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Corneal endothelial cells and acoustic cavitation in phacoemulsification

World Journal of Clinical Cases 2023年第8期11卷 1712-1718页

作者： Kai Chen Wen-Ya Xu Si-Si Sun Hong-Wei Zhou Department of Ophthalmology Lianshui County People's HospitalHuai’an 223400Jiangsu ProvinceChina Department of Ophthalmology Huai’an 82 HospitalHuai'an 223001Jiangsu ProvinceChina Department of Industrial Engineering Tsinghua UniversityBeijing 100084China

Postoperative complications of phacoemulsification,such as corneal edema caused by human corneal endothelial cell(CEC)injury,are still a matter of concern.Although several factors are known to cause CEC damage,the influence of ultrasound on the formation of free radicals during surgery should be considered.Ultrasound in aqueous humor induces cavitation and promotes the formation of hydroxyl radicals or reactive oxygen species(ROS).ROS-induced apoptosis and autophagy in phacoemulsification have been suggested to significantly promote CEC injury.CEC cannot regenerate after injury,and measures must be taken to prevent the loss of CEC after phacoemulsification or other CEC injuries.Antioxidants can reduce the oxidative stress injury of CEC during phacoemulsification.Evidence from rabbit eye studies shows that ascorbic acid infusion during operation or local application of ascorbic acid during phacoemulsification has a protective effect by scavenging free radicals or reducing oxidative stress.Both in experiments and clinical practice,hydrogen dissolved in the irrigating solution can also prevent CEC damage during phacoemulsification surgery.Astaxanthin(AST)can inhibit oxidative damage,thereby protecting different cells from most pathological conditions,such as myocardial cells,luteinized granulosa cells of the ovary,umbilical vascular endothelial cells,and human retina pigment epithelium cell line(ARPE-19).However,existing research has not focused on the application of AST to prevent oxidative stress during phacoemulsification,and the related mechanisms need to be studied.The Rho related helical coil kinase inhibitor Y-27632 can inhibit CEC apoptosis after phacoemulsification.Rigorous experiments are required to confirm whether its effect is realized through improving the ROS clearance ability of CEC.

关键词： Cataract Phacoemulsification Corneal endothelial cells Ultrasound acoustic cavitation Oxidative stress Antioxidant

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Correlation between microbubble-induced acoustic cavitation and hemolysis in vitro

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Chinese Physics B 2011年第2期20卷 316-320页

作者：张春兵刘政郭霞生章东 The Traditional Chinese Medicine Hospital of Jiangsu Province Institute of acoustics Key Laboratory of Modern Acoustics (Nanjing University)Ministry of EducationNanjing University Xinqiao Hospital Third Military Medical University

Microbubbles promise to enhance the efficiency of ultrasound-mediated drug delivery and gene therapy by taking advantage of artificial cavitation nuclei. The purpose of this study is to examine the ultrasound-induced hemolysis in the application of drug delivery in the presence of microbubbles. To achieve this goal, human red blood cells mixed with microbubbles were exposed to 1-MHz pulsed ultrasound. The hemolysis level was measured by a flow cytometry, and the cavitation dose was detected by a passive cavitation detecting system. The results demonstrate that larger cavitation dose would be generated with the increase of acoustic pressure, which might give rise to the enhancement of hemolysis. Besides the experimental observations, the acoustic pressure dependence of the radial oscillation of microbubble was theoretically estimated. The comparison between the experimental and calculation results indicates that the hemolysis should be highly correlated to the acoustic cavitation.

关键词： acoustic cavitation passive cavitation detection microbubbles hemolysis

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Effect of inertial acoustic cavitation on antibiotic efficacy in biofilms

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Applied Mathematics and Mechanics(English Edition) 2021年第10期42卷 1397-1422页

作者： M.GHASEMI S.SIVALOGANATHAN Department of Applied Mathematics University WaterlooWaterloo N2L 3G1Canada

Bacterial biofilms can lead to chronic infections,increase tolerance to antibiotics and disinfectants,resistance to phagocytosis,and other components of the body’s immune system.Biofilm formation is implicated in the persistence of staphylococcal infections and chronic Pseudomonas aeruginosa lung infections in cystic fibrosis(CF)patients(which can result from biofilm-growing mucoid strains).Conventional treatments utilize aggressive antibiotic prophylaxis/therapy to prevent/eliminate biofilms,followed by chronic suppressive therapy.Recently,the use of enzymes to dissolve the biofilm matrix was investigated,in addition to quorum sensing inhibitors to increase biofilm susceptibility to antibiotics.Here,we propose a novel strategy,utilizing ultrasound-induced inertial cavitation,to increase antibiotic efficacy.The wall shear stress at the biofilm interface is calculated,and viscoplastic constitutive equations are used to examine the biofilm response to the mechanical stress.Our simulations suggest that the maximum biofilm detachment occurs at high pressure/low frequency,and the mechanical disruption can affect the biochemical processes inside the biofilm resulting in vulnerability to antibiotics.

