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alcohol consumption and dry eye syndrome: a Metaanalysis

International Journal of Ophthalmology(English edition) 2016年第10期9卷 1487-1492页

作者： Yong-Sheng You Nai-Bin Qu Xiao-Ning Yu Eye Center Second Affiliated HospitalSchool of MedicineZhejiang University

AIM：To quantify the association between alcohol consumption and dry eye syndrome（DES） with Meta-analysis of published case-control and cross-sectional studies. METHODS： Three databases were screened for potentially eligible studies through Nov.30,2015,Pub Med,Web of Science,and the Cochrane *** ratios（ORs） were pooled with 95% confidence intervals（CIs） to evaluate the relationship between alcohol consumption and DES *** analyses were performed according to diagnostic criteria,publication year,sample size,alcohol intake and adjusted ***： A total of 10（9 case-control and 1 crosssectional） studies from 8 articles were included in this *** pooled results showed that alcohol consumption would significantly increase the risk of DES（OR 1.15,95% CI： 1.02-1.30）,and the results were independent of smoking,hypertension,diabetes and thyroid disease *** the results of subgroup analyses indicated an increased incidence of DES diagnosed by typical DES symptoms and positive objective tests together（OR 1.18,95% CI： 1.01-1.39）among drinkers,but not by typical DES symptoms alone（OR 1.11,95% CI： 0.94-1.32）.What＇s more,any drinkers were at higher risk of suffering from DES（OR 1.33,95%CI： 1.31-1.34）,while heavy drinkers not（OR 1.01,95% CI：0.86-1.18）.CONCLUSION： The present Meta-analysis suggests that alcohol consumption may be a significant risk factor for ***-induced peripheral neuropathymay falsely reduce the prevalence of DES among heavy *** prospective studies of alcohol consumption and DES risk are needed to confirm our results.

关键词： dry eye syndrome alcohol consumption Meta-analysis

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alcohol consumption promotes arsenic absorption but reduces tissue arsenic accumulation in mice

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Eco-Environment & Health 2023年第3期2卷 107-116页

作者： Hongyu Wang Albert L.Juhasz Yaosheng Zhang Lizhu Zhang Lena Q.Ma Dongmei Zhou Hongbo Li State Key Laboratory of Pollution Control and Resource Reuse Jiangsu Key Laboratory of Vehicle Emissions ControlSchool of the EnvironmentNanjing UniversityNanjing 210023China Future Industries Institute University of South AustraliaMawson LakesSouth Australia 5095Australia Department of Nanxin Pharm Nanjing 210000China Institute of Soil and Water Resources and Environmental Science College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China

alcohol consumption alters gut microflora and damages intestinal tight junction barriers,which may affect arsenic(As)oral *** this study,mice were exposed to arsenate in the diet(6μg/g)over a 3-week period and gavaged daily with Chinese liquor(0.05 or 0.10 mL per mouse per day).Following ingestion,78.0%and 72.9%of the total As intake was absorbed and excreted via urine when co-exposed with liquor at daily doses of 0.05 or 0.10 mL,significantly greater than when As was supplied alone(44.7%).alcohol co-exposure significantly altered gut microbiota but did not significantly alter As biotransformation in the intestinal tract or *** lower relative mRNA expression was observed for genes encoding for tight junctions in the ileum of liquor co-exposed mice,contributing to greater As bioavailability attributable to enhanced As absorption via the intestinal paracellular ***,As concentration in the liver,kidney,and intestinal tissue of liquortreated mice was decreased by 24.4%-42.6%,27.5%-38.1%,and 28.1%-48.9%compared to control *** was likely due to greater renal glomerular filtration rate induced by alcohol,as suggested by significantly lower expression of genes encoding for renal tight *** addition,in mice gavaged daily with 0.05 mL liquor,the serum antidiuretic hormone level was significantly lower than control mice(2.83±0.59 vs.5.40±1.10 pg/mL),suggesting the diuretic function of alcohol consumption,which may facilitate As elimination via *** results highlight that alcohol consumption has a significant impact on the bioavailability and accumulation of As.

关键词： Arsenic speciation alcohol consumption Oral bioavailability Tissue accumulation Tight junctions

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Association of alcohol consumption with aortic aneurysm and dissection risk:results from the UK Biobank cohort study

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World Journal of Emergency Medicine 2024年第6期15卷 465-474页

作者： Yaowen Liang Guoxiang Zou Dingchen Wang Weiyue Zeng Jiarui Zhang Xiaoran Huang Miao Lin Cong Mai Fei'er Song Yuelin Zhang Jinxiu Meng Hongliang Feng Yu Huang Xin Li Department of Emergency Medicine Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Shantou University Medical College Shantou 515063China South China University of Technology Guangzhou 510080China Medical Big Data Center Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Critical Care Medicine Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Center for Sleep and Circadian Medicine the Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510080China Department of Ophthalmology Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China

BACKGROUND:Previous studies have reported inconsistent results with positive,negative,and J-shaped associations between alcohol consumption and the hazard of aortic aneurysm and dissection(AAD).This study aimed to examine the connections between weekly alcohol consumption and the subsequent risk of ***:The UK Biobank study is a population-based cohort *** alcohol consumption was assessed using self-reported questionnaires and the congenital risk of alcohol consumption was also evaluated using genetic risk score(GRS).Cox proportional hazards models were used to estimate hazard ratios(HRs)with 95% confidence intervals(CIs)for the associations between alcohol consumption and *** sensitivity analyses were performed to assess the robustness of the ***:Among the 388,955 participants(mean age:57.1 years,47.4% male),2,895 incident AAD cases were documented during a median follow-up of 12.5 *** with never-drinkers,moderate drinkers(adjusted HR:0.797,95%CI:0.646-0.984,Palcohol consumption on AAD,but are limited to participants younger than 65 years and women.

