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The distribution of IL-17 and Foxp3 is associated with adverse pregnancy outcome in mice infected with Toxoplasma gondii

The distribution of IL-17 and Foxp3 is associated with adver...

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第九届全国免疫学学术大会

作者： Xuemei Hu Haixia Zhang Medicine & Pharmacy Research Center Department of ImmunologyBinzhou Medical College

Bacgroud:Although Treg/Th17 imbalance is reported to play critical roles in the development of adverse pregnancy outcomes in Toxoplasma gondii(T.gondii)-infected mice,information on the detailed mechanisms is still limited.Problem:In the present study,we investigated the expression level of Interleukin(IL)-17 and Foxp3 in relation to the consequent inflammatory response in the placentas ofT.gondii-infected mice,which have adverse pregnancy outcomes.Methods of study:HE staining for inflammation and PMNs in placentas from T.gondii-infected and non-infected mice was performed and the expression levels of IL-17 and Foxp3 in placenta from T.gondii-infected and non-infected mice were evaluated by flow cytometry and immunohistochemical staining.Moreover,the information on vertical transmission of the parasite was analyzed.Results:Data indicated that the pathological changes of placentas from mice with adverse pregnancy outcome caused by T.gondii-infection were characterized by extensive ischemia,necrosis and inflammation,accompanied with higher PMN score in the placentas compared to the non-infected mice.The MIF of IL-17 or Foxp3 were significantly higher or lower than that of non-infected mice respectively.This distribution of IL-17 and Foxp3 was also confirmed by immunohistochemistry analysis.Additionally,the tachyzoites of T.gondii and neutrophils containing the parasite were observed in placentas from the infected mice.Conclusion:The imbalance of inflammation and anti-inflammation,which was caused by the changes of distribution of IL-17 and Foxp3 in the placenta,induced elevated inflammatory response,which disrupted the maternal-foetal immunological tolerance and led to adverse pregnancy outcomes consequently.

关键词： IL-17 Foxp3 T.gondii adverse pregnant outcome

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The role of sHLA-G on the abnormal pregnant outcome induced by Toxoplasma gondii infection

The role of sHLA-G on the abnormal pregnant outcome induced ...

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第九届全国免疫学学术大会

作者： Xuemei Hu Haifeng Wang Medicine & Pharmacy Research Center Department of ImmunologyBinzhou Medical College

Background:T.gondii can affect fetus via vertical transmission and lead to adverse pregnant outcomes.The soluble human leukocyte antigen molecules G(sHLA-G)play a key role in the success of pregnancy through interacting with decidual natural killer cell(dNK)inhibitory receptors at the maternal-fetal interface.Objective:In this study,we aimed to investigate the role of sHLA-G on the abnormal pregnancy outcomes induced byToxoplasma gondii through the vivo and vitro experiments.Materials and methods:Concentration of the sHLA-G in BeWo culture supernatant,and the Qa-2 in the placenta supernatant,amniotic fluid and serum of pregnant CBL/6 mice were all analyzed by ELISA.Levels of NKG2A in mouse and KIR2DL4 expressed on human dNK cells were analyzed by flow cytometry,respectively.Results:Results showed that the levels of Qa-2 and its ligand NKG2A of mice in infected group were significantly higher than that controls(padverse pregnant outcomes.

关键词： sHLA-G Qa-2 KIR2DL4 NKG2A T.gondii adverse pregnant outcome

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