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Gyejibokryeong-Hwan improves recovery of injured muscles in mouse model of muscle contusion

Journal of Traditional Chinese Medicine 2021年第3期41卷 406-413页

作者： Chi Ho Lee Jeong June Choi Joo Hye Sim Younmin Shin Seung-Joon Oh Ji-Hyang Gu Hyun Ju Ha Dong Hwi Jeon Eun-Jung Lee Min-Seok Oh Department of Korean Medicine Rehabilitation College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea Laboratory of Molecular Medicine College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea

OBJECTIVE: To investigate the effects of Gyejibokryeong-Hwan(Guizhifuling-wan, GBH) on muscle injury in a mouse model of muscle ***: C57/BL6 mouse biceps femoris muscles were injured using the drop-mass method and injured animals were treated orally with GBH(50,100, or 500 mg/kg) once a day for 7 d. Open field and treadmill running tests were performed to assess functional recovery from muscle injury. The production of pro-inflammatory cytokines was examined by enzyme-linked immunosorbent assay and Western blotting analysis. Expression of the muscle regeneration biomarkers, myoblast determination(Myo D), myogenic factor 5(Myf5), and smooth muscle actin(α-SMA), in the biceps femoris muscle was investigated at the protein and m RNA level by Western blotting and real time-PCR, respectively. Histological analysis was performed using hematoxylin and eosin staining. Finally, myosin heavy chain production was investigated in differentiated C2C12 myoblasts in the presence of ***: GBH treatment markedly improved locomotion and running behavior. GBH significantly inhibited the secretion of monocyte chemoattractant protein-1 into the bloodstream in muscle-contused animals. The levels of Myo D, Myf5, and α-SMA protein and m RNA were significantly up-regulated by GBH in injured muscle tissue. Histological studies suggested that GBH facilitated recovery from muscle damage. However, GBH did not induce the production of myosin heavy chain in ***: Overall, the present study suggested that GBH improves the recovery of the injured muscles in the mouse model of muscle contusion.

关键词： muscles wounds and injuries contusions regeneration muscle skeletal myogenic regulatory factor 5 Gyejibokryeong-Hwan

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Sodium Danshensu promotes the healing of stage 2 pressure injury wounds in ischemia/reperfusion injury rat models:possible regulation of apoptosis and inflammatory response

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Journal of Traditional Chinese Medicine 2021年第4期41卷 571-580页

作者： ZHANG Qiongzhi FU Tingting DAI Jianing ZHOU Zhinan SHEN Cuizhen School of Nursing Zhejiang Chinese Medical UniversityHangzhou 310053China

OBJECTIVE:To investigate the protective effect and possible mechanism of sodium Danshensu(SDSS)against pressure injury caused by ischemia/reperfusion(I/R)***:Sprague-Dawley rats were randomly divided into five groups of eight rats each:control group,model group,10 mg/kg SDSS-treated group,20 mg/kg SDSS-treated group,and 40 mg/kg SDSS-treated *** used two round ferrite magnetic plates of 15 mm diameter and 3 mm thickness to establish stage 2 pressure injury model *** rat was subjected to five cycles of ischemia and reperfusion to induce pressure *** cycle consisted of 2 h of ischemia and 0.5 h of reperfusion,which meant that each cycle included2 h of pressure and 0.5 h of pressure *** outline of the wound was delineated by butter paper and marker pen,and histopathological changes were observed by hematoxylin and eosin *** addition,the number of apoptotic cells and the activity of caspase-3 were assessed by terminal deoxynucleotidyl transferase-mediated nick end labeling and caspase-3 assay kits,*** expression of apoptosis-regulatory proteins and inflammatory mediators was investigated by enzyme-linked immunosorbent ***:Results showed that treatment with SDSS for 7 d after establishing the pressure injury model remarkably improved the healing rate of the *** also inhibited the levels of tumor necrosis factor-α,myeloperoxidase,and intercellular cell adhesion molecule-1;decreased the number of apoptotic cells;increased the ratio of B-cell lymphoma-2(Bcl-2)/Bcl-2-associated X(Bax);and regulated the expression and activity of ***:Our results suggest that SDSS exhibits a treatment efficacy for pressure injury caused by I/R injury possibly by inhibiting apoptosis and inflammatory response.

