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Antibody seropositivity and endemicity of chikungunya and zika viruses in Nigeria

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Animal Diseases 2023年第2期3卷 104-114页

作者： Peter Asaga Mac Philomena E.Airiohuodion Raman Velayudhan Shaistha Zubair Markos Tadele Jude,O.Aighobahi Chukwuma Anyaike Axel Kroeger Marcus Panning Institute of Virology University Medical FreiburgHermann Herder Str1179104 FreiburgGermany World Health Organization Special Programme for Research and Training in Tropical Diseases(TDR)Avenue Appia 201211 Geneva 27Switzerland World Health Organization WHO/NTD UnitAvenue Appia 201211 Geneva 27Switzerland Maldives National University BuruzuMaguMaleMaldives Ethiopian Institute Of Agricultural Research/EIAR Addis AbabaEthiopia Icon Clinical Research Heinrich‑Hertz Starsse 2663225 Langen HessenBerlinGermany Federal Ministry of Health National Tuberculosis and Leprosy ControlProgrammeAbujaNigeria Centre for Medicine and Society Faculty of MedicineUniversity of FreiburgFreiburgGermany

Mosquito-borne infections are of global health concern because of their rapid spread and upsurge,which creates a risk for *** virus(CHIKV),an arbovirus disease transmitted by Aedes aegypti or ***,and malaria,a parasitic disease transmitted by Anopheles gambiae,are prevalent in Nigeria and neighbouring countries,but their burden and possible coinfections are poorly *** this study,we investigated the antibody seropositivity and endemicity of chikungunya and zika viruses(ZIKV)in three regions of Nigeria.A cross-sectional serosurvey was conducted on 871 *** were collected from outpatients by simple random *** of the samples were performed using recomLine Tropical Fever for the presence of antibody serological marker IgG immunoblot with CHIKV VLP(virus like particle),ZIKV NS1 and ZIKV Equad according to manufacturers’instructions and malaria RDT for malaria *** was a significantly higher antibody seropositivity against CHIKV in the central region than in the northern and southern regions(69.5%,291/419),while ZIKV-seropositivity(22.4%,34/152)and CHIKV-ZIKV co-circulating antibody seropositivity(17.8%,27/152)were notably higher in the southern region than in the central and northern *** investigation revealed an unexpectedly high antibody seropositivity and concealed endemicity of CHIKV and ZIKV in three Nigerian *** seropositivity of detectable antibodies differed among the three geographical locations.

关键词： Chikungunya zika Cocirculation Seroprevalence Nigeria Endemicity Malaria

Immunological reactive rate to zika virus in canine sera:A report from a tropical area and concern on pet,zoonosis and reservoir host

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 199-200页

作者： Beuy Joob Viroj Wiwanitkit Saniation1 Medical Academic Center BangkokThailand Hainan Medical University HaikouHainanChina

This letter to editor discusses and describes zika virus IgG seropositivity rate in canine sera from endemic *** is the first world report and it raises an urgent concern on pet,zoonosis and reservoir host regarding Z... 详细信息

关键词： zika IhG Pet Zoonosis Reservoir host

Research progress of the causal link between zika virus and microcephaly

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Global Health Journal 2018年第4期2卷 11-18页

作者： Min Yan Rongsheng Luan Sichuan International Travel Healthcare Center No. 1 Tong Zi Lin North Road Chengdu 610041 China Department of Epidemiology and Health Statistics West China School of Public Health Sichuan University No. 17 Section 3 Ren Min Nan Road Chengdu 610041 China

zika virus (ZIKV) was an emergent flavivirus transmitted by Aedes genus mosquitoes and made an explosive outbreak in Latin America in 2015. A few months later, an obvious increase in the number of microcephaly neonates has been observed, which might be related to ZIKV infection during the mothers’ pregnancy. Since then, researchers in many countries and territories have been working on the causal link between ZIKV and microcephaly and have made a number of achievements. To summarize the most recent evidence and the contribution of Chinese researchers on this issue, and to provide perspectives and challenges for future studies, we reviewed the literature of both microcephaly and ZIKV. Based on previous research results, ZIKV has been preliminarily proved to be the direct cause of microcephaly in newborns and Chinese researchers have made many important discoveries in the pathogenesis of microcephaly. Even so, future researches should also further investigate the mechanism of ZIKVrelated microcephaly to advance the development of therapeutic and preventive strategies.

