi-squared or Fisher's exact *** regression provided both crude and adjusted odds ratios,adjusting for pre-pregnancy weight,age,ethnicity,parity,and conception *** was set at P<0.05 with 95%confidence intervals(CI),and the analyses were conducted using SPSS ver.26.0(IBM Corp.,Armonk,NY)and SAS ver.9.4(SAS Institute Inc.,Cary,NC,USA)***:DVP increased from the first trimester to a maximum at 26 weeks(95%confidence interval(CI),2.7–8.3 cm for twin 1 and 2.8–7.9 cm for twin 2)and then decreased gradually toward *** between twins 1 and 2 were significant after 26 weeks(95%CI for twin 1:5.3,5.5;95%CI for twin 2:4.4,4.5;P<0.010).Polyhydramnios of twin 1 increased the risk of large for *** of twin 1 increased the risk of small for *** of twin 2 increased the risk of small for GA,premature birth,and neonatal *** of twin 2 increased the risk of preeclampsia,hypertensive disorder complicating pregnancy,and premature rupture of ***:Reference curves

关键词： amniotic fluid amniotic fluid deepest vertical pocket Reference curve Dichorionic twin Pregnancy outcome Ultrasound examination

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amniotic fluid stem cell-based models to study the effects of gene mutations and toxicants on male germ cell formation

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Asian Journal of Andrology 2012年第2期14卷 247-250页

作者： Claudia Gundacker Helmut Dolznig Mario Mikula Margit Rosner Oliver Brandau Markus Hengstschlager Medical Genetics Medical University of Vienna Vienna 1090 Austria

Male infertility is a major public health issue predominantly caused by defects in germ cell development. In the past, studies on the genetic regulation of spermatogenesis as well as on negative environmental impacts have been hampered by the fact that human germ cell development is intractable to direct analysis in vivo. Compared with model organisms including mice, there are fundamental differences in the molecular processes of human germ cell development. Therefore, an in vitro model mimicking human sperm formation would be an extremely valuable research tool. In the recent past, both human embryonic stem （ES） cells and induced pluripotent stem （iPS） cells have been reported to harbour the potential to differentiate into primordial germ cells and gametes. We here discuss the possibility to use human amniotic fluid stem （AFS） ceils as a biological model. Since their discovery in 2003, AFS cells have been characterized to differentiate into cells of all three germ layers, to be genomically stable, to have a high proliferative potential and to be non-tumourigenic. In addition, AFS cells are not subject of ethical concerns. In contrast to iPS cells, AFSs cells do not need ectopic induction of pluripotency, which is often associated with only imperfectly cleared epigenetic memory of the source cells. Since AFS cells can be derived from amniocentesis with disease-causing mutations and can be transfected with high efficiency, they could be used in probing gene functions for spermatogenesis and in screening for male reproductive toxicity.

关键词： amniotic fluid human genetics infertility primordial germ cells reproduction spermatogenesis stem cells toxicity

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Study of concentration of amniotic fluid Alpha-fetal protein in thalassemia fetus

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 192-194页

作者： Yi Ling Yan-Hong Yu Song Jin Chun-Xia Hu Wei Peng Hong-Yu Zhang Huo Fu Ning Zhang Yan-Xin Wei Ze-Jun Chen Department of Obstetrics and Gynecology Souther HospitalAffiliated Hospital of Southern Medical University Department of Obstetrics Prenatal Diagnose CenterAffiliated Hospital of Hainan Medical University

