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Ameliorative effects of monascin from red mold rice on alcoholic liver injury and intestinal microbiota dysbiosis in mice

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Food Bioscience 2022年第6期50卷 752-764页

作者： Li Wu Wenlong Li Guimei Chen Ziyi Yang Xucong Lv Lizhong Zheng Jinyuan Sun Lianzhong Ai Baoguo Sun Li Ni College of Chemistry Fuzhou UniversityFuzhouFujian350108PR China Institute of Food Science and Technology College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian350108PR China Beijing Laboratory for Food Quality and Safety Beijing Technology and Business UniversityBeijing100048PR China School of Medical Instruments and Food Engineering University of Shanghai for Science and TechnologyShanghai200093PR China Zhejiang Sanhe Bio-Tech Co. Ltd.JiangshanZhejiang324100PR China

Monascus-fermented red mold rice(RMR)has excellent physiological efficacy on lipid metabolism and liver *** study investigated the ameliorative effects of monascin(MS)from RMR on alcoholic liver injury(ALI)in mice,and further illustrated its mechanism of *** indicated that dietary MS intervention obviously ameliorated lipid metabolism and liver function in mice with *** addition,MS intervention alleviated alcohol-induced oxidative stress in the liver by reducing the hepatic activities of lactate dehydrogenase(LDH)and hepatic levels of malondialdehyde(MDA),increasing the hepatic activities of catalase(CAT),superoxide dismutase(SOD),alcohol dehydrogenase(ADH)and hepatic levels of glutathione(GSH).16S rRNA amplicon sequencing showed that excessive drinking had a significant effect on the composition of the gut microbiota in *** intervention was beneficial to ameliorate intestinal microbiota dysbiosis by elevating the proportion of Lactobacillus,Lachnospiraceae_UCG-006,Coriobacteriales,etc.,but decreasing the proportion of Staphylococcus,Muribaculaceae,Desulfovibrionaceae,***,correlation analysis indicated that the key intestinal bacterial taxa intervened by MS were closely related to some biochemical indicators of lipid metabolism,liver function and oxidative ***,liver metabolomics analysis revealed that dietary MS supplementation significantly regulated the levels of liver metabolites involved in taurine and hypotaurine metabolism,riboflavin metabolism,and purine metabolism,***,MS intervention regulated gene transcription and protein expression associated with lipid metabolism and oxidative stress in the *** short,these findings suggest that MS mitigates alcohol-induced hepatic oxidative damage through modulating the intestinal microbiome and liver metabolic pathway,and thus can be served as a functional component to prevent alcoholic liver disease.

关键词： Monascus Monascin alcoholic liver injury Intestinal microbiome liver metabolomics

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Metadoxine inhibits the infiltration of macrophages and neutrophils into liver tissue in acute alcoholic liver injury

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Journal of Chinese Pharmaceutical Sciences 2022年第1期31卷 47-54页

作者： Wen Jiang Yilin Wei Qing Wen Gexin Shi Hengli Zhao Central Research Laboratory the Second Hospital of Shandong UniversityJinan 250013China Department of Clinical Research Center Central Hospital Affiliated to First Medical UniversityJinan 250033China

Alcohol consumption causes significant liver damage,including hepatitis,fibrosis,cirrhosis,and even primary liver ***(MTDX)is considered to be a beneficial treatment for alcoholic liver disease(ALD)because it accelerates the metabolism and elimination of ***,the underlying mechanism is not well ***,the rat model of ALD was developed by feeding with 50%ethanol at the dose of 5 g/kg,and samples of serum and liver tissue were collected to test the levels of liver injury and inflammation and evaluate the hepatoprotective function of MTDX in alcohol-induced liver *** investigation on the infiltration of immune cells was performed to understand the potential hepatoprotective mechanism of MTDX in the ALD *** results showed that MTDX attenuated liver injury,evidenced by decreased levels of alanine transaminase(ALT),aspartate aminotransferase(AST),and alkaline phosphatase(ALP).Meanwhile,the liver proinflammatory environment was improved after MTDX treatment,evidenced by decreased levels of TNF-α,IL-6,and NLRP3 in the liver ***,inhibited infiltrations of macrophages and neutrophils were observed in MTDX-treated ALD rats compared with the untreated ALD *** results indicated that MTDX played an important role in preventing the progression of ALD,and the underlying mechanisms might be related to its function of attenuating liver inflammation by inhibiting immune cell infiltration.

