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Purified Wheat Gliadin Proteins as Immunoglobulin E Binding Factors in Wheat Mediated allergies

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American Journal of Plant Sciences 2011年第3期2卷 476-483页

作者： Jacek Waga Krystyna Obtulowicz Jerzy Zientarski Ewa Czarnobilska Andrzej Skoczowski Cereals Department Plant Breeding and Acclimatization InstituteKrakowPoland Department of Clinical and Environmental Allergology Collegium Medicum Jagiellonian UniversityKrakowPoland Institute of Biology Pedagogical UniversityKrakowPoland

Some wheat gliadin proteins are strong allergens that may cause various symptoms of food allergies and baker’s asthma. The most immunoreactive ω-5 gliadin fractions are the main allergens in wheat dependent exercise induced anaphylaxis (WDEIA). While the allergenicity of ω-5 is quite well understood, knowledge about α, β, γ and ω-1.2 gliadins is much more scanty. This study examines allergenic properties of other fractions as compared to ω-5. Gliadins were extracted from flour of winter wheat (Triticum aestivum L.) cultivar Ostka strzelecka. Purified samples representing proteins belonging to α, β, γ, ω-1.2 and ω-5 classes were isolated using preparative gel electrophoresis. Immuno-reactivity and allergenic properties of these proteins were analyzed by ELISA using sera from allergic patients with elevated sIgE (> 2KU/L), and by skin prick test (SPT). ELISA showed that ω-5 and ω-1.2 differed considerabely from α-, β- and γ-gliadins in respect of immunoreactivity. Responses of both ω-gliadins were almost twice as high as for other fractions. Significant differences were also observed among individual ω-gliadin fractions as evidenced by ANOVA. SPT showed that patient with symptoms of baker’s asthma and WDEIA had a positive results to all gliadins tested. Another patient with baker’s asthma (but not WDEIA) reacted positively only to ω-5 gliadins. In two patients with skin allergy SPT were negative with all analyzed proteins. Results show ω-1.2 gliadins to be almost as immunorective as ω-5. The α-, β- and γ-gliadins also recognize specific IgE antibodies, but their binding capacity is only about half that of ω-fractions. This kind of immunoreactivity could still be important since a cumulative effect of individual fractions may intensify disease symptoms in allergic patients.

关键词： allergies Gliadins Immunoreactivity Preparative A-PAGE Wheat

Coping Process in Children with Food allergies Developing during Early Childhood

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Health 2020年第1期12卷 38-62页

作者： Misa Suzuki Yuko Tomari Faculty of Nursing Seisen University Shiga Japan Faculty of Nursing Osaka Medical University Osaka Japan

This study aimed to clarify the coping process in children who developed food allergies in early childhood and evaluate the nursing support required to enable the acquisition of independent care behaviors in children with food allergies. Semi structured interviews were conducted on 24 children (aged 11 - 15 years) with food allergies using the modified grounded theory approach. The 11 categories were identified as coping mechanisms that these children used to deal with their early childhood food allergies. The coping process in children with food allergies involved transition from a stage of viewing their allergy with fear to a stage of considering the allergy as manageable and thus tackling allergens in their own way in the Life model. The process required obtaining peace of mind with support from others. In addition to emphasizing the threat of food allergies and risk aversion behaviors to these children, it is important that nurses also communicate viable proposals for alternative behaviors for the prohibited actions. The results also suggest that children in school age or older require support to help them recognize food allergy-related issues as problem-oriented coping tasks from the viewpoint of both Medical and Life models.

关键词： Food allergies Coping Care Behavior Modified Grounded Theory Approach

Building Trust: Children Experiences with Food allergies at Summer Camp

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Health 2016年第14期8卷 1423-1441页

作者： Sydney Leibel Nancy Fenton School of Public Health and Health Systems University of Waterloo Waterloo Canada McMaster Institute for Innovation & Excellence in Teaching & Learning (MIIETL) Mills Library L504 McMaster University Hamilton Canada

Introduction: The objective of this study was to explore the experiences and perceptions of children with food allergies at summer camp. Methods: Qualitative draw-and-tell interviews were conducted with 14 food allergic individuals aged 5 - 12 years to capture their lived experience with food allergies at summer camp. Results: Four key interdependent themes: trust, accommodation, proactive parents and coping strategies were identified in how children perceive their food allergies in unregulated summer camp environments.

关键词： Food Allergy Quality of Life Anaphylaxis allergies

Predictors of multiple injuries in individual distance runners:A retrospective study of 75,401 entrants in 4 annual races-SAFER XX

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Journal of Sport and Health Science 2022年第3期11卷 339-346页

作者： Sonja Swanevelder Nicola Sewry Martin Schwellnus Esme Jordaan Biostatistics Unit South African Medical Research CouncilParow 7575South Africa Sport Exercise Medicine and Lifestyle Institute(SEMLI)Faculty of Health SciencesUniversity of PretoriaPretoria 0081South Africa International Olympic Committee(IOC)Research Centre Pretoria 0081South Africa Emeritus Professor of Sport and Exercise Medicine Faculty of Health SciencesUniversity of Cape TownBellville 7535South Africa Statistics and Population Studies Department University of the Western CapeBellville 7535South Africa

Background There are limited data on factors that predict an increased risk of multiple injuries among distance *** objective of this study was to determine risk factors that are predictive of individual runners with a high annual multiple injury risk(MIR).Methods A retrospective,cross-sectional study at 4 annual(2012-2015)Two Oceans 21.1 km and 56.0 km races in South Africa with 75,401 consenting race ***-related injury data were collected retrospectively through an online pre-race medical screening *** average number of injuries for each runner every year was calculated by taking a runner's race entry history and injury history into account and categorizing entrants into 4 MIR categories(high,intermediate,low,and very low(reference)).Multiple logistic regression modeling(odds ratios)was used to determine whether the following factors were predictive of a high MIR(average>1 injury/year):demographics,training and racing,chronic-disease history(composite chronic disease score(CCDS)),and history of *** Of all entrants,9.2%reported at least 1 injury,and 0.4%of entrants were in the high MIR category;the incidence rate was 2.5 injuries per 10 runner-years(95%confidence interval(95%CI):2.4-2.7).Significant factors predictive of runners in the high MIR category were:running for>20 years:OR=2.0(95%CI:1.3-3.1;p=0.0010);a higher CCDS:OR=2.2(95%CI:2.0-2.4;pallergies:OR=2.8(95%CI:2.0-3.8;p20 years and those with multiple chronic diseases or a history of allergies were at higher risk of multiple running-related *** high-risk group can be targeted for further study and possible injury-prevention interventions.

关键词： allergies Chronic diseases Multiple injuries Risk factors SAFER study

ECM1 controls Th2 cell egress from lymph nodes through re-expression of S1P1

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ECM1 controls Th2 cell egress from lymph nodes through re-ex...