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Challenges and innovations in treating chronic and acute wound infections:from basic science to clinical practice

Burns & Trauma 2022年第1期10卷 513-528页

作者： Xiaotong Ding Qinghan Tang Zeyu Xu Ye Xu Hao Zhang Dongfeng Zheng Shuqin Wang Qian Tan Joanneke Maitz Peter K.Maitz Shaoping Yin Yiwei Wang Jun Chen School of Pharmacy Jiangsu Provincial Engineering Research Center of Traditional Chinese Medicine External Medication Development and ApplicationNanjing University of Chinese MedicineNanjing 210023People’s Republic of China Department of Burns and Plastic Surgery The affiliated Drum TowHospital of Nanjing University of Chinese MedicineNanjing 210008People’s Republic of China Burns Injury and Reconstructive Surgery Research ANZAC Research InstituteUniversity of SydneySydneyAustralia2137 Burns Unit Concord Repatriation General HospitalConcordAustralia 2137

Acute and chronic wound infection has become a major worldwide healthcare burden leading to significantly high morbidity and *** underlying mechanism of infections has been widely investigated by scientist,while standard wound management is routinely been used in general ***,strategies for the diagnosis and treatment of wound infections remain a great challenge due to the occurrence of biofilm colonization,delayed healing and drug *** the present review,we summarize the common microorganisms found in acute and chronic wound infections and discuss the challenges from the aspects of clinical diagnosis,non-surgical methods and surgical ***,we highlight emerging innovations in the development of antimicrobial peptides,phages,controlled drug delivery,wound dressing materials and herbal medicine,and find that sensitive diagnostics,combined treatment and skin microbiome regulation could be future directions in the treatment of wound infection.

关键词： wound infections Skin microbiome Diagnosis Antimicrobial wound dressings Herbal medicine Hydrogels Antimicrobial peptides Phages Drug delivery

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Silver nanoparticles-decorated and mesoporous silica coated single-walled carbon nanotubes with an enhanced antibacterial activity for killing drug-resistant bacteria

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Nano Research 2020年第2期13卷 389-400页

作者： Yu Zhu Jia Xu Yanmao Wang Cang Chen Hongchen Gu Yimin Chai Yao Wang Shanghai Jiao Tong University Affiliated Sixth Peoples Hospital School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China

The mounting threat of antibiotic-resistant bacterial infections has made it imperative to develop innovative antibacterial *** we propose a novel antibacterial nanoplatform of silver nanoparticles-decorated and mesoporous silica coated single-walled carbon nanotubes constructed via a N-[3-(trimethoxysiltyl)propyl]ethylene diamine(TSD)-mediated method(SWCNTs@mSiO2-TSD@Ag).In this system,the outer mesoporous silica shells are able to improve the dispersibility of SWCNTs,which will increase their contact area with bacteria cell ***,the large number of mesopores in silica layers act as microreactors for in situ synthesis of Ag NPs with controlled small size and uniform distribution,which induces an enhanced antibacterial *** with TSD modified mesoporous silica coated single-walled carbon nanotubes(SWCNTs@mSiO2-TSD)and commercialAg NPs,this combination nanosystem of SWCNTs@mSiO2-TSD@Ag exhibits much stronger antibacterial performance against multi-drug-resistant bacteria Escherichia coli(***)and Staphylococcus aureus(***)in vitro through damaging the bacterial cell membranes and a fast release of silver ***,the in vivo rat skin infection model verifies that SWCNTS@mSiO2-TSD@Ag have remarkably improved abilities of bacterial clearance,wound healing promoting as well as outstanding ***,this novel nanoplatform indicates promising potentials as a safe and powerful tool for the treatment of clinical drug-resistant infections.

关键词： silver nanoparticles single-walled carbon nanotubes drug-resistant bacteria enhanced antibacterial activity wound infections

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