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youjing granules ameliorate spermatogenesis in rats through regulating the prolifereation of spermatogonial stem cells

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Chinese Journal of Natural Medicines 2022年第8期20卷 580-588页

作者： JIANG Xu-Ping SUN Yao-Xiang QIAO Bin ZHU Wen-jiao CHU Yu-Jiao SUN Miao-Miao ANG Ruije MA Tie-Liang ANG Zhi-An Department of Traditional Chinese Medicine the Affiliated Yixing Clinical School of Medical School of Yangzhou UniversityYixing 214200China Central Laboratory the Affiliated Yixing Hospital of Jiangsu UniversityYixing 214200China Department of Rehabilitation the People's Hospital of Daxinganling RegionDaxinganling 165000China School of Medicine School of Integrated Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210023China

Male infertility has evolved from a common reproductive system disease to a major social *** granule(YG)is a Chinese medicinal material used as a therapy method for tonifying the kidneys and removing dampness due to its pathogenic *** has been shown to regulate sperm quality in clinical trials,but the underlying mechanism is not fully *** present study was aimed to explore the protective effects and mechanism of action of YG on male reproductive system damage caused by methyl methane sulfonate(MMS).We first established an infertility model of rats through oral administration of MMS and then treated with *** determine the effect of YG,spermatogenesis,microvascular density,and secretory function of Leydig cells and Sertoli cells in rats were *** stem cells(SSCs)were co-cultured with mouse embryo fibroblast(MEF)cells as an in vitro cell model before exposure to serum containing ***,the proliferation and apoptosis of SSCs were *** indicated that YG increased the expression of self-renewal and proliferation-related molecules such as glial cell line derived neurotrophic factor(GDNF)and fibroblast growth factor-2(FGF2),and improved the quality of sperm and the proliferation of *** conclusion,YG may protect spermatogenetic function of rats through regulating the proliferation and self-renewal of SSCs.

关键词： Male infertility youjing granules Spermatogenesis Spermatogonial stem cells

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