Effect of inertial acoustic cavitation on antibiotic efficacy in biofilms

作     者：M.GHASEMI S.SIVALOGANATHAN M.GHASEMI;S.SIVALOGANATHAN

作者机构：Department of Applied MathematicsUniversity WaterlooWaterloo N2L 3G1Canada 

出 版 物：《Applied Mathematics and Mechanics(English Edition)》 (应用数学和力学（英文版）)

年 卷 期：2021年第42卷第10期

页      面：1397-1422页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 10[医学] 

基　　金：the Natural Science and Engineering Research Council of Canada (NSERC) with a Discovery Grant (No.PGPIN-04772-2014) 

主　　题：biofilm mechanical disruption mathematical model acoustic cavitation bubble collapse antibiotic 

摘      要：Bacterial biofilms can lead to chronic infections,increase tolerance to antibiotics and disinfectants,resistance to phagocytosis,and other components of the body’s immune *** formation is implicated in the persistence of staphylococcal infections and chronic Pseudomonas aeruginosa lung infections in cystic fibrosis(CF)patients(which can result from biofilm-growing mucoid strains).Conventional treatments utilize aggressive antibiotic prophylaxis/therapy to prevent/eliminate biofilms,followed by chronic suppressive ***,the use of enzymes to dissolve the biofilm matrix was investigated,in addition to quorum sensing inhibitors to increase biofilm susceptibility to ***,we propose a novel strategy,utilizing ultrasound-induced inertial cavitation,to increase antibiotic *** wall shear stress at the biofilm interface is calculated,and viscoplastic constitutive equations are used to examine the biofilm response to the mechanical *** simulations suggest that the maximum biofilm detachment occurs at high pressure/low frequency,and the mechanical disruption can affect the biochemical processes inside the biofilm resulting in vulnerability to antibiotics.