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Sperm-specific protein ACTL7a as a biomarker for fertilization outcomes of assisted reproductive technology

Asian Journal of Andrology 2022年第3期24卷 260-265页

作者： Tian-Ying Yang Ying Chen Guo-Wu Chen Yi-Si Sun Zhi-Chao Li Xiao-Rong Shen Yi-Ni Zhang Wen He Dan Zhou Hui-Juan Shi Ai-Jie Xin Xiao-Xi Sun Shanghai Ji Ai Genetics and IVF Institute Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China NHC Key Lab of Reproduction Regulation(Shanghai Institute for Biomedical and Pharmaceutical Technologies) School of PharmacyFudan UniversityShanghai 200032China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China Department of Endocrinology and Reproductive Medicine Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China

Obtaining high-quality embryos is one of the key factors to improve the clinical pregnancy rate of assisted reproductive technologies(ART).So far,the clinical evaluation of embryo quality depends on embryo morphology.However,the clinical pregnancy rate is still low.Therefore,new indicators are needed to further improve the evaluation of embryo quality.Several studies have shown that the decrease of sperm-specific protein actin-like 7a(ACTL7a)leaded to low fertilization rate,poor embryo development,and even infertility.The aim of this study was to study whether the different expression levels of ACTL7a on sperm can be used as a biomarker for predicting embryo quality.In this study,excluding the factors of severe female infertility,a total of 281 sperm samples were collected to compare the ACTL7a expression levels of sperms with high and low effective embryo rates and analyze the correlation between protein levels and in-vitro fertilization(IVF)laboratory outcomes.Our results indicated that the ACTL7a levels were significantly reduced in sperm samples presenting poor embryo quality.Furthermore,the protein levels showed a significant correlation with fertilization outcomes of ART.ACTL7a has the potential to be a biomarker for predicting success rate of fertilization and effective embryo and the possibility of embryo arrest.In conclusion,sperm-specific protein ACTL7a has a strong correlation with IVF laboratory outcomes and plays important roles in fertilization and embryo development.

关键词： actin-like 7a assisted reproductive technology biomarker embryo quality in‑vitro fertilization outcomes

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