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Stimulus-secretion-coupling in a central synapse measured by membrane capacitance and postsynaptic EPSCs in mouse brain slices

Stimulus-secretion-coupling in a central synapse measured by...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Amy YANG Claire Xi ZHANG Department of Physiology University of TorontoTorontoCanada Institute of Molecule Medicine Peking University

＜正＞A fundamental question is whether AP encodes affect total neurotransmitter release in CNS *** a previous study,we showed that action potential（AP） encodes（time organization of APs） can modulate total "presynaptic" secretion in isolated adrenal chromaffin *** Calyx of Held is a large glutamatergic synapse in mammalian auditory brainstem and participates in sound *** secretion on its presynaptic terminal can be recorded by membrane capacitance（Cm） in mouse brainstem ***,we study modulation of evoked secretion by AP encodes in calyx synapses in mouse brain *** stimulus pattern is defined by a AP "code function" F（N,m,f,d） with "N" as number of total APs,"m" as number of AP bursts,"f" as AP frequency,and "d" as interval time between two AP *** results are:（1） F（100,m,100 Hz,0.2 s）-induced presynaptic capacitance was facilitated by 62%at m = 4 vs 1,termed "mfacilitation";（2） The total postsynaptic EPSC-integration,which is proportional to total glutamate release,was facilitated by 33%;（3） The smaller "m-facilitation" measured by post synaptic EPSCs *** capacitance suggests,that the average quantal size of glutamate release from single synaptic vesicle is accompanied with the "m-facilitation" in the CNS synapses,implying that the facilitated release from recycled and late-released vesicles has lower glutamate concentration during a intensive synaptic *** conclude that synaptic transmission is modulated by AP encodes in mouse CNS.

关键词： membrane capacitance brain slice action potential pattern

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Modulation of dopamine release by stimulus pattern in striatum in vivo

Modulation of dopamine release by stimulus pattern in striat...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Shi-Rong WANG~1,Wei YAO~1,Hong-Ping HUANG~1,Jing-Zhi ZHENG~1,Panli ZUO~1,Claire Xi ZHANG~1,Bao-Ming LI~2, Zhuan ZHOU~1 1 Institute of Molecular Medicine,Peking University,Beijing 100871 2 Institute of Neurobiology,Fudan University,Shanghai 200433,China

＜正＞A long-standing question in how the nervous system processes information is whether patterns of action potentials（APs）,in addition to their mean frequency,have specific effects on neurotransmitter *** previous studies on different AP patterns showed that the number of AP bursts effectively modulate cell secretion in cultured adrenal chromaffin ***,it is not clear how such patterns modulate transmitter release in the central nervous system in *** answer this question,amperometry was used to measure dopamine release in the rat striatum,in response to electrical stimulation of the medial forebrain *** stimulus pattern was defined by the four parameters, number（"N"） and frequency（"f’） of stimuli pulses,number of bursts（"m"）,and inter-burst interval（"d"）.We found that for a given "N",in addition to "f’,"m" effectively modulated dopamine ***,this "burst effect" was modulated by stimulus numbers,frequency and inter-burst *** dopamine signals were measured also in mice. Cocaine and nomifensine,inhibitors of dopamine transporter,enhanced the burst *** proposed that the secretion efficiency modulated by stimuli code may play an important role in information transfer in neural networks in vivo.

关键词： Dopamine release striatum in vivo action potential pattern

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