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Management of adult growth hormone deficiency at Peking Union Medical College Hospital:A Survey among Physicians

Chinese Medical Sciences Journal 2016年第3期31卷 168-172页

作者： Hong-bo Yang Meng-qi Zhang Hui Pan Hui-juan Zhu Department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College Department of Pediatrics Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

Objective To evaluate physicians' attitude and knowledge about the management of adult growth hormone deficiency(AGHD) at Peking Union Medical College Hospital and impact factors associated with better *** A 21-question anonymous survey was distributed and collected at Peking Union Medical College Hospital,a major teaching hospital in Chinese Academy of Medical *** of physicians' educational background,clinical training,patient workload per year and continuing medical education in AGHD were *** associated with appropriate answers were further analyzed by multivariate regression *** One hundred and eighteen internal medicine residents,endocrine fellows,attending physicians and visiting physicians responded to the *** them,44.9% thought that AGHD patients should accept recombinant human growth hormone replacement ***,56.8% selected insulin tolerance test and growth hormone-releasing hormone-arginine test for the diagnosis of *** regression analysis of physician demographic data,educational background,and work experience found no consistent independent factors associated with better decision-making,other than continued medical education,that were associated with treatment *** The physicians' reported management of AGHD in this major academic healthcare center in Beijing was inconsistent with current *** quality continued medical education is required to improve Chinese physician management of AGHD.

关键词： adult growth hormone deficiency management continued medical education

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Role of bisphosphonates in osteoporosis caused by adult growth hormone deficiency

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中南大学学报（医学版） 2024年第6期49卷 839-847页

作者： CHENG Zhiling LI Jie CHEN Zhongpei REN Wei Department of Endocrinology Chongqing Traditional Chinese Medicine HospitalChongqing 400011 Department of Endocrinology First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

In recent years,growth hormone and insulin-like growth factors have become key regulators of bone metabolism and remodeling,crucial for maintaining healthy bone mass throughout *** have shown that adult growth hormone deficiency leads to alterations in bone remodeling,significantly affecting bone microarchitecture and increasing fracture *** recombinant human growth hormone replacement therapy can mitigate these adverse effects,improving bone density,and reduce fracture risk,its effectiveness in treating osteoporosis,especially in adults with established growth hormone deficiency,seems *** inhibit bone resorption by targeting farnesyl pyrophosphate synthase in osteoclasts,and clinical trials have confirmed their efficacy in improving ***,for adult growth hormone deficiency patients with osteoporosis,the use of bisphosphonates alongside growth hormone replacement therapy is recommended.

关键词： growth hormone adult growth hormone deficiency osteoporosis bisphosphonates insulin-like growth factor 1 skeleton

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