Objective:To test the hypothesis that concentration of amniotic fluid alpha-fetal protein(AFAFP) is increased in thalassemia ***:A total of 135 cases of amniocentesis admitted from July 2013 to December 2014 were included in this *** them 98 cases of normal fetuses were assigned into control group and 37 cases of thalassemia fetus were included as thalassemia fetus ***-fetoprotein levels detected by enzyme linked immunosorbent assay and the alpha-fetoprotein concentration were compared between the two *** is no significant difference in gestrational age between the two ***:*** concentration in thalassemia fetus group was significantly higher than that of normal control group [(1541.65±734.78) μg/mL vs.(2728.84± 1539.97) μg/mL ],and amniotic fluid AFP concentration was related to fetal *** concentration in pureα-thalassemia fetus was higher than that of β thalassemia fetus or mixed αand was not ***:Concentration of a β thalassemia fetus,but the difference mniotic fluid alpha-fetal protein is increased in thalassemia *** concentration inα-thalassemia fetus was higher than that of β thalassemia or mixed αand lore β thalassemia fetus but difference was not *** studies are needed to exp the possible correlation between Down syndrome and biochemical markers of Thalassemia.

关键词： Alpha-fetoprotein amniotic fluid Thalassemia Fetus

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Human amniotic fluid stem cell therapy can help regain bladder function in type 2 diabetic rats

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World Journal of Stem Cells 2022年第5期14卷 330-346页

作者： Ching-Chung Liang Steven W Shaw Yung-Hsin Huang Tsong-Hai Lee Female Urology Section Department of Obstetrics and GynecologyLinkou Chang Gung Memorial HospitalCollege of MedicineChang Gung UniversityTaoyuan 333Taiwan Division of Obstetrics Department of Obstetrics and GynecologyTaipei Chang Gung Memorial HospitalTaipei 105Taiwan Prenatal Cell and Gene Therapy Group Institute for Women’s HealthUniversity College LondonLondon WC1E 6BTUnited Kingdom Stroke Center and Department of Neurology Linkou Chang Gung Memorial HospitalCollege of MedicineChang Gung UniversityTaoyuan 333Taiwan

BACKGROUND Diabetes mellitus(DM)is a serious and growing global health *** is estimated that 80%of diabetic patients have micturition problems such as poor emptying,urinary incontinence,urgency,and urgency *** with diabetic bladder dysfunction are often resistant to currently available *** is necessary to develop new and effective treatment *** To examine the therapeutic effect of human amniotic fluid stem cells(hAFSCs)therapy on bladder dysfunction in a type 2 diabetic rat *** Sixty female Sprague-Dawley rats were divided into five groups:Group 1,normal-diet control(control);group 2,high-fat diet(HFD);group 3,HFD plus streptozotocin-induced DM(DM);group 4,DM plus insulin treatment(DM+insulin);group 5,DM plus hAFSCs injection via tail vein(DM+hAFSCs).Conscious cystometric studies were done at 4 and 12 wk after insulin or hAFSCs treatment to measure peak voiding pressure,voided volume,intercontraction interval,bladder capacity,and residual *** and/or mRNA expression of muscarinic receptors,nerve growth factor(NGF),and sensory nerve markers in the bladder and insulin,MafA,and pancreatic-duodenal homeobox-1(PDX-1)in pancreatic beta cells were *** Compared with DM rats,insulin but not hAFSCs treatment could reduce the bladder weight and improve the voided volume,intercontraction interval,bladder capacity,and residual volume(P0.05).The immunoreactivities and mRNA expression of M2-and M3-muscarinic receptors(M2 and M3)were increased mainly at 4 wk(P<0.05),while the number of beta cells in islets and the immunoreactivities and/or mRNA of NGF,calcitonin gene-related peptide(CGRP),substance P,insulin,MafA,and PDX-1 were decreased in DM rats(P<0.05).However,insulin and hAFSCs treatment could help to regain the expression of M2,M3,NGF,CGRP,substance P,MafA

关键词： amniotic fluid Bladder dysfunction Diabetes Insulin Stem cells

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Changes of Nerve Growth Factor in amniotic fluid and Correlation with Ventriculomegaly

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Chinese Medical Sciences Journal 2011年第2期26卷 109-112页