关键词： Danshensu apoptosis anti-inflammatory agents reperfusion injury pressure ulcer wounds and injuries

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Prevalence of musculoskeletal injuries and a proposal for neuromuscular training to prevent lower limb injuries in Brazilian Army soldiers:an observational study

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Military Medical Research 2019年第1期6卷 45-52页

作者： Michele Zukauskas de Andrade Gomes Carlos Eduardo Pinfildi Department of Human Movement Science Federal University of Sao Paulo(UNIFESP)Campus Baixada Santista Human Movement Science and Rehabilitation Department of Human Movement ScienceFederal University of Sao Paulo-Physical TherapyCampus Baixada Santista

Background: The activities carried out by soldiers in the army involve great physical demands and require intense trainings to perform combat-specific tasks. Musculoskeletal injury is a potential threat to the health and physical integrity of the soldier. This study aimed to evaluate the prevalence of lower limb musculoskeletal injuries among soldiers and to propose a training protocol to prevent the most frequent ***: This observational(cross-sectional) study recruited a sample of 103 soldiers who required medical attention,from a total 202 new battalion soldiers. The medical records(paper and online) had a form of running text. All data collected were recorded by the registered physicians of the battalion medical post. The records were analyzed by the following variables: medical diagnosis, injury site, mechanism, type of treatment, time loss, existence of previous injury,and recurring ***: A total of 112 musculoskeletal injuries were diagnosed in 71 soldiers, and other types of diseases/injuries were diagnosed in the other soldiers. Joint pain accounted for 55.4% of the diagnoses. The knee was the most affected site, while trauma and overload were the most common mechanisms of injury. Drug treatment was used most frequently, accounting for 58% of the cases. The majority of the sample obtained a temporary leave of absence for1 to 6 days or not at all. Previous injuries and recurrence were not presented as risk factors for injury. With the data received, a protocol for the prevention of injuries to the lower limbs was ***: This study indicated that the most frequent site of injury is the knee, and joint pain is the most common diagnosis. These results may support the necessity to develop a neuromuscular training protocol to prevent lower limb injuries, which we suggest to be applied in future studies.

关键词： Physical therapy wounds and injuries Primary prevention Lower extremity Proprioception Military personnel

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Efficacy of electroacupunture at Zusanli(ST36)on jumping-injured muscle based on transcriptome sequencing and genes analysis

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Journal of Traditional Chinese Medicine 2023年第2期43卷 322-328页

作者： HAN Rui CHANG Junzhao LIU Qianqian LIU Haitao LI Junwei School of Physical Education and Sport Henan UniversityKaifeng 475001China Kidney Department Xindu Hospital of Traditional Chinese MedicineChengdu 610500China Intensive Care Unit the Third Affiliated Hospital of Henan University of Chinese MedicineDiagnostics Facultythe Third School of Clinical Medicine of Henan University of Chinese MedicineZhengzhou 450053China

METHODS:In the present study,female SpragueDawley rats were randomly divided into four groups with 6 of each,including normal control group(NC),jumpinginduced muscle injury model group(JI),JI with electroacupuncture stimulation treatment group(EA),and JI with non-electroacupuncture stimulation group(NEA).Transmission electron microscopy,transcriptome sequencing and analysis,prediction of protein interaction networks,real-time polymerase chain reaction verification,and Western blotting were performed on the gastrocnemius muscle of ipsilateral lower ***:The structural repair of injured gastrocnemius myofibers following jumping training in EA rats was better than that of NEA rats.A total of 136 genes were differentially expressed in EA rats relative to JI rats,with 55 genes upregulated and 81 genes *** to results of transcriptome analysis,and prediction of protein mutual interaction by the online STRING database,Heat shock protein beta-7(Hspb7)and myozenin2(Myoz2)genes were *** of Hspb7 and Myoz2 mRNAs were increased in EA rats relative to JI rats(P<0.05).The expression of Hspb7 protein was upregulated in EA rats relative to that in NC,JI,and NEA rats(P<0.01,<0.05,and<0.05,respectively).The expression of Myoz2 protein was upregulated in EA rats relative to that in NC and JI rats(both P<0.01,respectively).CONCLUSIONS:The present results suggest that electroacupuncture stimulation at Zusanli(ST36)could improve muscle healing following jumping-induced muscle injury,owing to the upregulation of Hspb7 and Myoz2 proteins.

