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Study on the action mechanism of wuling powder on treating osteoporosis based on network pharmacology

Chinese Journal of Natural Medicines 2021年第1期19卷 28-35页

作者： ZHOU Hao-Nan LI Hao-Yu XU Wen-Hua WEI Yan-Yi YU Rui-Xin WANG Wei CHEN Yuan-Ming Graduate School Guangxi University of Chinese MedicineNanning 530000China Graduate School Guangxi Medical UniversityNanning 530000China Department of Orthopedics the Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China

Osteoporosis is a health problem to cause global concern.A lot of methods have been used to prevent and treat osteoporosis,but there is still a lack of effective treatment for osteoporosis owing to limited understanding of its ***,the aim of this present study is to explore the underlying mechanism of wuling powder,a traditional Chinese medicine on treating *** this study,we firstly screened and identified the common targets between wuling powder and osteoporosis through the related databases,and then explored the relationships among these targets,wuling powder and osteoporosis by using Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG)and network ***,the molecular docking was performed by using systemsDock to evaluate the potential binding relationships between the active components of wuling powder and their related *** results showed that in total of 14 common targets including CREBBP,ADAM17,GOT1,GAPDH,USP8,ERBB2,EEF1 A1,MTOR,RAC1,ETS1,DDX58,GCK,EGF and S100 A8 were ***,ERBB2,MTOR and HIF-1 were the potential therapeutic targets for osteoporosis,and they were also the related targets for predicting active components in wuling *** together,we concluded that wuling powder might be used to treat osteoporosis through above these targets.

关键词： wuling powder Osteoporosis Network Pharmacology

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wuling powder alleviates depressive-like behavior by attenuating endoplasmic reticulum stress in the mouse hippocampus

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Journal of Chinese Pharmaceutical Sciences 2024年第9期33卷 783-794页

作者： Lu Feng Wei Huang Ji Zheng Dongmei Li Mingyang Wang Junya Liu Shujie Fan Chao Ji Nan Yang Yanyong Liu Department of Pharmacology Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

The response to endoplasmic reticulum(ER)stress has been noted in both human depression cases and depression models in *** powder,derived from the mycelium of the esteemed fungus Xylaria Nigripes(Kl.)Sacc,has demonstrated efficacy in alleviating depressive *** purpose of this research was to explore the antidepressant properties of wuling powder and its basic molecular effects,particularly regarding alterations in ER stress.A model of social defeat stress was created by introducing a mouse to the cage of an unfamiliar,hostile mouse for intervals of 5–10 min daily over a span of 10 ***,the mice received oral doses of wuling powder for 2 *** social approach-avoidance assay was employed to evaluate signs of depression-like ***,protein and gene expressions linked to ER stress triggered by social defeat were analyzed through Western blotting analysis and quantitative real-time *** behavioral tests indicated that wuling powder ameliorated behaviors associated with depression due to social defeat *** with wuling powder markedly reduced the increased levels of the 78-k Da glucose-regulated protein and protein disulfide isomerase caused by social defeat *** also diminished the expression of inositol-requiring enzyme 1α(IRE1α)and spliced X box-binding protein-1(s XBP1)at the protein and m RNA ***,wuling treatment notably decreased the levels of phosphorylated eukaryotic initiation factor 2 alpha kinase(P-e IF2α),activating transcription factor 4(ATF4)and C/EBP homologous protein(CHOP),simultaneously enhancing the ratio of B-cell lymphoma 2(Bcl-2)to Bcl-2-associated X protein(Bax).These results suggested that wuling powder could alleviate ER stress and inhibit cell apoptosis in the hippocampus by inhibiting protein translation and synthesis,thereby attenuating depressive-like behavior.

关键词： Depression wuling powder Endoplasmic reticulum stress Unfolded protein response

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Investigation on the mechanisms of wuling powder in treating myocardial ischemia-reperfusion injury based on network pharmacology and molecular docking with experiment verification

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South China Journal of Cardiology 2024年第3期25卷 179-192,F0003页

作者： LIU Mei-yu WANG Sheng Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510145China Department of Anesthesiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100013China

Background Myocardial ischemia-reperfusion injury is characterized by the inability of tissue and organ function to recover after the perfusion blood flow is restored followed by myocardial *** studies have shown that many Chinese herbal compounds can reduce myocardial ischemia-reperfusion injury,but the efficacy of wuling powder in treating myocardial ischemia-reperfusion injury has not been *** present study aimed to investigate the mechanism of wuling powder in treating myocardial ischemia-reperfusion injury by network pharmacology and molecular *** The active constituents of wuling powder were obtained by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and the related targets of active constituents of wuling powder were screened by the Swiss Target Prediction *** targets of myocardial ischemia-reperfusion injury were obtained by Gene Cards,Dis Ge NET and OMIM gene *** active compound-target network of wuling powder was constructed using Cytoscape *** drug prediction targets were mapped to the disease target set,and the intersection targets were *** Gene Ontology(GO)function and Kyoto Encyclopedia of Genes anf Genomes(KEGG)pathway enrichment analysis were performed on the intersection targets obtained by using String *** Dock Vina was used for molecular docking of core targets and the top 3 key active ingredients with degree *** Through screening,56 active ingredients and 116 targets of wuling powder were *** were 27 common targets of wuling powder and myocardial ischemia-reperfusion injury in Myocardial ischemia-reperfusion injury(MIRI).Protein-Protein Interaction(PPI)network analysis in this study showed that CASP3,PTGS2,CAT,JUN,ESR1,CASP8,CASP9 and RELA may be the key targets of wuling powder to exert the protective effect of *** functional analysis and KEGG pathway enrichment analysis showed that biologica

