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第12届生物毒素研究及医药应用学术大会

作者： Xiao-Xia Zhao Yan-Yan Wu Xiang-Xiang Chen Hong-Ni Zhu Cheng-Hui Cao Lei Xi Ren-Hao Hou Qing-Hu Yang Yan-Heng Zhou Zhi-Hong Sun Xia Liu Zhan-Tao Bai College of Life Sciences & Research Center for Peptide Drugs Yanan University Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources Shaanxi Provincial Key Lab of Red Dates

alpha2-adrenergic receptor（alpha2-AR） is involved in the modulation of pain occurrence and *** reported that alpha2A-AR controlled the conduction and permeability of gap junction channels in heart muscle and cancer ***,whether functional interaction between alpha2A-AR and gap junction channels worked or not,is for from *** found that alpha2-AR agonist and gap junction blocker synergistically inhibited BmK I（scorpion Buthus martensii Karsch）-induced mirror image pain *** co-localization and qualitative assays revealed that the co-expression of alpha2A-AR and Cx43 was mainly distributed in *** addition,live cell imaging verified that neurotransmitter noradrenaline activated and opened astrocyte gap junctional ***,the noradrenaline-drived dye movement was blocked evidently by alpha2-AR agonist or gap junction blocker individually,and by them *** study indicates that the novel alpha2A-AR-Cx43 signaling pathways may mediate the induction,development,maintenance and recovery of mirror image *** findings would help to elucidate the persistence,chronicalization,diversities,personalization of pain mechanisms,and further provide some effective anti-pain strategies combing alpha2A-AR and connexin drugs.

关键词： Noradrenaline alpha2-adrenergic receptor Connexins Mirror image pain

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Dexmedetomidine:chaperone of anesthesia

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Clinical Research Communications 2021年第4期4卷 22-27页

作者： Jun Huang Cheng-Yun Hu Fei-Biao Dai Jia-Wu Wang Ming-Sheng Bao Chao-Liang Tang Department of Anesthesiology The People’s Hospital of ChizhouChizhou 247000China Department of Anesthesiology Anhui Provincial HospitalWannan Medical CollegeHefei 230001China Department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China

Aim:In this review,it will mainly focus on clarifying the pharmacology of dexmedetomidine and discussing the past,present and future clinical applications of dexmedetomidine as an adjunct in ***:We have searched and reviewed the articles about the use of dexmedetomidine in clinical anesthesia,intensive care unit(ICU),painless gastroenteroscopy and painless labor over the past two *** findings:Dexmedetomidine,a highly selective agonist of alpha2-adrenergic receptors(alpha2-AR),was primarily approved by the *** and Drug Administration(FDA)for sedation in ICU due to its pharmacological characteristics with sedative,analgesic and sympatholytic *** properties make up the limitations of anesthetics,and it produces a“dexmedetomidine assisted”anesthesia mode as an adjuvant combining with other anesthesia methods,which are all termed as“DEX+”.These new methods can reduce the anesthetics requirement but prolong the action period and alleviate the adverse reactions of anesthetics,thus improving the anesthesia more effectively and ***:Dexmedetomidine possesses the unique properties exerting synergistic effects and alleviating the side effects as an adjuvant in anesthesia through different administration *** is beneficial for the patients’long-term outcome and will be bound to be the leading innovator of anesthesia in future.

关键词： dexmedetomidine alpha2-adrenergic receptor anesthesia analgesia sedation

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