关键词： electroacupuncture stimulation skeletal muscle wounds and injuries gene expression profiling sequence analysis Hspb7 Myoz2

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Acute kidney injury in severely injured patients admitted to the Intensive Care Unit

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Military Medical Research 2021年第2期8卷 141-147页

作者： Alberto F.García Ramiro Manzano-Nunez Juan G.Bayona Maria P.Naranjo Dary Neicce Villa Manuel Moreno Sebastian Ossa Juan M.Martinez Nathalia Martinez Juan C.Puyana Division of Trauma and Acute Care Surgery Department of SurgeryFundación Valle del LiliCaliColombia Clinical Research Center Fundación Valle del LiliCaliColombia Escuela de Medicina Ciencias de la SaludUniversidad del RosarioCarrera 98#18-49760001BogotaColombia Méderi Hospital Universitario Mayor Colombia School of Medicine Universidad ICESI(ICESI University)CaliColombia Department of Surgery University of PittsburghPittsburghPAUSA

Background:Our objective was to identify possible associations between clinical and laboratory variables and the risk of developing acute kidney injury(AKI)in severely injured patients admitted to the Intensive Care Unit(ICU)for whom creatine kinase(CK)levels were ***:For this retrospective observational study,we analyzed adult trauma patients admitted to the ICU from 2011 to 2015 at Fundación Valle del Lili(FVL)University *** primary outcome was the incidence of *** regression analysis was used to assess risk factors for this ***:A total of 315 patients were *** trauma mechanisms were blunt(n=130),penetrating(n=66)and blast(n=44)*** median[interquartile range,(IQR)of injury severity score(ISS)was 21(16–29).AKI developed in 75 patients(23.8%).Multivariate regression analysis revealed that the thoracic abbreviated injury scale(AIS)value(median(IQR)in the AKI group:3(0–4)],Acute Physiology and Chronic Health Evaluation(APACHE Ⅱ)score[median(IQR)in the AKI group:18(10–27)],CK greater than 5000 U/L,lactic acid concentration at admission,and dobutamine administration were independently associated with ***:We found that age,APACHE Ⅱ score,thoracic trauma,lactic acidosis,and dobutamine administration were independently associated with *** surgeons need to be aware of the increased odds of AKI if one of these factors is identified during the evaluation and treatment of injured patients.

关键词： Rhabdomyolysis wounds and injuries Acute kidney injury Critical care Trauma

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Analysis of two naval pilots’ ejection injuries: Two case reports

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World Journal of Clinical Cases 2022年第24期10卷 8667-8672页

作者： Jia Zeng Xiao-Peng Liu Jia-Cheng Yi Xiang Lu Dan-Dan Liu Yan-Qing Jiang Yan-Bing Liu Jian-Quan Tian Department of Aviation Disease Naval Medical Center of PLAShanghai 200052China Department of Psychology Naval Medical Center of PLAShanghai 200052China Department of Clinical Medicine School of Basic MedicineHebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina

BACKGROUND Recently,two naval pilots in a two-seat trainer jet were forced to eject urgently due to sudden mechanical failure during night-time *** were both successfully rescued and sent to the hospital for emergency *** this study,we investigate their ejection injuries and recovery *** SUMMARY We analyzed the clinical data of the traumatic condition and recovery process from ejection injuries of two pilots who ejected from a failed trainer jet and *** being successfully rescued and sent to the hospital,they were diagnosed with multiple ejection injuries,including eye trauma,limb bone and joint injury,rib and spine injury,and so *** cases underwent fluid replacement,acid suppression,nutritional support,hemostasis,bone metabolism improvement,phlegm elimination,psychological measurement,blood circulation promotion and detumescence,physical therapy,and external fixation with braces for 1 mo before being discharged from *** then recuperated in a sanatorium for 2 mo,and the related laboratory tests and supplementary examinations show that they recovered from all the above *** successfully passing the psychological test and physical examination,they returned to flight duty 3 mo after *** The causes and conditions of ejection injury in the pilots were very *** they finally recovered quickly and were released,it also serves as a reminder that attention should be paid to pilots’ejection and parachute training in order to significantly reduce ejection injury and improve the ejection success *** addition,air defense support personnel should strengthen search and rescue and on-site emergency measures,and locate and rescue pilots in distress as early as possible to reduce subsequent injuries.

