Efficacy and Safety of Wuling Powder and Western Medicine in Treatment of Hyperuricemia:A Meta-analysis of Clinical Trials
作者机构：Biomedicine Department of Beijing City UniversityBeijing 100094China Dongzhimen HospitalBeijing 100700China Chengdu Yilian Technology Co.Ltd.Chengdu 610041China
出 版 物：《Medicinal Plant》 (药用植物：英文版)
年 卷 期：2021年第12卷第4期
页 面：42-48页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by China Postdoctoral Science Foundation(2014M550133) Construction of Biostatistics Course Based on Mixed Teaching Platform(JYB20180724) Product Development and Cultural Dissemination of Traditional Chinese Medicine Preparations(20200107)
主 题：Hyperuricemia Wuling powder Meta-analysis
摘 要：[Objectives]To compare the clinical efficacy and safety of Wuling powder and conventional Western medicine for lowering uric acid in the treatment of hyperuricemia.[Methods]Databases such as CNKI,Wanfang Data,VIP Database,PubMed,Cochrane library and Embase,were retrieved,and comparative experiments of efficacy(serum uric acid level)and safety(incidence of adverse reactions)between Wuling powder(used singly or combined with other prescriptions)and conventional Western medicine in the treatment of hyperuricemia were included,and effect size was pooled with Revman 5.3.[Results]A total of 11 articles,involving 817 patients,were included,and their research quality was evaluated to be *** terms of overall effect,Wuling powder(used singly or combined with other prescriptions)was better than the control drug in reducing serum uric acid level,but the difference was insignificant[SMD=-0.37,95%CI(-0.90,0.16)].The heterogeneity between studies was *** incidence of adverse reactions in the experimental group was significantly lower than that in the control *** analysis shows that Wuling powder combined with other prescriptions was better than the control drug in reducing serum uric acid level[SMD=-0.37,95%CI(-0.90,0.16),P=0.17],and the heterogeneity was reduced.[Conclusions]Wuling powder combined with other prescriptions is better than conventional Western medicine in the treatment of hyperuricemia,and has better *** powder alone is not as effective as conventional Western *** is suggested that in clinical work,doctors may need to modify the prescription of Wuling *** low quality of the literature supporting this conclusion suggests that this evidence should be interpreted with caution.
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