Youjing granules ameliorate spermatogenesis in rats through regulating the prolifereation of spermatogonial stem cells

作     者：JIANG Xu-Ping SUN Yao-Xiang QIAO Bin ZHU Wen-jiao CHU Yu-Jiao SUN Miao-Miao ANG Ruije MA Tie-Liang ANG Zhi-An JIANG Xu-Ping;SUN Yao-Xiang;QIAO Bin;ZHU Wen-Jiao;CHU Yu-Jiao;SUN Miao-Miao;TANG Rui-Jie;MA Tie-Liang;TANG Zhi-An

作者机构：Department of Traditional Chinese Medicinethe Affiliated Yixing Clinical School of Medical School of Yangzhou UniversityYixing 214200China Central Laboratorythe Affiliated Yixing Hospital of Jiangsu UniversityYixing 214200China Department of Rehabilitationthe People's Hospital of Daxinganling RegionDaxinganling 165000China School of MedicineSchool of Integrated Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210023China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2022年第20卷第8期

页      面：580-588页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81774314) the Foundation of Clinical Science and Technology of Wuxi(No.Q202059) the Top Talent Support Program for Young and Middle-Aged People of Wuxi Health Committee(Nos.BJ2020105 and HB2020108) the Clinical Medical Science and Technology Development Foundation of Jiangsu University(No.JYL20180068) 

主　　题：Male infertility Youjing granules Spermatogenesis Spermatogonial stem cells 

摘      要：Male infertility has evolved from a common reproductive system disease to a major social *** granule(YG)is a Chinese medicinal material used as a therapy method for tonifying the kidneys and removing dampness due to its pathogenic *** has been shown to regulate sperm quality in clinical trials,but the underlying mechanism is not fully *** present study was aimed to explore the protective effects and mechanism of action of YG on male reproductive system damage caused by methyl methane sulfonate(MMS).We first established an infertility model of rats through oral administration of MMS and then treated with *** determine the effect of YG,spermatogenesis,microvascular density,and secretory function of Leydig cells and Sertoli cells in rats were *** stem cells(SSCs)were co-cultured with mouse embryo fibroblast(MEF)cells as an in vitro cell model before exposure to serum containing ***,the proliferation and apoptosis of SSCs were *** indicated that YG increased the expression of self-renewal and proliferation-related molecules such as glial cell line derived neurotrophic factor(GDNF)and fibroblast growth factor-2(FGF2),and improved the quality of sperm and the proliferation of *** conclusion,YG may protect spermatogenetic function of rats through regulating the proliferation and self-renewal of SSCs.