关键词： alcohol consumption Aortic aneurysm and dissection Genetic risk score Cohort study UK Biobank

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Relationship between alcohol consumption and clinical manifestation of patients with fatty liver:a single-center study

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Hepatobiliary & Pancreatic Diseases International 2011年第3期10卷 276-279页

作者： International Health Care Center (Wang XF) and Department of Gastroenterology (Yue M),First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China [a] International Health Care Center First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China [b] Department of Gastroenterology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China

BACKGROUND:Fatty liver is a common chronic liver disease *** is associated with an increasing morbidity in China in recent *** aim of this study was to analyze the effect of drinking alcohol on the hemoglobin and biochemical values of patients with fatty ***:We investigated the clinical and laboratory data of 669 patients with fatty *** the 669 patients,166 consumed alcohol more than 60 g per week for at least 2 years,and 503 did not have a history of long-term alcohol *** further analyzed the relationship between alcohol consumption and clinical characteristics of these ***:The values of aspartate transaminase (AST),gammaglutamyl transpeptidase (GGT),and hemoglobin in the long-term consumption group were significantly higher than those in the non long-term consumption group (Palcohol consumption,the values of GGT and hemoglobin in patients with light alcohol consumption were significantly higher than those in non alcohol consumers (Palcohol consumption is associated with significantly increased values of AST,GGT,and hemoglobin in patients with fatty liver,suggesting their potential roles in hepatic steatosis.

关键词： alcohol consumption fatty liver hemoglobin aspartate transaminase gamma-glutamyl transpeptidase

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alcohol consumption in China before and during COVID-19:preliminary results from an online retrospective survey

Alcohol consumption in China before and during COVID-19:prel...

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2020年浙江省医学会精神病学学术大会浙江省医师协会精神科医师分会第十三届年会

作者： Yunfei Wang Heli Lu Maorong Hu Shiyou Wu Jianhua Chen Ling Wang Tao Luo Zhenzhen Wu Yueheng Liu Jinsong Tang Wei Chen Qijian Deng Yanhui Liao Department of Psychiatry the Second Xiangya HospitalCentral South University National Clinical Research Center of Mental Disorders Department of Psychosomatic Medicine the Second Affiliated Hospital of Nanchang University Department of psychiatry the First Affiliated Hospital of Nanchang University The Third Affiliated Hospital of Guizhou Medical University Shanghai Clinical Research Center for Mental Health Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of Medicine Florence Nightingale Faculty of Nursing Midwifery & Palliative CareKing's College London Department of Social Medicine and Health Management Xiangya School of Public HealthCentral South University Jiangxi Mental Hospital Department of Psychiatry Sir Run Run Shaw HospitalSchool of MedicineZhejiang University Key Laboratory of Medical Neurobiology of Zhejiang Province Addictions Department Institute of PsychiatryPsychology and NeuroscienceKing's College London

Background:alcohol is an important aspect of the Chinese culture,and alcohol use has been traditionally accepted in *** with stress,anxiety and depression may use more *** people reported symptoms of anxiety and depression during the outbreak of ***,people may drink more alcohol during the outbreak of COVID-19 than before ***:An online retrospective survey was conducted on a total sample of 2229 *** behaviors before and during COVID-19,current risk drinking and hazardous drinking,and the association between high risk drinking and mental health problems(depression,anxiety and stress) were assessed via self-reported measures of alcohol Use Disorders Identification Test(AUDIT) and The 21-item Depression Anxiety Stress Scales(DASS-21).Results:This study found that,compared with before COVID-19,alcohol consumption was slightly decreased during COVID-19(from 3.5 drinkers to 3.4 drinkers,p=0.035) in overall ***(78.7%) alcohol drinker were *** and during COVID-19,males consumed more drinkers per week(4.2 and 4.0 drinkers VS 1.3 and 1.2 drinker),had higher percentage of heavy drinker(8.1% and 7.7% VS 4.4% and 2.7%),and more drinking days per week(2.1 and 2.1 days VS 1.0 and 0.9 days).Males also had more risk drinking(43.2% VS 9.3%) and hazardous drinking(70.2% VS 46.6%) than female *** study also found that high risk drinking predicted anxiety in ***:This study suggests a slight reduction of alcohol consumption during ***,hazardous drinking is common,especially among male alcohol *** consumed more alcohol,had more risk and hazardous drinking than female counterparts both before and during *** health policy makers should pay more attention to develop population-based effective strategy to prevent harmful alcohol consumption.

关键词： alcohol consumption heavy drinking risk drinking before and during COVID-19 retrospective survey

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