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Clinical effects of phospholipase D2 in attenuating acute pancreatitis

World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-Wei Niu Guo-Chao Zhang Wu Ning Hai-Bin Liu Hua Yang Chao-Feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(Pacute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration acute pancreatitis Retrospective analysis Inflammatory response

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Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis

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World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing Zhang Chun-Lin Ou Department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

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acute pancreatitis in pregnancy

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World Journal of Gastroenterology 2009年第45期15卷 5641-5646页

作者： Capecomorin S Pitchumoni Balaji Yegneswaran Drexel University College of Medicine and Robert Wood Johnson Medical School New BrunswickNJ 08901 United States Department of Gastroenterology Saint Peter's University Hospital New BrunswickNJ 08901 United States Drexel University College of Medicine Saint Peter's University Hospital New BrunswickNJ 08901 United States

acute pancreatitis (AP) is a rare event in pregnancy, occurring in approximately 3 in 10 000 pregnancies. The spectrum of AP in pregnancy ranges from mild pancreatitis to serious pancreatitis associated with necrosis, abscesses, pseudocysts and multiple organ dysfunction syndromes. Pregnancy related hematological and biochemical alterations infl uence the interpretation of diagnostic tests and assessment of severity of AP. As in any other disease associated with pregnancy, AP is associated with greater concerns as it deals with two lives rather than just one as in the non-pregnant population. The recent advances in clinical gastroenterology have improved the early diagnosis and effective management of biliary pancreatitis. Diagnostic studies such as endoscopic ultrasound, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography and therapeutic modalities that include endoscopic sphincterotomy, biliary stenting, common bile duct stone extraction and laparoscopic cholecystectomy are major milestones in gastroenterology. When properly managed AP in pregnancy does not carry a dismal prognosis as in the past.

关键词： acute pancreatitis Pregnancy pancreatitis in pregnancy

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acute pancreatitis induced by transarterial chemoembolization:a single-center experience of over 1500 cases

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 93-98页

作者： Wong Hoi She Albert CY Chan Tan To Cheung Kenneth SH Chok See Ching Chan Ronnie TP Poon Chung Mau Lo Division of Hepatobiliary & Pancreatic Surgery and Liver Transplantation Department of SurgeryThe University of Hong Kong

BACKGROUND： acute pancreatitis is a relatively rare but po- tentially lethal complication after transarterial chemotherapy. This study aimed to review the complications such as acute pancreatitis after transarterial chemotherapy with or without embolization for hepatocellular carcinoma. METHODS： A total of 1632 patients with hepatocellular car- cinoma who had undergone transarterial chemoembolization from ]anuary 2000 to February 2014 in a single-center were reviewed retrospectively. We investigated the potential com- plications of transarterial chemoembolization, such as acute pancreatitis and acute pancreatitis-related complications. RESULTS： Of the 1632 patients with hepatocellular carcinoma who had undergone 5434 transarterial chemoembolizations, 1328 were male and 304 female. The median age of these pa- tients was 61 years. Most （79.6%） of the patients suffered from HBV-related hepatoceUular carcinoma. The median tumor size was 5.2 cm. Of the 1632 patients, 145 patients underwent transarterial chemoembolization with doxorubicin elut- ing bead, making up a total of 538 episodes. The remaining patients underwent transarterial chemoembolization with cisplatin. Seven （0.4%） patients suffered from acute pancre- atitis post-chemoembolization. Six patients had chemoembo- lization with doxorubicin and one had chemoembolization with cisplatin. Patients who received doxornbicin eluting bead had a higher risk of acute pancreatitis [6/145 （4.1%） vs 1/1487 （0.1%）, P〈0.0001]. Two patients had anatomical arterial variations. Four patients developed acute pancreatitis- related complications including necrotizing pancreatitis （n=3） and pseudocyst formation （n=1）. All of the 4 patients resolved after the use of antibiotics and other conservative treatment. Three patients had further transarterial chemoembolization without any complication. CONCLUSIONS： acute pancreatitis after transarterial chemo- embolization could result in serious complications, especially after treatment wit

关键词： transarterial chemoembolization acute pancreatitis hepatocellular carcinoma

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acute pancreatitis associated left-sided portal hypertension with severe gastrointestinal bleeding treated by transcatheter splenic artery embolization:a case report and literature review

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第6期14卷 549-554页

作者： Zhi-yu LI Bin LI Yu-lian WU Qiu-ping XIE Department of Surgery the Second Affiliated HospitalSchool of MedicineZhejiang University

Left-sided portal hypertension(LSPH)followed by acute pancreatitis is a rare condition with most patients being *** cases where gastrointestinal(GI)bleeding is present,however,the condition is more complicated and the mortality is very high because of the difficulty in diagnosing and selecting optimal treatment.A successfully treated case with severe GI bleeding by transcatheter splenic artery embolization is reported in this *** patient exhibited severe uncontrollable GI bleeding and was confirmed as gastric varices secondary to LSPH by enhanced computed tomography(CT)scan and *** embolization,the bleeding stopped and stabilized for the entire follow-up period without any severe *** conclusion,embolization of the splenic artery is a simple,safe,and effective method of controlling gastric variceal bleeding caused by LSPH in acute pancreatitis.

