Dexmedetomidine:chaperone of anesthesia

作     者：Jun Huang Cheng-Yun Hu Fei-Biao Dai Jia-Wu Wang Ming-Sheng Bao Chao-Liang Tang 

作者机构：Department of AnesthesiologyThe People’s Hospital of ChizhouChizhou 247000China Department of AnesthesiologyAnhui Provincial HospitalWannan Medical CollegeHefei 230001China Department of AnesthesiologyThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China 

出 版 物：《Clinical Research Communications》 (临床研究通讯)

年 卷 期：2021年第4卷第4期

页      面：22-27页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：This study was supported by grants from the National Natural Science Foundation of China(No.81801175) the China Postdoctoral Science Foundation(No.2019M662179) the Anhui Province Postdoctoral Science Foundation(No.2019B324) the Fundamental Research Funds for the Central Universities(No.WK9110000044) 

主　　题：dexmedetomidine alpha2-adrenergic receptor anesthesia analgesia sedation 

摘      要：Aim:In this review,it will mainly focus on clarifying the pharmacology of dexmedetomidine and discussing the past,present and future clinical applications of dexmedetomidine as an adjunct in ***:We have searched and reviewed the articles about the use of dexmedetomidine in clinical anesthesia,intensive care unit(ICU),painless gastroenteroscopy and painless labor over the past two *** findings:Dexmedetomidine,a highly selective agonist of alpha2-adrenergic receptors(alpha2-AR),was primarily approved by the *** and Drug Administration(FDA)for sedation in ICU due to its pharmacological characteristics with sedative,analgesic and sympatholytic *** properties make up the limitations of anesthetics,and it produces a“dexmedetomidine assistedanesthesia mode as an adjuvant combining with other anesthesia methods,which are all termed as“DEX+.These new methods can reduce the anesthetics requirement but prolong the action period and alleviate the adverse reactions of anesthetics,thus improving the anesthesia more effectively and ***:Dexmedetomidine possesses the unique properties exerting synergistic effects and alleviating the side effects as an adjuvant in anesthesia through different administration *** is beneficial for the patients’long-term outcome and will be bound to be the leading innovator of anesthesia in future.