关键词： Metadoxine alcoholic liver injury Macrophages Neutrophils Inflammatory

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Optimization of Extraction Conditions of Pomegranate Peel Polyphenols and Its Protective Effect on Acute alcoholic liver injury in Mice

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Agricultural Biotechnology 2023年第4期12卷 16-21,40页

作者： Dianwu KONG Miao CAI Jing LI Xinyu HAO Xinhao YANG Xianglong WANG Liyan LI Medical School Huanghe Science and Technology CollegeZhengzhou 450063China

[Objectives]This study was conducted to explore the optimization of ultrasonic-assisted organic solvent extraction of pomegranate peel polyphenols(PPPs),and to study the protective effect of PPPs on acute alcoholic liver injury in mice.[Methods]The optimal extraction conditions of PPPs were determined by single factor and orthogonal experiments,and an acute alcoholic liver injury model in mice was *** was used as the positive control group to investigate the protective effect of low,medium and high doses of PPPs on acute alcoholic liver injury.[Results]The optimum extraction process parameters were followed as 60%ethanol concentration,solid-liquid ratio of 1:40(w/v),extraction temperature of 50℃,and extraction time of 1.5 h,and the yield was 1.42%.The results of animal experiments showed that PPPs could effectively reduce the degree of alcoholic liver injury in mice,reduce the levels of serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST),and reduce the inflammation and necrosis of liver tissue in ***,the total polyphenols from pomegranate peel also significantly reduced the expression levels of malondialdehyde(MDA),tumor necrosis factor(TNF-α)and interleukin-6(IL-6)in mice,and increased the levels of superoxide dismutase(SOD)and reduced glutathione(GSH)in liver tissue of mice,indicating its antioxidant and anti-inflammatory effects,further illustrating its protective effect on alcoholic liver injury.[Conclusions]PPPs could reduce the expression levels of TNF-α,IL-6 and MDA in mice,and increase the expression levels of SOD and GSH to achieve the protective effect on acute alcoholic liver injury in *** study will provide new ideas for the development of new anti-alcoholic liver injury drug resources.

关键词： Pomegranate peel polyphenols Extraction condition optimization alcoholic liver injury Oxidative stress Inflammatory factor

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Protective effect of Solanum Nigrum Linn green fruit ethanolic extract on alcoholic liver injury in mice

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Journal of Polyphenols 2024年第3期6卷 91-97页

作者： Xiaoli Wang Ning Wang Nan Yang Xiaoshu Zhang Faculty of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China

alcoholic liver injury is a liver disease caused by excessive alcohol consumption,which can lead to chronic liver disease *** Nigrum Linn taste bitter,cold,has the effect of clearing heat and detoxification,promoting blood and *** Nigrum Linn fruit contains a variety of antioxidant enzymes,can remove the body produced by aerobic metabolism harmful *** this paper,a model of alcohol-induced liver injury in C57BL/6 mice was established to evaluate the protective effect of Solanum Nigrum Linn green fruit(SNGF)ethanolic extract on alcohol-induced liver injury.H&E staining and oil red O(ORO)staining showed that hepatic lobules were clearly demarcated,vacuoles were significantly reduced and lipid droplets were reduced in SNGF ethanolic extract treatment *** levels of TC,TG,LDH,TBA,AKP,ALT and AST were decreased in the SNGF ethanolic extract treatment group,and SNGF ethanolic extract could clear reactive oxygen species(ROS)in *** content was signifi cantly decreased after SNGF ethanolic extract treatment,while superoxide dismutase(SOD)and GSH-Px contents were increased after SNGF ethanolic extract *** results suggest that SNGF ethanolic extract has a protective effect on alcohol-induced liver injury.