关键词： Left-sided portal hypertension(LSPH) Gastric varices acute pancreatitis Gastrointestinal bleeding Splenic artery embolization(SAE)

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acute pancreatitis associated with intravenous administration of propofol:evaluation of causality in a systematic review of the literature

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Gastroenterology Report 2019年第1期7卷 13-23,I0001页

作者： Samir Haffar Ravinder Jeet Kaur Sushil Kumar Garg Joseph A.Hyder M.Hassan Murad Barham K.Abu Dayyeh Fateh Bazerbachi Digestive Center for Diagnosis&Treatment 29 Ayar StreetDamascusSyrian Arab Republic Division of Gastroenterology and Hepatology Mayo Clinic200 First Street SWRochesterMN 55905USA Division of Anesthesiology and Perioperative Medicine Mayo Clinic200 First Street SWRochesterMN 55905USA Division of Health Care Policy and Research Mayo Clinic200 First Street SWRochesterMN 55905USA

acute pancreatitis(AP)associated with intravenous administration of propofol has been described with unknown causal *** therefore assessed this causality in a systematic *** databases were searched on 16 August 2017;studies were appraised and selected by two reviewers based on a priori *** causality was evaluated with the Naranjo scale and Badalov *** identified 18 studies from 11 countries with a total of 21 patients,and the majority had adequate methodological *** median age was 35 years(range,4–77)and 10(48%)were ***,propofol was administrated in 8 patients as sedative along with induction/maintenance of anesthesia in 13 patients;median dose was 200 mg,with intermediate latency(1–30 days)in 14(67%).Serum triglycerides were>1000 mg/dL in four *** AP was observed in four patients(19%).AP recurrence occurred in one out of two patients who underwent *** related to AP was 3/21(14%).Propofol was the probable cause of AP according to the Naranjo scale in 19 patients(89%).Propofol-induced AP has a probable causal relation and evidence supports Badalov class *** is not the only mechanism by which propofol illicit ***-induced AP was severe in 19%of patients with a mortality rate related to AP of 14%.Future research is needed to delineate whether this risk is higher if combined with other procedures that portend inherent risk of pancreatitis such as endoscopic retrograde cholangiopancreatography.

关键词： acute pancreatitis drug-induced pancreatitis propofol systematic review

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acute pancreatitis:Etiology and common pathogenesis

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World Journal of Gastroenterology 2009年第12期15卷 1427-1430页

作者： Guo-Jun Wang Chun-Fang Gao Dong Wei Cun Wang Si-Qin Ding Institute of Digestive Surgery and Department of General Surgery 150 Hospital of Chinese PLA Gaoxin District Luoyang 471031 Henan Province China

acute pancreatitis is an inflammatory disease of the *** etiology and pathogenesis of acute pancreatitis have been intensively investigated for centuries *** causes of acute pancreatitis have been discovered,but the pathogenetic theories are *** most common cause of acute pancreatitis is gallstone impacting the distal common bile-pancreatic *** majority ofinvestigators accept that the main factors for acute billiary pancreatitis are pancreatic hyperstimulation and bile-pancreatic duct obstruction which increase pancreatic duct pressure and active trypsin *** pancreatitis occurs when intracellular protective mechanisms to prevent trypsinogen activation or reduce trypsin activity are ***,little is known about the other acute *** hypothesize that acute biliary pancreatitis and other causes of acute pancreatitis possess a common *** hyperstimulation and pancreatic duct obstruction increase pancreatic duct pressure,active trypsin reflux,and subsequent unregulated activation of trypsin within pancreatic acinar *** activation within the pancreas leads to auto-digestion of the gland and local *** the hypothesis is confirmed,traditional therapeutic strategies against acute pancreatitis may be *** of pancreatic duct pressure should be advocated in the treatment of acute pancreatitits which may greatly improve its outcome.

关键词： acute pancreatitis Pathogenesis Etiology Pancreatic duct obstruction Pancreatichyperstimulation Pancreatic duct pressure

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acute pancreatitis with pulmonary embolism:A case report

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World Journal of Clinical Cases 2021年第4期9卷 904-911页

作者： Xue-Ling Fu Fa-Ke Liu Ming-Dong Li Chang-Xue Wu Emergency Intensive Care Unit The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Critical Care Medicine The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Radiology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND acute pancreatitis(AP)is a common critical disease of the digestive system that is often associated with multiple *** complications are relatively rare and are one of the causes of *** complicated with pulmonary embolism(PE)is even rarer,and there are no reports of AP complicated with PE in elderly *** SUMMARY We describe a rare case of AP complicated with PE and review the literature.A 68-year-old woman was diagnosed with AP due to widespread abdominal *** the course of treatment,the patient had shortness of breath and progressively worsening dyspnea without chest pain or hemoptysis with a progressive increase in D-dimer and fibrin degradation *** failure and right heart failure occurred,and refractory hypoxemia remained after mechanical *** chest computed tomography revealed a small amount of left pleural effusion and external pressure atelectasis in the lower lobe of the left lung but no findings that could lead to refractory *** Doppler ultrasound indicated pulmonary hypertension and extensive venous thrombosis in the lower *** computed tomography angiography finally suggested pulmonary *** patient’s dyspnea symptoms disappeared after anticoagulation *** During the diagnosis and treatment of AP,it is necessary to dynamically monitor D-dimer and consider PE.