关键词： Aerospace medicine Pilots Aviation accidents wounds and injuries Case report

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Antiphospholipid syndrome with renal and splenic infarction after blunt trauma:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9404-9410页

作者： Na-A Lee Eui-Sung Jeong Hyun-Seok Jang Yun-Chul Park Ji-Hyoun Kang Jung-Chul Kim Young-Goun Jo Division of Trauma Department of SurgeryChonnam National University Medical School and HospitalGwangju 61469South Korea Division of Rheumatology Department of Internal MedicineChonnam National University Medical School and HospitalGwangju 61469South Korea

BACKGROUND In trauma patients,bleeding is an immediate major *** the same time,there are few cases of acute vascular occlusion after blunt trauma,and it is unclear what assessment and diagnosis should be considered for these ***,we describe a patient diagnosed with antiphospholipid syndrome after a hypercoagulable workup for acute renal and splenic vascular occlusion due to blunt *** SUMMARY A 20-year-old man was admitted to the emergency department with abdominal pain after hitting a tree while riding a sled 10 h *** had no medical *** investigations revealed occlusion of the left renal artery with global infarction of the left kidney and occlusion of branches of the splenic artery with infarction of the central portion of the *** revascularization of the left renal artery occlusion through percutaneous transluminal angioplasty failed due to difficulty in passing the wire through the total *** the presence of acute multivascular occlusions in a young man with low cardiovascular risk,additional laboratory tests were performed to evaluate *** results suggested a high possibility of antiphospholipid *** with a subcutaneous injection of enoxaparin was started and changed to oral warfarin after two *** diagnosis was confirmed,and he continued to visit the rheumatology outpatient clinic while taking *** A hypercoagulable workup can be considered in trauma patients with acute multivascular occlusion,especially in young patients with low cardiovascular risk.

关键词： wounds and injuries wounds Nonpenetrating Antiphospholipid syndrome Renal artery obstruction Splenic infarction Case reports

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Comparison of epidemiologic features between upper and lower limb injuries and risk factors for intensive care unit admission in a university hospital affiliated with the National Trauma Registry of Iran

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Chinese Journal of Traumatology 2024年第6期27卷 389-394页

作者： Pouya Mahdavi Sharif Mohsen Merati Vali Baigi Mohammadreza Zafarghandi Vafa Rahimi-Movaghar Moein Khormali Marjan Laal Payman Salamati Sina Trauma and Surgery Research Center Tehran University of Medical SciencesTehranIran Department of Epidemiology and Biostatistics School of Public HealthTehran University of Medical SciencesTehranIran

Purpose:Upper extremity injuries(UEIs)and lower extremity injuries(LEIs)constitute a considerable component of ***,their epidemiologic differences and short-term in-hospital outcomes are not fully *** study aims to compare such discrepancies in a large-scale ***:In this retrospective study,all patients with UEIs and/or LEIs hospitalized from 24th July 2016 to 16th May 2020 in Sina Hospital,Tehran,Iran,and registered at the National Trauma Registry of Iran were enrolled in the *** demographic and clinical characteristics were extracted from the National Trauma Registry of Iran *** were grouped into either UEI or *** those with concomitant UEIs and LEIs,the more severe one based on the abbreviated injury scale was defined as the principal *** addition,cases with the abbreviated injury scale>3 for both UEI and LEI or concomitant injuries to body areas other than the limbs were *** samplest-test,Mann-WhitneyU test,Chi-square test,quintile regression models,and logistic regression models with"margins"command were used for statistical analyses,as ***:In this research,3170 eligible cases were *** the LEI group,there was a much higher proportion of male patients(86.7%vs.82.0%)and higher mean age(years,42.9vs.35.3)compared to the UEI group(bothp<0.001).Patients with an injury severity score(ISS)of 9-15 were outnumbered in the LEI group(22.9%vs.1.6%,p<0.001),while the proportion of those with an ISS<9 was higher in the UEI group(98.1%vs.76.8%,p<0.001).The multiple logistic regression model showed a statistically significant association between intensive care unit(ICU)admission and ISS(odds ratio(OR)=4.01 for ISS ***<9,95%confidence interval(CI)):3.01-5.35;OR=17.65 for ISS≥***<9,95%CI:4.03-77.27),age(OR=1.02,95%CI:1.01-1.03),cause of injury(OR=0.27 for blunt *** traffic crash,95%CI:0.08-0.90;OR=0.49 for cut/stab *** traffic crash,9