关键词： Solanum Nigrum Linn green fruit ethanolic extract alcoholic liver injury protective effect

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Protective effect of gingerol dropping pills against alcoholic liver injury in mice

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中国药理学与毒理学杂志 2017年第5期31卷 482-482页

作者： LI Li ZHANG Zhi-yuan QI Si-jia GAO Yong-feng WANG Lei Institute of Pharmacology Taishan Medical University

OBJECTIVE To prepare gingerol dropping pills and to investigate its protective effect on alcoholic liver injury. METHODS The prescription was selected by orthogonal design method and the effect of the option and ratio of ground substance,the temperature of drug. The hardness,circular degree,the tail formation and the dissolution time were studied. Totally 40 KM mice were randomly divided into control group,model group,gingerol dropping pill group(400 mg·kg^(-1)·d^(-1)) and positive control group(bifendate,150 mg·kg^(-1)·d^(-1)) of 10 mice each. The mice from the model and two drug groups were administrated with liqueur[0.15 mL/(10 g·d)]daily by gavage for 3 weeks,Two hours later,drug group mice were treated corresponding gingerol dropping pill and bifendate. Meanwhile,the control group were gavaged same amount of normal saline. Finally,when the model of acute alcoholic liver injury was established on the 22 stday,Biochemical indicators of ocular blood in mice were *** also observed the change of liver morphology. RESULTS Under optimum conditions,we can obtain dropping pills having circular shape,touching with hardness and short dissolution time. Compared with the control group,the levels of alanine transaminase(ALT),glutamic-oxaloacetic transaminase(AST) and malondialdehyde(MDA) in model group were obviously increased(Pliver disorders,hepatic lobule fusion,accompanying a large number of patchy sample liver cell vacuoles,various sizes of fat vacuoles appeared in cytoplasm and inflammatory cell infiltration were visible around the central vein. On the contrary,compared with the model group,drug groups attenuated or even reversed hepatic pathological changes. Form gingerol dropping pill group,an increase in hepatic SOD activity and serum ALT and AST activities were found and a significant decrease in hepatic MDA content were also observed(P<0.01). CONCLUSION T

关键词： gingerol dropping pills alcoholic liver injury antioxidation

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Betaine inhibits Toll-like receptor 4 expression in rats with ethanol-induced liver injury

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World Journal of Gastroenterology 2010年第7期16卷 897-903页

作者： Shi, Qing-Zhao Wang, Lu-Wen Zhang, Wei Gong, Zuo-Jiong Wuhan Univ Renmin Hosp Dept Infect Dis Wuhan 430060 Hubei Province Peoples R China

AIM:To test whether ethanol feeding could induce Toll-like receptor 4(TLR4)responses,assess the hepatoprotective effect of betaine and its inhibitive effect on TLR4 in animal models of alcoholic liver ***:Forty-eight female Sprague-Dawley rats were randomly divided into four groups as control,model,low and high dose betaine *** control group,all rats were fed with high fat-containing diet plus ethanol and fish oil gavages for 8 *** was administered intragastrically after exposure of ethanol for 4 *** changes of liver histology were *** expression of TLR4 mRNA and protein was detected by RT-PCR and Western blotting,*** serum aminotransferase activity alanine transarninase(ALT),aspartate aminotransferase(AST),serum endotoxin,and liver inflammatory factors tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-18(IL-18)were also ***:Compared with control group,rats of model group developed marked liver injury,accompanied by an increase of ALT(159.41±7.74 U/L vs 59.47± 2.34 U/L,Pliver after chronic ethanol consumption(1.45±0.07 vs 0.44±0.04,Pliver *** expression levels of TLR4 mRNA

关键词： Betaine Toll-like receptor 4 alcoholic liver injury Expression

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Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice

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Acta Pharmaceutica Sinica B 2017年第5期7卷 583-592页

作者： Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi School of Pharmaceutical Sciences Sun Yat-sen University Department of Pharmacy School of Medicine Shenzhen University Shenzhen Bao'an Maternal and Child Health Hospital

Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently *** Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway.

关键词： alcoholic liver injury Schisandra sphenanthera Wuzhi Tablet NRF2-ARE Oxidative stress

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IL-6-deficient Mice Are Susceptible to Ethanol-induced Hepatic Steatosis:IL-6 Protects against Ethanol-induced Oxidative Stress and Mitochondrial Permeability Transition in the liver

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Cellular & Molecular Immunology 2004年第3期1卷 205-211页

作者： Osama El-Assal Won-HoKim SvetlanaRadaeva Section on liver Biology Laboratory of Physiologic StudiesNational Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthBethesdaMD 20892USA.

