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Effects of Combined Therapy of xuezhikang capsule(血脂康胶囊)and Valsartan on Hypertensive Left Ventricular Hypertrophy and Heart Rate Turbulence

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Chinese Journal of Integrative Medicine 2010年第2期16卷 114-118页

作者：龚春黄绍烈黄剑峰章志芳罗鸣赵宇江小杰 The Cardiovascular Department the First Affiliated Hospital of Nanchang University The Ultrasonic Department the First Affiliated Hospital of Nanchang University Fengcheng Municipal Hospital of Traditional Chinese Medicine The Dynamic ECG Department.the First Affiliated Hospital of Nanchang University The Cardiovascular Department the Fourth Affiliated Hospital of Nanchang University

Objective：To observe the effect of combined therapy with xuezhikang capsule（血脂康胶囊,XZK） and Valsartan on left ventricular hypertrophy（LVH） and heart rate turbulence（HRT） in hypertensive patients. Methods：Ninety primary hypertensive patients with LVH were randomly assigned to three *** treatment,including aspirin,β-blockers,calcium antagonists,*** administered to all ***, Valsartan（VS,80 mg once a day） was given to the 30 patients in the VS ***（in the same dosage） and XZK（600 mg,twice a day） were given to the 32 patients in the Chinese medicine（CM） group,while none was given to the 28 patients in the control *** therapeutic course lasted for 24 *** in left ventricular mass index（LVMI） measured by cardiac ultrasonic indices,HRT parameters,including the original heart rate（TO） and slope coefficient（TS）,systolic and diastolic blood pressures（SBP and DBP）,as well as blood cholesterol level（TC） were measured before and after ***：After treatment,TO and LVMI were lowered,while TS increased in both the VS group and the CM group（P〈0.01）,but changed insignificantly in the control *** differences between the CM group and the control group were shown in terms of TO,LVMI,SBP,DBP and TS（P〈0.01）;and between the CM group and the VS group in terms of TO,LVMI and TS（P〈0.01）.Moreover,HRT parameters showed an evident correlation with LVMI（r=0.519-0.635,P〈0.01）. Conclusion：Combined therapy with XZK and Valsartan can improve hypertensive LVH and HRT parameters, and lessen the damage on the autonomous nervous system.

关键词： heart rate turbulence left ventricular hypertrophy hypertension xuezhikang capsule Valsartan

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Effect of xuezhikang capsule(血脂康胶囊)on Serum Tumor Necrosis Factor-αand Interleukin-6 in Patients with Nonalcoholic Fatty Liver Disease and Hyperlipidemia

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Chinese Journal of Integrative Medicine 2010年第2期16卷 119-123页

作者：范小芬邓银泉叶蕾李友第陈玖卢雯雯李剑平 Department of Traditional Chinese Medicine The First Affiliated HospitalCollege of MedicineZhejiang University Department of Hepatology Zhejiang Hospital of Traditional Chinese MedicineHangzhou(310003)China

Objective：To evaluate the effect of xuezhikang capsule（血脂康胶囊） on the serum levels of inflammatory factors such as tumor necrosis factor-α（TNF-α） and interleukin-6（IL-6） in patients with nonalcoholic fatty liver disease（NAFLD） and hyperlipidemia,and to explore whether it has anti-inflammatory ***：A total of 84 patients were randomly assigned to two groups with stratified block randomization, the treatment group（42 cases） and the control group（42 cases）.They were treated with xuezhikang capsule and polyene phosphatidylcholine capsule for twenty-four weeks,*** changes in serum TNF-αand IL-6 were measured by enzyme linked immunosorbent assay before treatment and at the 12th and 24th week. Results：Compared with those before treatment,the serum levels of TNF-αand IL-6 significantly decreased in both groups after treatment（P〈0.01）.There was no significant change between the two groups for the treatments at different time points（P〉0.05） and between the two groups for treatments at the same time points （P〉0.05）.Conclusion：xuezhikang capsule can inhibit the serum inflammatory factor in patients with NAFLD and hyperlipidemia.

关键词： xuezhikang capsule nonalcoholic fatty liver disease hyperlipidemia tumor necrosis factor-α interleukin-6

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Summarization on Current Status of the Research on Clinical Application of xuezhikang capsule (血脂康胶囊)

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Chinese Journal of Integrated Traditional and Western Medicine 2006年第2期12卷 89-91页

作者：寇文鎔 Fuwai Hospital of Cardiovascular Diseases Chinese Academy of Medical Sciences Beijing (100037)

xuezhikang capsule （XZK,血脂康胶囊） is a blood lipid regulator made of special refined red yeast, and it was proved through lots of clinical practice in the 10 years, to have safe, stable and evident effect in regul... 详细信息

关键词： xuezhikang capsule Clinical Application Current Status clinical application clinical practice current status blood lipids 血脂康胶囊

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Effects of xuezhikang capsule (血脂康胶囊) on High Risk Population in Chinese Coronary Secondary Prevention Study (CCSPS) and the Enlightenment from It

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Chinese Journal of Integrated Traditional and Western Medicine 2006年第2期12卷 87-89页