关键词： wuling powder Myocardial ischemia-reperfusion injury Network pharmacology Mechanism of action Molecular docking

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Efficacy and Safety of wuling powder and Western Medicine in Treatment of Hyperuricemia:A Meta-analysis of Clinical Trials

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Medicinal Plant 2021年第4期12卷 42-48页

作者： Qiushuang LI Zhe LI Qingyu XIE Kun ZHANG Guang RONG Pingxin HAN Biomedicine Department of Beijing City University Beijing 100094China Dongzhimen Hospital Beijing 100700China Chengdu Yilian Technology Co. Ltd.Chengdu 610041China

[Objectives]To compare the clinical efficacy and safety of wuling powder and conventional Western medicine for lowering uric acid in the treatment of hyperuricemia.[Methods]Databases such as CNKI,Wanfang Data,VIP Database,PubMed,Cochrane library and Embase,were retrieved,and comparative experiments of efficacy(serum uric acid level)and safety(incidence of adverse reactions)between wuling powder(used singly or combined with other prescriptions)and conventional Western medicine in the treatment of hyperuricemia were included,and effect size was pooled with Revman 5.3.[Results]A total of 11 articles,involving 817 patients,were included,and their research quality was evaluated to be *** terms of overall effect,wuling powder(used singly or combined with other prescriptions)was better than the control drug in reducing serum uric acid level,but the difference was insignificant[SMD=-0.37,95%CI(-0.90,0.16)].The heterogeneity between studies was *** incidence of adverse reactions in the experimental group was significantly lower than that in the control *** analysis shows that wuling powder combined with other prescriptions was better than the control drug in reducing serum uric acid level[SMD=-0.37,95%CI(-0.90,0.16),P=0.17],and the heterogeneity was reduced.[Conclusions]wuling powder combined with other prescriptions is better than conventional Western medicine in the treatment of hyperuricemia,and has better *** powder alone is not as effective as conventional Western *** is suggested that in clinical work,doctors may need to modify the prescription of wuling *** low quality of the literature supporting this conclusion suggests that this evidence should be interpreted with caution.

关键词： Hyperuricemia wuling powder Meta-analysis

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Research Hotspot and Trend Analysis of wuling powder Based on CiteSpace

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Agricultural Biotechnology 2023年第1期12卷 49-52页

作者： Luotong JING Yihan LI Ning LIANG Guangxi University of Chinese Medicine Nanning 530000China

[Objectives]This study was conducted to systematically present the research and development status of wuling powder over the years, and comprehensively analyze the hot spots and trends of wuling powder in the treatment of diseases, so as to provide reference for scholars in this field in the future. [Methods] China National Knowledge Network(CNKI) database was used as the literature retrieval source to search the literature related to wuling powder in the treatment of nephropathy, and then the data visualization analysis was carried out by using the software citespace.5.7.R2. [Results] Through accurate retrieval, a total of 204 effective literatures were included. It was found that domestic research on the treatment of nephropathy by wuling powder was on the rise. From the analysis of knowledge graph, it was concluded that after long-term research and development, a relatively concentrated core research group had been formed in China, which mainly focused on "wuling powder", "chronic kidney disease" and "diabetic nephropathy". [Conclusions] The research on the treatment of nephropathy by wuling powder shows a good development trend, and the research content is constantly enriched, and this research is still the current and future research hotspot.

关键词： wuling powder Nephropathy Citespace software Visual analysis Knowledge map

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Effects of wuling powder Mediating Notch Pathway on Mice with Nephrotic Syndrome

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Agricultural Biotechnology 2023年第6期12卷 25-29页

作者： Luotong JING Yihan LI Honglanxi LI Wenyan ZHANG Lin QIN Ning LIANG Guangxi University of Chinese Medicine Nanning 530000China

[Objectives]This study was conducted to investigate the renal protective effects of wuling powder on mice with nephrotic syndrome(NS)based on Notch pathway.[Methods]Sixty KM mice were randomly divided into normal group,model group,prednisone acetate positive group,high-dose wuling powder group,medium-dose wuling Power group and low-dose wuling Power group,with 10 mice in each *** days after prophylactic administration,a comprehensive nephropathy model was prepared by injecting 1 mg/ml doxorubicin hydrochloride solution(7.5 mg/kg)into the tail *** successful modeling,prednisone acetate and wuling SAN were given high,medium and low doses for intervention for 28 d,*** that,urinary protein and creatinine contents of mice in each group were detected,and pathological damage of renal tissue was observed by HE and Masson *** mRNA levels of Notch1,Jagged1 and Hes1 in mouse kidney tissues were detected by RT-PCR,and the expression levels of Notch1,Jagged1 and Hes1 proteins were detected by Western blot.[Results]wuling powder could effectively reduce the contents of urine protein(Pwuling powder groups could down-regulate the expressions of Notch1,Jagged1 and Hes1 mRNA in the kidney tissue of mice(Pwuling powder groups significantly decreased(Pwuling powder could protect the kidneys in mice with NS through Notch pathway.

关键词： wuling powder Nephrotic syndrome Mice Notch pathway

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