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Effect of inertial acoustic cavitation on antibiotic efficacy in biofilms

Applied Mathematics and Mechanics(English Edition) 2021年第10期42卷 1397-1422页

作者： M.GHAsEMI s.sivaloganathan Department of Applied Mathematics University WaterlooWaterloo N2L 3G1Canada

Bacterial biofilms can lead to chronic infections,increase tolerance to antibiotics and disinfectants,resistance to phagocytosis,and other components of the body’s immune *** formation is implicated in the persistence of staphylococcal infections and chronic Pseudomonas aeruginosa lung infections in cystic fibrosis(CF)patients(which can result from biofilm-growing mucoid strains).Conventional treatments utilize aggressive antibiotic prophylaxis/therapy to prevent/eliminate biofilms,followed by chronic suppressive ***,the use of enzymes to dissolve the biofilm matrix was investigated,in addition to quorum sensing inhibitors to increase biofilm susceptibility to ***,we propose a novel strategy,utilizing ultrasound-induced inertial cavitation,to increase antibiotic *** wall shear stress at the biofilm interface is calculated,and viscoplastic constitutive equations are used to examine the biofilm response to the mechanical *** simulations suggest that the maximum biofilm detachment occurs at high pressure/low frequency,and the mechanical disruption can affect the biochemical processes inside the biofilm resulting in vulnerability to antibiotics.

关键词： biofilm mechanical disruption mathematical model acoustic cavitation bubble collapse antibiotic

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Pea3 expression promotes the invasive and metastatic potential of colorectal carcinoma

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World Journal of Gastroenterology 2014年第46期20卷 17376-17387页

作者： Aruz Mesci samira Taeb Xiaoyong Huang Rishi Jairath Darshan sivaloganathan stanley K Liu Faculty of Medicine University of TorontoToronto M5S 1A8Canada sunnybrook Health sciences Centre Sunnybrook Research InstituteToronto M4N 3M5Canada Department of Medical Biophysics University of TorontoToronto M4N 3M5Canada Department of Radiation Oncology University of TorontoToronto M5S 3E2Canada

AIM: To investigate the function of Pea3 in colorectal carcinoma (CRC) invasion and metastatic potential.

关键词： Colorectal cancer Pea3 Epithelial-mesenchymal transition Liver metastasis

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Effect of Dilution of Treated Distillery Effluent (TDE) on soil Properties and Yield of sugarcane

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American Journal of Plant sciences 2013年第9期4卷 1811-1814页

作者： Previna sivaloganathan Baskar Murugaiyan saravanan Appavou Leninraja Dharmaraj Department of soil science and Agricultural Chemistry Anbil Dharmalingam Agricultural College and Research Institute Trichirapalli India.

sugarcane is one of the most important cash crops, which plays a pivotal role in India’s agricultural and industrial economy. The treated distillery effluent (TDE) being plant originated, contains all plant nutrients and organic matter. Therefore, it is being used as a cheap source of nutrients and organic manure in agriculture activities in soil besides improving soil physical properties. The experiment was conducted during August, 2010-2011 and 2011-2012 with CO 86032 in a randomized block design with six treatments and was replicated four times. The TDE was discharged @ 1.00, 0.50, 0.33, 0.25 and 0.20 lakh liters·ha-1 to get the dilutions of 1:10, 1:20, 1:30, 1:40 and 1:50 dilutions respectively. It was applied four times at 40 days interval starting from 45th day after planting. The fertilizers viz., N and P @ 75 percent of the recommended dose were applied and K was skipped. The results revealed that irrigation with TDE at 1:10 dilution resulted in higher yield of sugarcane. The TDE did not have any influence on quality parameters of sugarcane. The TDE application favourably influenced the available nutrients and organic carbon content in the soil. Besides, the present findings credibly proved that the TDE application not only enhanced the soil fertility status but also substituted for 25 percent of N and P and 100 percent of K fertilizers to sugarcane crop.

关键词： TDE Dilution sugarcane Yield soil Properties

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