作者： Xiao-yan Xia Xing-hua Huang Yi-xin Xia Wei-hua Zhang Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China Department of Obstetrics and Gynecology General Hospital of Armed Police Forces Beijing 100039 China

Objective To detect the change of nerve growth factor (NGF) level in human amniotic fluid during gestation, and to explore the relationship between this change and fetal ventriculo-megaly (VM). Methods The studied subjects (collected from 2004 to 2007) were divided into four groups, including the second-trimester pregnancy group (n=113), third-trimester pregnancy group (n=110), fetal cerebral VM group (n=12), and healthy control group (n=12) which matched with the VM group in gestational weeks. The amniotic fluid specimens were obtained during amniocentesis or cesarean section. The NGF levels in amniotic fluid were detected with en-zyme-linked immunosorbent assay. Results A significantly negative correlation was found between gestational age and the NGF level in amniotic fluid (r= 0.6149, Pamniotic fluid may be a sensitive marker for fetal VM.

关键词： nerve growth factor amniotic fluid fetal ventriculomegaly

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Does cesarean section prevent adverse neonatal outcomes associated with meconium amniotic fluid?

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Gynecology and Obstetrics Clinical Medicine 2023年第4期3卷 241-244页

作者： Amene Ranjbar Sepideh Rezaei Ghamsari Elham Taeidi Vahid Mehrnoush Fatemeh Darsareh Fertility and Infertility Research Center Hormozgan University of Medical SciencesBandar AbbasIran Department of Midwifery and Reproductive Health Tehran University of Medical SciencesTehranIran Mother and Child Welfare Research Center Hormozgan University of Medical SciencesBandar AbbasIran Urology Department Northerm Ontario School of MedicineThunder BayOntarioCanada

Background Making decisions regarding the mode of delivery in the cases of meconium amniotic fluid(MAF)presents a challenge for healthcare *** aimed to compare the neonatal outcome of MAF cases delivered via cesarean section(CS)versus those delivered vaginally to determine if CS is a protective factor against the adverse neonatal *** In this retrospective study,we assessed singleton pregnant mothers diagnosed with MAF who gave birth at a tertiary hospital in Bandar Abbas,Iran,between January *** with certain adverse pregnancy conditions were excluded from the *** conditions included:abnormal fetal heart rate and pattern,bloody amniotic fluid,malpresentation,abnormal placentation,chorioamnionitis,intrauterine growth restriction,intrauterine fetal death,obstructed labor,and maternal *** MAF mothers were divided into two groups based on the method of delivery:those who had CS and those who had a normal vaginal delivery(NVD).Demographic factors,obstetrical factors,and neonatal outcomes were compared between the two *** Out of 746 MAF mothers,213(28.5%)underwent CS,while 533(71.4%)had *** were no significant differences between the groups in terms of demographic *** MAF mothers who had CS,66.2%were primiparous,and 33.8%were *** those who had NVD,35.1%were primiparous,and 64.9%were *** first and 5-min Apgar values,rates of asphyxia,neonatal intensive care unit(NICU)admission,and neonatal death were not statistically different between the two delivery *** rate of newborns who breastfed within the first hour did not differ depending on the mode of *** initial resuscitation steps were required more frequently in MAF mothers with NVD than in those with CS(11.1%vs.2.3%),no correlation was found between the mode of delivery and the need for resuscitation using logistic *** Our research findings suggest that there were no sup

关键词： Meconium amniotic fluid Neonatal outcomes

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Applications of human amniotic fluid stem cells in wound healing

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Chinese Medical Journal 2022年第19期135卷 2272-2281页

作者： Han Luo Zhen Wang Fang Qi Dali Wang Department of Plastic Surgery and Burns The Affliated Hospital of Zunyl Medical UniversityZunylGuizhou 563003China Department of Plastic Surgery and Burns Fuling Central HospitalChongqing 408000China