Interleukin-6(IL-6)-deficient mice are prone to ethanol-induced apoptosis and steatosis in the liver;however, the underlying mechanism is not fully *** dysfunction caused by oxidative stress is an early event that plays an important role in the pathogenesis of alcoholic liver ***,we hypothesize that the protective role of IL-6 in ethanol-induced liver injury is mediated via suppression of ethanol-induced oxidative stress and mitochondrial *** test this hypothesis,we examined the effects of IL-6 on ethanol-induced oxidative stress,mitochondrial injury,and energy depletion in the livers of IL-6(-/-)mice and hepatocytes from ethanol-fed *** consumption leads to stronger induction of malondialdehyde(MDA) in IL-6(-/-)mice compared to wild-type control mice,which can be corrected by administration of *** vitro, IL-6 treatment prevents ethanol-mediated induction of reactive oxygen species(ROS),MDA,mitochondrial permeability transition(MPT),and ethanol-mediated depletion of adenosine triphosphate(ATP)in hepatocytes from ethanol-fed *** of IL-6 in vivo also reverses ethanol-induced MDA and ATP depletion in ***,IL-6 treatment induces metallothionein protein expression,but not superoxide dismutase and glutathione peroxidase in cultured *** conclusion,IL-6 protects against ethanol-induced oxidative stress and mitochondrial dysfunction in hepatocytes via induction of metailothionein protein expression,which may account for the protective role of IL-6 in alcoholic liver *** & Molecular Immunology.2004;1(3):205-211.

关键词： IL-6 alcoholic liver injury oxidative stress mitochondria metallothionein

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Inula britannica ameliorates alcohol-induced liver injury by modulating SIRT1-AMPK/Nrf2/NF-κB signaling pathway

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Chinese Herbal Medicines 2024年第4期16卷 667-678页

作者： Zhennan Meng Mengyuan Li Xiaoli Wang Kuo Zhang Chunfu Wu Xiaoshu Zhang Faculity of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Objective: Inula britannica is a traditional Chinese medicinal and functional food with various effects such as anti-liver injury, hypoglycemia, antioxidants, and anti-tumor. The aim of this study was to investigate the protective effects and mechanisms of the ethanolic extract of I. britannica(EEIB) on alcohol-induced liver injury in ***: Fifty-six female C57BL/6 mice were randomly divided into seven groups: control group(Con),ethanol feeding model group(EtOH), Silibinin positive treatment group(EtOH + Silibinin 100 mg/kg),EEIB treatment group(EtOH + EEIB 100, 200, and 400 mg/kg), and EEIB control group(EEIB 400 mg/kg). The National Institute on Alcohol Abuse and Alcoholism(NIAAA) ethanol-feeding model was used to study the effects of EEIB on alcohol-induced lipid metabolism, inflammation, oxidative stress, and fibril formation in mice by histopathological evaluation, immunofluorescence staining, Western blotting analysis and molecular ***: EEIB reduced liver indices to different degrees to normal levels and improved liver morphology in mice. EEIB inhibited alcohol-induced liver injury by activating the sirtuin 1(SIRT1)-adenosine monophosphate-activated protein kinase(AMPK) signaling pathway in the liver of alcohol-fed mice, in which sesquiterpenes may be the potential active ingredients, and also down-regulated the expression of alpha-smooth muscle actin(a-SMA), collagen alpha(Collagen I), tumor necrosis factor-alpha(TNFa) and attenuated alcohol-induced liver injury. In addition, EEIB also activated the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway, which alleviated alcohol-induced liver injury at the level of oxidative stress. Notably, the EEIB control group demonstrated that EEIB had no toxic effects in mice. EEIB reduced alcoholic liver injury in a dose-dependent manner. Its therapeutic efficacy was comparable to, if not better than, that of Silibinin when administered at a dose of 400 mg/***: EEIB showed sig

关键词： alcoholic liver injury inflammation Inula britannica L. sesquiterpenes SIRT1-AMPK/Nrf2

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Research Progress on Pharmacological Effects of Betulin

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Medicinal Plant 2022年第4期13卷 78-80页

作者： Shuxin LI Chenghao JIN College of Forestry Northeast Forestry UniversityHarbin 150040China College of Life Science and Biotechnology Heilongjiang Bayi Agricultural UniversityDaqing 163319China

Betulin is main component of triterpenoids in bark extract of Betula platyphylla,and has antibacterial,antiviral,liver protecting,cholagogic,antitumorus and other *** paper reviews the pharmacological effects and mech... 详细信息

关键词： Betulin Pharmacological effect alcoholic liver injury Reperfusion injury after myocardial ischemia Antitumorus effect

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