关键词： biofilm mechanical disruption mathematical model acoustic cavitation bubble collapse antibiotic

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Ordered mesoporous carbon-silica frameworks confined magnetic mesoporous TiO_(2) as an efficient catalyst under acoustic cavitation energy

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Journal of Materiomics 2020年第1期6卷 45-53页

作者： Pengpeng Qiu Tao Zhao Jeehyeong Khim Wan Jiang Lianjun Wang Wei Luo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsDonghua UniversityShanghai201620China School of Civil Environmental and Architectural EngineeringKorea UniversitySeoul136-701Republic of Korea

Herein,we report a biphase stratification strategy that enables the encapsulation of magnetic mesoporous TiO_(2) inside an ordered mesoporous C/SiO_(2) framework.The obtained composites exhibit high surface areas(up to 600 m^(2) g^(-1)),large perpendicular pore sizes(up to 9 nm)and a strong magnetic response(~10.0 emu g^(-1)),presenting significantly enhanced degradation activities toward pentachlorophenol(PCP)and bisphenol-A(BPA)under acoustic cavitation energy.The remarkable performance is ascribed to the synergistic effect from the unique structural modulation:1)The large ordered mesopores favors the mass transfer,2)The mesoporous C/SiO_(2) frameworks promote the adsorption of organic pollutants and enrich them close to the TiO_(2) surface and 3)The special spatial arrangement of different components facilitates the generation of cavitation bubbles,leading to the increase in the overall hydroxyl-radical-production rate.Moreover,owing to the effective confinement,the as-prepared materials possess an excellent stability and durability.More importantly,the catalysts can easily be recovered by a magnet and show an excellent reusability.It is believed that these results could provide an important insight for the development of an efficient,stable and facile recoverable catalyst for the acoustic chemical process.

关键词： Fe_(3)O_(4)@mTiO_(2)@mC/SiO_(2) acoustic cavitation Magnetic separation Mechanical stability

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Boiling heat transfer with acoustic cavitation

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Progress in Natural Science:Materials International 2002年第6期 70-73页

作者： ZHOU Dingwei and LIU Dengying(Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100080, China) Institute of Engineering Thermophysics Chinese Academy of Sciences Beijing 100080 China

The effects of acoustic cavitation and nanometer granule on boiling heat transfer of horizontal circular copper tube are investigated experimentally and theoretically using acetone as the working fluid according to the boiling procedure. The results show that heat transfer can be enhanced or weakened by generation of the cavitation bubble or addition of the nanometer granules, respectively. The mechanisms of the effects are analyzed.

关键词： acoustic cavitation boiling heat transfer nanometer grannie.

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Sonochemical synthesis of photocatalysts and their applications

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Journal of Materials Science & Technology 2022年第28期123卷 243-256页

作者： Kezhen Qi Chunqiang Zhuang Manjie Zhang Peyman Gholami Alireza Khataee College of Pharmacy Dali UniversityDali 671000China Beijing Key Lab of Microstructure and Property of Advanced Materials Faculty of Materials and ManufacturingInstitute of Microstructure and Property of Advanced MaterialsBeijing University of TechnologyBeijing 100124China Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034China Department of Chemistry University of HelsinkiHelsinki 00014Finland Department of Applied Chemistry Faculty of ChemistryResearch Laboratory of Advanced Water and Wastewater Treatment ProcessesUniversity of TabrizTabriz 51666-16471Iran Department of Environmental Engineering Gebze Technical UniversityGebze41400Turkey

Sonochemical synthesis has flourished significantly in the last few decades for the preparation of photocatalysts.A large number of photocatalysts have been prepared through sonochemical techniques.This review highlights the scope of sonochemistry in the preparation of photocatalysts,and their applications in energy production and environmental remediation.Beside,the sonochemical degradation of pollutants is discussed in detail.The progress made in sonochemical synthesis and the future perspective for this technique are summarized here.This review may create more enthusiasm among researchers to pay extra attention to the sonochemical synthesis of materials and add their useful contribution to the investigation of new materials for photocatalytic and other applications.This will propel this technique toward commercial sonosynthesis of nanomaterials.

关键词： Sonochemistry acoustic cavitation Photocatalysis Energy production Environmental remediation

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Distribution pattern of acoustic and streaming field during multi-source ultrasonic melt treatment process

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中国铸造:英文版 2023年第5期20卷 452-460页

作者： Xiao-gang Fang Qi Wei Tian-yang Zhang Ji-guang Liu You-wen Yang Shu-lin Lü Shu-sen Wu Yi-qing Chen School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China Engineering Research Center of High-Performance Copper Alloy Materials and Processing Ministry of EducationHefei 230009China State Key Laboratory of Material Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China