关键词： acute pancreatitis Pulmonary embolism Vein thrombosis D-dimer Diagnosis Case report

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acute pancreatitis with hypercalcemia caused by primary hyperparathyroidism associated with paraneoplastic syndrome:A case report and review of literature

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World Journal of Clinical Cases 2021年第29期9卷 8906-8914页

作者： Long Yang Yue Lin Xiang-Qun Zhang Bo Liu Jun-Yu Wang Department of Emergency Medicine Clinical Research Center Beijing Chao-Yang HospitalCapital Medical University&Beijing Key Laboratory of Cardiopulmonary Cerebral ResuscitationBeijing Chaoyang District Gongti South Street 100020China Department of Radiology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Although acute pancreatitis associated with hyperparathyroidism has occasionally been reported,acute pancreatitis with metabolic encephalopathy caused by hyperparathyroidism combined with paraneoplastic syndrome is an extremely rare entity and poorly described in the *** SUMMARY We present a case of a 56-year-old female with upper abdominal discomfort and intermittent nausea and vomiting for 1 wk,without apparent abdominal pain or bloating,no jaundice and decreased blood pressure at the *** patient was ultimately diagnosed with moderately severe acute pancreatitis(according to the revised Atlanta classification of acute pancreatitis)combined with metabolic encephalopathy secondary to hypercalcemia caused by primary hyperparathyroidism associated with paraneoplastic *** active treatment of acute pancreatitis,massive fluid resuscitation,resection of parathyroid and uterine malignant tumors,neoadjuvant chemotherapy and other treatments,her serum calcium eventually returned to the normal *** patient was successfully discharged from *** This is the first case of acute pancreatitis caused by primary hyperparathyroidism associated with paraneoplastic syndrome.

关键词： acute pancreatitis Humoral hypercalcemia Primary hyperparathyroidism Paraneoplastic syndrome Case report

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acute pancreatitis:A review of diagnosis,severity prediction and prognosis assessment from imaging technology,scoring system and artificial intelligence

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World Journal of Gastroenterology 2023年第37期29卷 5268-5291页

作者： Jian-Xiong Hu Cheng-Fei Zhao Shu-Ling Wang Xiao-Yan Tu Wei-Bin Huang Jun-Nian Chen Ying Xie Cun-Rong Chen Intensive Care Unit The Affiliated Hospital of Putian UniversityPutian 351100Fujian ProvinceChina School of Pharmacy and Medical Technology Putian UniversityPutian 351100Fujian ProvinceChina Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine Putian UniversityPutian 351100Fujian ProvinceChina Department of Critical Care Medicine Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina School of Mechanical Electrical and Information EngineeringPutian UniversityPutian 351100Fujian ProvinceChina

acute pancreatitis(AP)is a potentially life-threatening inflammatory disease of the pancreas,with clinical management determined by the severity of the ***,severity prediction,and prognosis assessment of AP typically involve the use of imaging technologies,such as computed tomography,magnetic resonance imaging,and ultrasound,and scoring systems,including Ranson,acute Physiology and Chronic Health Evaluation II,and Bedside Index for Severity in AP *** tomography is considered the gold standard imaging modality for AP due to its high sensitivity and specificity,while magnetic resonance imaging and ultrasound can provide additional information on biliary obstruction and vascular *** systems utilize clinical and laboratory parameters to classify AP patients into mild,moderate,or severe categories,guiding treatment decisions,such as intensive care unit admission,early enteral feeding,and antibiotic *** the central role of imaging technologies and scoring systems in AP management,these methods have limitations in terms of accuracy,reproducibility,practicality and *** advancements of artificial intelligence(AI)provide new opportunities to enhance their performance by analyzing vast amounts of clinical and imaging *** algorithms can analyze large amounts of clinical and imaging data,identify scoring system patterns,and predict the clinical course of ***-based models have shown promising results in predicting the severity and mortality of AP,but further validation and standardization are required before widespread clinical *** addition,understanding the correlation between these three technologies will aid in developing new methods that can accurately,sensitively,and specifically be used in the diagnosis,severity prediction,and prognosis assessment of AP through complementary advantages.

关键词： acute pancreatitis Imaging technology Scoring system Artificial intelligence Severity prediction Prognosis assessment

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