Complete wound regeneration preserves skin structure and physiological functions,including sensation and perception of stimuli,whereas incomplete wound regeneration results in fibrosis and *** fluid stem cells(AFSCs)would be a kind of cell population with self-renewing and non-immunogenic ability that have a considerable role in wound *** are easy to harvest,culture,and store;moreover,they are non-tumorigenic and not subject to ethical *** can differentiate into different kinds of cells that replenish the skin,subcutaneous tissues,and accessory ***,AFSCs independently produce paracrine effectors and secrete them in exosomes,thereby modulating local immune cell *** demonstrate anti-inflammatory and immunomodulatory properties,regulate the physicochemical microenvironment of the wound,and promote full wound ***,AFSCs are potential resources in stem cell therapy,especially in scar-free wound *** review describes the biological characteristics and clinical applications of AFSCs in treating wounds and provide new ideas for the treatment of wound healing.

关键词： amniotic fluid Stem cells Mesenchymal stromal cells Wound healing Cicatrix Hypertrophic Tissue engineering

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A Novel Method for the Prenatal Diagnosis of Cleft Palate Based on amniotic fluid Metabolites

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Chinese Journal of Plastic and Reconstructive Surgery 2020年第2期2卷 93-102页

作者： Wancong ZHANG Lewen JIANG Zhiwei SHEN Jiasheng CHEN Xiaoping ZHONG Weiping ZENG Jianda ZHOU Zhihao HE Shijie TANG Department of Plastic Surgery and Burn Center Second Affiliated HospitalShantou University Medical CollegeShantouGuangdongChina Department of Plastic Surgery Shenzhen Longgang District Maternity&Child Health care HospitalShenzhenGuangdongChina Department of Medical Imaging Second Affiliated Hospital of Shantou University Medical CollegeShantouGuangdongChina Department of Plastic and Reconstructive Surgery Central South University Third Xiangya HospitalChangshaHunanChina

Background and purpose The prenatal diagnosis of cleft palate is an important component of sequential therapy,but the relevant diagnostic methods are still *** aimed here,to explore the possibility of an early prenatal diagnosis of cleft palate by assessing metabolites in pregnant *** Twenty-four inseminated females were randomly divided into retinoic acid(RA)-treated(treated with retinoic acid at 10.5 gestation days)and control *** metabolites of the embryonic palatal tissue,maternal amniotic fluid,and serum were characterized using 9.4T magnetic resonance spectroscopy in ***,a predictive model was established through the principal component analysis(PCA),and the correlations between the metabolites of amniotic fluid and palatal tissue were explored using orthogonal-2 partial least squares(O2-PLS).Results The incidences of cleft palate were 100%and 0%in the RA-treated and control groups,respectively.A predictive PCA model with a high specificity and sensitivity was established for the early prenatal diagnosis of isolated cleft palate using amniotic fluid metabolic *** RA-treated and control mice,we found that two metabolites in the amniotic fluid and palatal tissue were *** showed the same trend in the palatal tissue and amniotic fluid,while choline showed opposite trends in the two ***,the data for serum metabolites could not be used to establish a prediction *** This study indicates that assessing the metabolites of amniotic fluid is a potential approach for the prenatal diagnosis of isolated cleft palate.

关键词： Metabolism amniotic fluid Serum Cleft Palate Prenatal Diagnosis

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A Comparison of amniotic fluid Index versus Single Deepest Vertical Pocket Measurement at Term as a Predictor of Adverse Perinatal Outcome

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Open Journal of Obstetrics and Gynecology 2022年第10期12卷 1062-1078页

作者： Hasitha Gunasingha Sardha Hemapriya Sachini Mendis Department of Obstetrics Teaching Hospital Kandy Sri Lanka