The ultrasonic melt treatment(UMT)is widely used in the fields of casting and metallurgy.However,there are certain drawbacks associated with the conventional process of single-source ultrasonic(SSU)treatment,such as the fast attenuation of energy and limited range of effectiveness.In this study,the propagation models of SSU and four-source ultrasonic(FSU)in Al melt were respectively established,and the distribution patterns of acoustic and streaming field during the ultrasonic treatment process were investigated by numerical simulation and physical experiments.The simulated results show that the effective cavitation zone is mainly located in a small spherical region surrounding the end of ultrasonic horn during the SSU treatment process.When the FSU is applied,the effective cavitation zone is obviously expanded in the melt.It increases at first and then decreases with increasing the vibration-source spacing(Lv)from 30 mm to 100 mm.Especially,when the Lv is 80 mm,the area of effective cavitation zone reaches the largest,indicating the best effect of cavitation.Moreover,the acoustic streaming level and flow pattern in the melt also change with the increase of Lv.When the Lv is 80 mm,both the average flow rate and maximum flow rate of the melt reach the highest,and the flow structure is more stable and uniform,with the typical morphological characteristics of angular vortex,thus significantly expanding the range of acoustic streaming.The accuracy of the simulation results was verified by physical experiments of glycerol aqueous solution and tracer particles.

关键词： four-source ultrasound acoustic cavitation streaming field vibration-source spacing

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Ultrasound-Assisted Solidifi cation of a Cu–Cr Alloy

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Acta Metallurgica Sinica(English Letters) 2022年第12期35卷 2082-2088页

作者： Siruo Zhang Huijun Kang Min Cheng Zongning Chen Zhicheng Wang Enyu Guo Jiehua Li Tongmin Wang Key Laboratory of Solidifi cation Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315000China Institute of Casting Research Montanuniversitat Leoben8700LeobenAustria

Ultrasonic cavitation radiates huge power in a small solidifying bulk,leading to significant grain refinement,purification and homogenization of the final alloys.Ultrasound vibration has mostly been used for treating the solidification of light metals,but it is difficult to directly introduce ultrasonic vibration into copper alloy due to the lack of proper sonotrode.In this work,we have used a Sialon ceramic sonotrode to propagate acoustic waves in a Cu-Cr alloy melt.Significant grain refinement and modification of primary Cr have been obtained.With the ultrasound vibration treatment,the mechanical properties of the as-cast Cu-Cr alloy have been improved.The wear resistance of the Cu-Cr alloy has also shown enhancement with respect to the untreated alloy.

关键词： Cu-Cr alloys Microstructure Ultrasonic vibration acoustic cavitation Solidification process

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Role of ultrasonic oscillation in chemical processes in microreactors:A mesoscale issue

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Particuology 2020年第1期18卷 88-99页

作者： Shuainan Zhao Chaoqun Yao Zhengya Dong Guangwen Chen Quan Yuan Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

The integration of microreactor and ultrasound represents an emerging area for process intensification and has attracted considerable attention in recent years.One of the most important meso-scientific issues in ultrasound techniques is acoustic cavitation,which plays a vital role in the macroscopic performance of an ultrasonic microreactor.In this review,we first briefly summarize the latest research on acoustic cavitation phenomena in microreactors.The effects of channel configuration,solvent properties,and ultrasound parameters are systematically reviewed.In addition,the role of acoustic cavitation in various chemical processes(e.g.,mixing,absorption,emulsification,and particle synthesis)is presented from a mesoscale perspective,which in turn provides guidance for ultrasound applications.A thorough under-standing of the ultrasound intensification mechanism will contribute to the future development of this promising technology.

关键词： Ultrasound Microreactor acoustic cavitation Mesoscale Process intensification

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超声波解吸柠檬酸盐溶液中二氧化硫的研究(英文)

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Chinese Journal of Chemical Engineering 2007年第4期15卷 486-491页

作者：薛娟琴孟令嫒沈彬彬杜士毅兰新哲 School of Metallurgical Engineering Xi'an University of Architecture and Technology School of Metallurgical Engineering Xi’an University of Architecture and Technology

Using a sonochemical reactor designed by the authors,the process of removing sulfur dioxide from cit- rate solution simulating the flue gas desulfurization was studied.The influence of ultrasonic frequency,ultrasonic power,reaction temperature,stirring speed,inert gases,initial concentration of sulfur dioxide and concentration of citrate on the efficiency of sulfur dioxide desorption,the stability of citrate solution and the concentration of sulfate radical was examined systematically.By comparing the desorption of sulfur dioxide with and without ultrasonifica- tion,it was concluded that(1)lower ultrasonic frequency results in a better degassing efficiency;(2)the use of ul- trasonification in desorbing sulfur dioxide from citrate solution improves the desorbing efficiency in some condi- tions,without changing the essence of chemical reactions;(3)sparging inert gas into the liquid can lower the vis- cosity of solution and the cavitating threshold,and raise the desorption efficiency.These results demonstrate a technical way for deep desorption of sulfur dioxide and provide the fundamental data for future industrial disposal of sulfur dioxide.

关键词： flue gas desulphurization desorption efficiency ultrasonic degassing citrate acoustic cavitation

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