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yizhijiannao granule and a combination of its effective monomers,icariin and Panax notoginseng saponins,inhibit early PC12 cell apoptosis induced by beta-amyloid(25-35)

引用

Neural Regeneration Research 2012年第24期7卷 1845-1850页

作者： Ting Zhang Zhanwei Zhang Keli Dong Guangcheng Li Hong Zhu Department of Traditional Chinese Medicine Xiangya Third HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Neurosurgery First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

One of our previous studies showed that yizhijiannao granule,a compound Chinese medicine, effectively improved the clinical symptoms of Alzheimer’s *** the present study,we established a model of Alzheimer’s disease using beta-amyloid（25-35）in PC12 cells,and treated the cells with yizhijiannao granule and its four monomers,i.e.,icariin,catechin,Panax notoginseng saponins,and eleutheroside *** cytometry showed that yizhijiannao granule-containing serum, icariin,Panax notoginseng saponins,and icariin＋Panax notoginseng saponins were protective against beta-amyloid（25-35）-induced injury in PC12 *** in combination with Panax notoginseng saponins significantly inhibited early apoptosis of PC12 cells with beta-amyloid （25-35）-induced injury compared to icariin or Panax notoginseng saponins *** effects of icariin＋Panax notoginseng saponins were similar to the effects of yizhijiannao *** findings indicate that two of the effective monomers of yizhijiannao granule,icariin and Panax notoginseng saponins,can synergistically inhibit early apoptosis of PC12 cells induced by beta-amyloid（25-35）.

关键词： Alzheimer’s disease icariin Panax notoginseng Saponins yizhijiannao granule Chinese medicine monomer beta-amyloid protein PC12 cell Chinese medicine neural regeneration

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Treating Alzheimer's disease with yizhijiannao granules by regulating expression of multiple proteins in temporal lobe

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Neural Regeneration Research 2014年第13期9卷 1283-1287页

作者： Hong Zhu Liuyang Luo Sihang Hu Keli Dong Guangcheng Li Ting Zhang Department of Traditional Chinese Medicine Third Xiangya Hospital of Central South University Department of Emergency Bao-an District Hospital of Traditional Chinese Medicine

yizhijiannao granules have been shown to improve cognitive function in Alzheimer＇s disease patients. The present study sought to explore the mechanisms involved in the cognitive enhancing effects of yizhijiannao granule. Senescence-accelerated mouse prone 8 mice with learning and memory disorders were intragastrically treated with yizhijiannao granule for 8 weeks. Mice intragastrically treated with double distilled water for 8 weeks were considered as the control group. 2D gel electrophoresis was used to isolate total protein from the temporal lobe of senescence-accelerated mouse prone 8 mice, and differential protein spots were obtained by mass spectrometry. Thirty-seven differential protein spots were found in the temporal lobe area of both groups. Ten protein spots were identified： high mobility group box 1, dimethylarginine dimethylaminohydrolase-1, nenroglobin, hemoglobin beta adult major chain, peroxiredoxin-6, cofilin-1, flotiUin 1, peptidylprolyl isomerase A, voltage-dependent anion channel-2 and chaperonin containing TCP1, and subunit 2. Among other functions, these proteins are separately involved in the regulation of amyloid beta production, oxidative stress, neuroinflammation, regulation of tau phosphorylation, and regulation of neuronal apoptosis. Our results revealed that yizhijiannao granule can regulate the expression of various proteins in the temporal lobe of senescence-accelerated mouse prone 8 mice, and may be therapeutically beneficial for the treatment of Alzheimer＇s disease.

关键词： nerve regeneration traditional Chinese medicine neurodegeneration Alzheimer'sdisease yizhijiannao granule mass spectrometry cognition neural regeneration

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