Introduction: Oligohydramnios is an important sign of fetal jeopardy and amniotic fluid index (AFI) and single deepest vertical pocket (SDVP) have been used to detect it. Objective: To compare AFI vs. SDVP at term as a predictor of adverse perinatal outcomes. Methods: A prospective observational study was conducted in Teaching Hospital Kandy, Sri Lanka for eight months from July 2015 to March 2016. 448 Singleton pregnancies admitted after 37 completed weeks were included. AFI ≤ 5 cm and SDVP < 2 cm were the exposure variables, which were related to outcome variables. Results: Mean AFI was 11.35 cm (SD = 5.15) and Mean SDVP was 4.07 cm (SD = 1.88). AFI and SDVP values showed a significant positive correlation (r = 0.954;p < 0.001). A significant percentage with low AFI needed induction of labour (RR 2.14, 95% CI 1.85 - 2.49). Low AFI was also a significant risk factor for not having an uneventful birth outcome (RR 2.682, 95% CI 1.082 - 6.642). Low SDVP was a significant risk factor for induction of labour (RR 1.83, 95% CI 1.434 - 2.334), operative delivery (RR 1.714, 95% CI 1.292 - 2.280), meconium-stained liquor (RR 2.67, 95% CI 1.342 - 5.308), and Apgar < 7 (RR 17.74, 95% CI 7.96 - 40.924). SDVP had better predictability than AFI for adverse perinatal outcomes. Conclusion: AFI better predicted oligohydramnios and subsequent labour induction than SDVP. Low SDVP was a risk factor for adverse perinatal outcomes (such as induction of labour, meconium-stained liquor, operative delivery, 5-minute Apgar less < 7, admission to special care baby units or perinatal deaths). In predicting adverse perinatal events, a higher potential was noted in SDVP method than AFI method. To determine the most predictive cut-off values of SDVP and AFI for each perinatal outcome, an in-depth experimental analysis is required in future research.

关键词： Perinatal Outcomes amniotic fluid Predictability AFI SDVP

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Noninvasive Fetal Lung Maturity Prediction Based on amniotic fluid Turbidity Using Ultrasonic Histogram Measurement Function

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Open Journal of Obstetrics and Gynecology 2023年第1期13卷 26-36页

作者： Kensuke Matsumoto Kaoru Yamawaki Kazufumi Haino Koji Nishijima Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital Niigata Japan

Background: amniotic fluid turbidity increases with fetal lung maturation due to vernix and lung surfactant micelles suspended in the amniotic fluid. This study focused on this phenomenon and evaluated the presence or absence of respiratory distress syndrome (RDS)/transient tachypnea of the newborn (TTN) by quantitatively assessing the brightness of the amniotic fluid turbidity using a noninvasive ultrasound histogram measurement function. Methods: We included cases of singleton pregnancies managed at the Niigata University Medical and Dental Hospital between November 2020 and March 2022. Histograms of amniotic fluid turbidity were measured at the center of the amniotic fluid depth, avoiding the fetus, placenta, and umbilical cord, with the gain setting set to 0, and the average value was obtained after three measurements. Histograms of fetal urine in the bladder were measured similarly. The value obtained by subtracting the fetal bladder brightness value from the amniotic brightness value based on histogram measurements was used as the final amniotic fluid brightness value. Results: We included 118 cases (16 of RDS/TTN and 102 of control). The gestational age of delivery weeks was correlated with amniotic fluid brightness (Spearman’s rank correlation coefficient was 0.344;p = 0.00014). amniotic fluid brightness values were significantly lower in the RDS/TTN group than in the control group (RDS/TTN: 16.2 ± 13.5, control: 26.3 ± 16.3;p = 0.020). The optimal cutoff value of amniotic fluid brightness to predict RDS/TTN was 20.3. For predicting RDS/TTN, the sensitivity, specificity, positive predictive value, and negative predictive value were 91.7%, 69.6%, 26.2%, and 94.1%, respectively. Conclusions: The quantitative value of the amniotic fluid brightness by histogram measurements may provide an easy and objective index for evaluating the presence or absence of RDS/TTN.

关键词： amniotic fluid Brightness Fetal Lung Histogram Turbidity

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