关键词： zika virus microcephaly mechanism

The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from zika virus infection

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Science Bulletin 2020年第5期65卷 402-409页

作者： Weihong Zhang Yongfen Xu Fanfan Zhao Marion Tarbe Shuru Zhou Weihong Wang Shengyuan Zhang Wei Zhang Qiuping Xu Lina Shi Feng Yuan Xinwen Lin Shuai Liu Jing Sun Jincun Zhao Yaling Yang Xiaozhen Liang Jin Zhong Gang Long Chengfeng Qin Qibin Leng Hong Tang State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China State Key Laboratory of Respiratory Diseases Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510095China Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China Department of Virology State Key Laboratory of Pathogen and BiosecurityBeijing Institute of Microbiology and EpidemiologyBeijing 100071China University of Chinese Academy of Sciences Beijing 100049China

zika virus(ZIKV)and Japanese encephalitis virus(JEV)are closely related flaviviruses,ZIKV circulates in the population that has been JEV vaccinated in Southeast Asian *** alerts that a pre-existing immunity to JEV would impact ZIKV infection and/or *** we showed that the preexisting immunity to JEV SA14-14-2 vaccination provided an ample protection against non-lethal or lethal dose of ZIKV infection in *** was in sharp contrast to the passive immunization of JEV antibodies,which failed to affect ZIKV infection or pathogenesis in mice,albeit these antibodies exhibited cross-reactivity and antibody dependent enhancement(ADE)of ZIKV infection in ***,we determined that JEV vaccine-elicited CD8+T cells were required to mediate the heterotypic protection of ZIKV infection,which cross-reacted to ZIKV E and NS5 antigens(E294-302and NS52839-2848).Adoptive transfer of these CD8+T cells could partially protect the mice from ZIKV ***,although short of epidemiological evidence,these results suggested that cross-reactive CD8+T cells activated by JEV vaccination could protect potential ZIKV infection in human populations.

关键词： Japanese encephalitis virus zika virus CD8+T Cross protection

zika-How fast does this virus mutate?

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Zoological Research 2016年第2期37卷 110-115页

作者： Ian S.LOGAN 22ParksideDrive ExmouthDevonUKEX84LB

The World Health Organization has declared the present zika virus epidemic to be a ＇Public Health Emergency of International Concern＇. The virus appears to have spread from Thailand to French Polynesia in 2013, and has since infected over a million people in the countries of South and Central America. In most cases the infection is mild and transient, but the virus does appear to be strongly neurotropic and the presumptive cause of both birth defects in fetuses and Guillain-Barr6 syndrome in some adults. In this paper, the techniques and utilities developed in the study of mitochondrial DNA were applied to the zika virus. As a result, it is possible to show in a simple manner how a phylogenetic tree may be constructed and how the mutation rate of the virus can be measured. The study showed the mutation rate to vary between 12 and 25 bases a year, in a viral genome of 10 272 bases. This rapid mutation rate will enable the geographic spread of the epidemic to be monitored easily and may also prove useful in assisting the identification of preventative measures that are working, and those that are not.

关键词： zika Virus Polyprotein Mutation rate Phylogenetic tree

Risk assessment and genomic characterization of zika virus in China and its surrounding areas

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Chinese Medical Journal 2019年第14期132卷 1645-1653页

作者： Rong-Fei Liu Zhen-Jian He Peng Mei Jia-Cheng Xi Xu-Dong Cao Li-Hong Yuan Jia-Hai Lu School of Public Health Sun Yat-sen UniversityGuangzhouGuangdong 510080China Key Laboratory of Tropical Disease Control(Sun Yat-sen University) Ministry of EducationGuangzhouGuangdong 510080China Department of Chemical and Biological Engineering University of OttawaOttawaOntarioCanada School of Life Sciences and Biopharmaceutics Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510006China One Health Center of Excellence for Research & Training Sun Yat-sen UniversityGuangzhouGuangdong 510080China

Background:zika virus (ZIKV) has emerged as a global pathogen causing significant public health *** has reported several imported cases where ZIKV were carried by travelers who frequently travel between China and ZIKV-endemic *** fully characterize the ZIKV strains isolated from the cases reported in China and assess the risk of ZIKV transmission in China,comprehensive phylogenetic and genetic analyses were performed both on all ZIKV sequences of China and on a group of scientifically selected ZIKV sequences reported in some of the top interested destinations for Chinese ***:ZIKV genomic sequences were retrieved from the National Center for Biotechnology Information database through stratified *** event detection,maximum likelihood (ML) phylogenetic analysis,molecular clock analysis,selection pressure analysis,and amino acid substitution analysis were used to reconstruct the epidemiology and molecular transmission of ***:The present study investigated 18 ZIKV sequences from China and 70 sequences from 16 selected *** events rarely happens in all ZIKV Asian *** genomes were generally undergone episodic positive selection (17 sites),and only one site was under pervasive positive *** ZIKV imported into China were Asian lineage and were assigned into two clusters:Venezuela-origin (cluster A) and Samoa-origin cluster (cluster B) with common ancestor from French *** time of most recent common ancestors of Cluster A dated to approximately 2013/11 (95% highest posterior density [HPD] 2013/06,2014/ 03) and cluster B dated to 2014/08 (95% HPD 2014/02,2015/01).Cluster B is more variable than Cluster A in comparison with other clusters,but no varied site of biological significance was *** strains in Southeast Asia countries are independent from strains in America ***:The genetic evolution of ZIKV is *** are two independent intro

关键词： zika virus China Phylogeny Genetic evolution Risk assessment

Preventions and Controls on Congenital Transmissions of zika: Mathematical Analysis

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Applied Mathematics 2017年第4期8卷 500-519页