作者：顼志敏 Fuwai Hospital of Cardiovascular Diseases Chinese Academy of Medical Sciences Beijing (100037)

Summery of CCSPS Trial and Its Sub-group Analysis Chinese coronary secondary prevention study （CCSPS）, one of the key items of the Ninth Five-year Plan of China, is a largescale multicenter, randomized, double-blinded and placebo controlled clinical trial. From May 1996 to Dec. 2003, 4 870 patients with definite history of myocardial infarction, aged 18- 75 years with their serum cholesterol levels ranging 4.40- 6.47 mmol/L （ 170- 250 mg/dl）,

关键词： xuezhikang capsule 血脂康胶囊 clinical trial

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Effects of xuezhikang capsule(血脂康胶囊) on Blood Lipids,Platelet Activation and Coagulation-Fibrinolysis Activity in Patients with Hyperlipidemia

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Chinese Journal of Integrated Traditional and Western Medicine 2004年第4期10卷 259-262页

作者：刘志高余细勇 Department of Cardiology Affiliated Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan (430077) Guangdong Provincial Institute of Cardiovascular Diseases Guangzhou

Objective: To investigate the effects of xuezhikang capsule (XZK,血脂康胶囊) on blood lipids level, platelet activation and coagulation-fibrinolysis activity in patients with hyerlipidemia. Methods: Seventy-six patients of hyperlipidemia were randomly divided into two groups, the XZK group (n=38) treated with XZK 600mg, taken two times per day and the Simvastatin (SIM) group (n = 38) treated with SIM 20mg per day, with the treatment lasting 8 weeks for both groups. Levels of fasting serum lipids, including total cholesterol (TC), triglyceride (TG), high and low density lipoprotein cholesterol (HDL-C and LDL-C), plasma GMP-140, fibrinogen (FIB), tissue plasminogen activator (t-PA), plasminogen activator inhibitor type-1 (PAI-) and prothrombin time (PT) were all measured before and 8 weeks after treatment. Data were compared before and after treatment and also compared with those measured in 20 healthy subjects of control. Results: Before treantment the levels of TC, TG and LDL-C were obviously higher and HDL-C level was significantly lower in hyperlipidemia patients than those in healthy subjects (P0.05), instead it showed obvious increase of HDL-C and decrease of TC and LDL-C after treatment (P<0.05 or P<0.01). Conclusion: XZK could inhibit platelet activity and improve coagulation-fibrinolysis function, besides its lipids lowering effect.

关键词： xuezhikang capsule Simvastatin hyperlipidemia platelet α-granule membrane glycopro-tein hyperlipidemia coagulation-fibrinolysis

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Anti-inflammatory Effects of xuezhikang capsule(血脂康胶囊)

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Chinese Journal of Integrated Traditional and Western Medicine 2006年第2期12卷 91-93页

作者：赵水平 Department of Cardiology The Second Xiangya Hospital Central South University Changsha (410011)

It has been proved that xuezhikang capsule （ XZK, 血脂康胶囊）, a Chinese red-yeast rice extract, contains multiple natural statins （8 monacolins） and other components, which could significantly reduce the total cholesterol （TO） and LDL- cholesterol concentrations in blood. Its benefits on coronary heart diseases have been studied in the recently conducted Chinese Coronary secondary prevention study （CCSPS）.

关键词： xuezhikang capsule 血脂康胶囊

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Protective effect of xuezhikang capsules in rats with acute myocardial ischemia reperfusion injury

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South China Journal of Cardiology 2012年第1期13卷 40-45页

作者：张雪娟宋立滕蕾平立风 Department of Cardiology Affiliated Hospital of Qingdao University Medical College Department of Anesthesiology Affiliated Hospital of Qingdao University Medical College Qingdao University Medical College

Background Recent researches have found that stains can improve acute myocardial ischemia reperfusion injury which is achieved by inhibiting inflammatory *** is extracted from red rice,a tailor-made Chinese crude *** component of xuezhikang that can inhibit blood-fat is *** Forty healthy SD rats （half male and half female,200 g or so） were randomly divided into four groups：A：normal control;B：sham operation;C：MIR group;D：xuezhikang *** acute myocardial ischemia reperfusion injury model was *** sizes,MYO,CK-MB,cTnI,IL-10 and IL-18 were detected after *** Compared with C and D group,in A and B group,infarct size were increased significantly （P 0.01）,the level of serum MYO,CK-MB,cTnI were increased significantly （P 0.01）,the level of IL-10 were decreased significantly （P 0.01） and IL-18,CRP were increased significantly （P 0.01）.Compared with C group,infarct size were decreased significantly （P 0.05）,the level of serum MYO,CK-MB and cTnI were increased significantly（P 0.05）,the level of IL-10 were increased significantly （P 0.05） and IL-18 were decreased significantly （P 0.05）.The level of IL-10 and IL-18 were no difference between A and B *** The application of xuezhikang capsules on rats before the operation of myocardial ischemia reperfusion can lessen inflammatory reaction and reduce infarct sizes and protect acute myocardial ischemia reperfusion.

关键词： xuezhikang capsule rats myocardium ischemia-reperfusion endothelial function

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