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Fate determination of fetal leydig cells

Frontiers in Biology 2011年第1期6卷 12-18页

作者： Qing WEN Yixun LIU Fei GAO State Key Laboratory of Reproduction Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Graduate School of the Chinese Academy of Sciences Beijing 100049China

leydig cell(LC)is one of the most important somatic cell types in testis,which localized in the interstitium between seminiferous *** major function of leydig cells is to produce steroid hormone,*** differentiation exhibits a biphasic pattern in rodent testes,which are divided into two different temporal mature populations,fetal leydig cells(FLCs)and adult leydig cells(ALCs).FLCs are transiently present in fetal testes and undergo involution or degeneration after *** are completely devoid and replaced by ALCs in adult *** to ALCs,FLCs display unique morphology,ultrastructure and *** origin of FLCs has been debated for many years,but it is still a *** factors have been reported regulating the specification,proliferation and differentiation of *** degenerate in a few weeks postnatally,however,the underlying mechanism is still *** this review,we will focus on the fate determination of FLCs,and summarize the resent progress on the morphology,ultrastructure,function,origin and involution of FLCs.

关键词： fetal leydig cells adult leydig cells fate determination

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Alterations in gene expression and steroidogenesis in the testes of transient cerebral ischemia in male rats

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Chinese Medical Journal 2012年第12期125卷 2168-2172页

作者： ZHAO Bing-hai GU0 Yan-qin LI Hong-zhi LIU Jie-ting WU Dan YUAN Xiao-huan LI Rong-wen GUAN Li-xin Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy Mudanjiang Medical University MudanjiangHeilongjiang 157001 China HongqiHospital Mudanjiang Medical University MudanjiangHeilongjiang 157001 China Division of Fundamental Neurobiology Toronto Western HospitalResearch Institute University Health Network Toronto OntarioCanada

Background Serum testosterone levels have been found lower in acute ischemic stroke male patients. However, the exact mechanism remains unclear. In the present study, we measured serum testosterone levels, steroidogenesis- related genes and leydig cells number in experimental transient cerebral ischemia male rats to elucidate the mechanism. Methods The middle cerebral arteries of adult male Sprague-Dawley rats were sutured for 120 minutes and then sacrificed after 24 hours. Blood was collected for measurement of serum testosterone, follicular stimulating hormone and estradiol levels, and testes were collected for measurement of steroidogenesis-related gene mRNA levels and number of leydig cells. Results Serum testosterone levels in rats after cerebral ischemia were significantly lower （0.53±0.16） ng/ml, n=7, mean＋SE） compared with control （（2.33±0.60） ng/ml, n=7）, while serum estradiol and follicular stimulating hormone levels did not change. The mRNA levels for luteinizing hormone receptor （Lhcgr）, scavenger receptor class B member 1 （Scarbl）, steroidogenic acute regulatory protein （STAR）, cholesterol side chain cleavage enzyme （Cyplla1）, 3β-hydroxysteroid dehydrogenase 1 （HSD3β1）, 17α-hydroxylase/20-1yase （Cyp17α1） and membrane receptor c-kit （kit） were significantly downregulated by cerebral ischemia, while luteinizing hormone, Kit ligand （KitL）, 1713-hydrosteroid dehydrogenase 3 （HSD17β3） and 5α-reductase （Srd5α1） were not affected. We also observed that, relative to control, the leydig cell number did not change. Conclusions These results indicate that transient cerebral ischemia in the brain results in lower expression levels of steroidogenesis-related genes and thus lower serum testosterone level. Transient cerebral ischemia did not lower the number of leydig cells.

关键词： cerebral ischemia testosterone adult leydig cells

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