作者： Nita H. Shah Zalak A. Patel Bijal M. Yeolekar Department of Mathematics Gujarat University Ahmedabad Gujarat India L. D. College of Engineering Ahmedabad Gujarat India

Vector-borne diseases threat lives of millions of people in many countries of the world. zika is one of the vector-borne diseases which initially spread by the bite of an infected Aedes species mosquito (Ae. aegypti and Ae. albopictus) and then it transmits vertically from a pregnant woman to her fetus or from an infected human to their sexual partners. The congenital transmission of zika virus (ZIKV) results in new born with microcephaly and other neurological abnormalities. The control of infected mosquitos is the best efficient way to control spread of ZIKV. Spraying insecticide is the safest and easiest way to control mosquitos, but sometimes it is cost worthy for long period of spraying. Controlled prevention from the vector bites can also help to control disease spread. To control congenital transmission and sexual transmission of ZIKV, preventions should be taken to reduce/stop pregnancy rate and safe heterosexual transmission among adults. Also, there is no specific treatment available for zika disease. Treatment is aimed at relieving symptoms with rest, fluids and medications. Controlled combinations of rest, fluids and medications will help to recover early. As costs are incorporated with spraying, preventions and treatment, our aim is to minimise the total cost associated by controlling spraying, preventions and treatment. To fulfil this purpose a mathematical model is developed with disease dynamics in nine compartments namely Susceptible human child, Susceptible human male, Susceptible human female, Infected human child, Infected human male, Infected human female, Recovered human, Susceptible vector and Infected vector including vertical transmission of zika disease. Numerical simulations have been carried out to optimise controls, and basic reproduction number and stability are calculated.

关键词： zika Vertical Transmission Dynamical System Control Stability

The global spread of zika virus:is public and media concern justified in regions currently unaffected?

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Infectious Diseases of Poverty 2016年第1期5卷 313-318页

作者： Narayan Gyawali Richard S.Bradbury Andrew W.Taylor-Robinson Infectious Diseases Research Group School of Medical&Applied SciencesCentral Queensland UniversityRockhampton 4702QLDAustralia

Background:zika virus,an Aedes mosquito-borne flavivirus,is fast becoming a worldwide public health concern following its suspected association with over 4000 recent cases of microcephaly among newborn infants in ***:Prior to its emergence in Latin America in 2015–2016,zika was known to exist at a relatively low prevalence in parts of Africa,Asia and the Pacific *** extension of its apparent global dispersion may be enabled by climate conditions suitable to support the population growth of *** and *** mosquitoes over an expanding geographical *** addition,increased globalisation continues to pose a risk for the spread of ***,suspicions of alternative modes of virus transmission(sexual and vertical),if proven,provide a platform for outbreaks in mosquito non-endemic regions as *** a vaccine or anti-viral therapy is not yet available,current means of disease prevention involve protection from mosquito bites,excluding pregnant females from travelling to zika-endemic territories,and practicing safe sex in those ***,in countries where zika is reported as endemic,caution is advised in planning to conceive a baby until such time as the apparent association between infection with the virus and microcephaly is either confirmed or *** question arises as to what advice is appropriate to give in more economically developed countries distant to the current epidemic and in which zika has not yet been ***:Despite understandable concern among the general public that has been fuelled by the media,in regions where zika is not present,such as North America,Europe and Australia,at this time any outbreak(initiated by an infected traveler returning from an endemic area)would very probably be contained *** Aedes *** very limited spatial dispersal,overlapping high population densities of mosquitoes and humans would be needed to sustain a focus of ***,as ***

关键词： zika Flavivirus Arbovirus Mosquito Aedes Transmission Vector control Diagnosis Treatment Epidemic

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zika Virus Screening in the Kenyan Olympic Team Attending the 2016 Olympic Games in Brazil

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Open Journal of Preventive Medicine 2018年第6期8卷 183-187页

作者： John N. Waitumbi Neha Buddhdev George Awinda Lucy Kanyara Zephania Irura Victor Ofula Limbaso Konongoi Rosemary Sang Basic Science Laboratory US Army Medical Research Directorate Kenya/Kenya Medical Research Institute Kisumu Kenya VHF Lab Kenya Medical Research Institute Nairobi Kenya

The 2016 Olympic Games happened at the time of heightened fears of zika virus (ZIKV) that was causing microcephaly in newborns in Brazil. To avert or track introduction of ZIKV in Kenya, the Ministry of Health developed a public health response that involved screening of the Kenyan contingent before and after traveling to Brazil. Of the 92 team members that were screened, all but one tested negative for ZIKV IgM and IgG. The sero-positive individual had high IgM serum titers before and after travel to Brazil. When tested for potential antibody cross-reactivity to other flaviviruses that have been reported in Kenya, the sample showed high IgM cross-reactivity to West Nile, Tick-Borne Encephalitis and Yellow Fever Virus. Our data support the low risk predictions of acquiring ZIKV that were made before the Games and will help inform risk assessments for personnel traveling to endemic regions under similar circumstances in the future.

关键词： zika Virus Screening