关键词： wounds and injuries Lower extremity Upper extremity Intensive care unit Length of hospital stay

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Effect of environment on extremely severe road traffic crashes: retrospective epidemic analysis during 2000-2001

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Chinese Journal of Traumatology 2004年第6期7卷 323-329页

作者：覃华丽赵新才周继红邱俊杨在亮蒋志泉朱秉忠 Institute for Traffic Medicine Research Institute of Surgery Daping Hospital Third Military Medical University Chongqing 400042 China Traffic Administration Bureau of Chongqing 400042 China Traffic Administration Bureau of Chongqing 400042 ChinaA1.TrafficAdministrationBureauofMinistryofPublicSecurity.StatisticdataofroadtrafficcrashesinChina(2001).Beijing:MinistryofPublicSecurity2001.

Objective: To make an epidemiological analysis of the effect of environment on extremely severe road traffic crashes (RTCs). Methods: Epidemiologic data of extremely severe RTCs associated with environmental factors, including weather, topography, road conditions and other traffic conditions in China's Mainland during 2000-2001, were collected and analyzed. Results: (1) During 2000-2001, there were (3 365) extremely severe RTCs with (13 666) deaths, (12 204) injuries and a direct economical loss of 136 million RMB. (2) Most extremely severe RTCs occurred in fine weather days and in the daytime. The high occurrence sites were plain areas, horizontal and straight roads, Grade B and C roads, ordinary road segment, and asphalt, smooth and mixed roads. (3) Compared with other RTCs, extremely severe RTCs were more likely to happen under following conditions: on cloudy, snowing, misty and blustering days; in hill and mountainous areas; on crooked and sloping roads; on freeway, Grade A, B, and C roads; mixed roads; ordinary, bridge, narrow and transitional roads; sand and dirt-roads; without traffic control measures; night without lighting. (4) Extremely severe RTCs of mountainous area or crooked and sloping roads were most severe in terms of deaths and injures per crash. Conclusions: Extremely severe RTCs are closely related with environmental factors. Rational road programming, enhancing road establishment and improving road conditions are probably effective measures to reduce the road traffic injuries.

关键词： Accidents, Traffic Environment Epidemiology wounds and injuries China

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Clinical retrospective and comparative study on diaphragm injuries in 46 cases

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Chinese Journal of Traumatology 2001年第3期4卷 131-134页

作者：石应康武忠伍伫万亚红方强 Department of Thoracic and Cardiovascular Surgery The First Affiliated Hospital West China University of Medical Sciences Chengdu 610041 China.

Objective: To explore a way of guiding diagnosis and treatment of blunt and penetrating diaphragm injuries. Methods: According to injury violence, 46 chest trauma patients with diaphragm rupture were divided into two groups: a blunt injury group and a penetrating injury group. The injury condition and trauma scores between the two groups were compared and analyzed. Results: The incidence of blunt diaphragm injuries was lower than that of penetrating injuries ( 1.78 % vs 8.53 %, Pinjuries. Penetrating injuries developed more quickly than blunt injuries, and resulted in hemorrhagic shock in the early period. Trauma scores showed that there was no significant difference in the Revised Trauma Score (RTS), the Injury Severity Score (ISS) and thoracic Abbreviated Injury Scale (AIS) between the two groups (P> 0.05 ), but the blunt injury group had lower Glasgow Coma Scale (GCS) and abdominal AIS than the penetrating group (Pinjuries have different clinical characteristics. So they should be dealt with differently to reduce the incidence of complication and improve prognosis.

关键词： wounds, nonpenetrating wounds and injuries Diaphragm

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