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Fatigue in patients with inflammatory bowel disease in Eastern China

World Journal of Gastroenterology 2021年第11期27卷 1076-1089页

作者： Shan-Shan Gong Yi-Hong Fan Bin Lv Mie-Qing Zhang Yi Xu Jing Zhao Department of Gastroenterology The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Fatigue is a very common but relatively neglected problem in patients with inflammatory bowel disease(IBD).The prevalence rate of IBD in China is the highest in Asia,but there is little research on fatigue in patients with *** the relationship between fatigue and quality of life(QoL)nor the relationship between fatigue and work productivity(WP)in Chinese IBD patients has been *** To investigate the prevalence of fatigue related to IBD in Eastern China,to identify the risk factors associated with fatigue,to assess the impact of fatigue on QoL,and to evaluate the relationship between fatigue and *** A cross-sectional study was conducted in a Regional Tertiary IBD Diagnostic and Treatment Center in Eastern *** data of patients were collected,and disease activity was *** samples were analyzed to assess anemia,albumin,and *** was assessed using the multidimensional fatigue *** and WP were measured using the short inflammatory bowel disease questionnaire and the work productivity and activity impairment general health questionnaire,*** patients also completed assessments of depression(Patient Health Questionnaire-9)and anxiety(Generalized Anxiety Disorder 7-item Scale).RESULTS A total of 311 IBD patients,comprising 168 Crohn's disease patients and 143 ulcerative colitis patients,were *** prevalence of fatigue in patients with IBD was 60.77%.In a univariate logistic regression analysis,factors such as disease activity,depression,anxiety,anemia,and IBD-related surgery were individually related to a significantly increased risk of fatigue in IBD *** logistic regression analysis indicated that depression[odds ratio(OR)=8.078,95%confidence interval(CI):4.113-15.865],anxiety(OR=2.373,95%CI:1.100-5.119),anemia(OR=2.498,95%CI:1.290-4.834),and IBD-related surgery(OR=2.035,95%CI:1.084-3.819)were related to fatigue in IBD *** was a negative correlat

关键词： Inflammatory bowel disease Fatigue Quality of life work productivity Risk factors Eastern China

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Golimumab in real-world practice in patients with ulcerative colitis:Twelve-month results

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World Journal of Gastroenterology 2020年第21期26卷 2852-2863页

作者： Niels Teich Harald Grümmer Eric Jorgensen Thomas Liceni Frank Holtkamp-Endemann Tim Fischer Susanne Hohenberger Internistische Gemeinschaftspraxis für Verdauungs-und Stoffwechselkrankheiten Leipzig und Schkeuditz Leipzig 04105Germany Praxis für Innere Medizin/Gastroenterologie Potsdam 14471Germany Magen-Darm-Zentrum Remscheid Remscheid 42859Germany MVZ für Gastroenterologie am Bayerischen Platz Berlin 10825Germany Gastroenterologische Gemeinschaftspraxis am Germania-Campus Münster 48159Germany Medical Affairs MSD Sharp and Dohme GmbHHaar 85540Germany

BACKGROUND The introduction of biologics has revolutionized the management of the chronic inflammatory bowel disease,ulcerative colitis(UC),with many patients experiencing significant improvements not only in their symptoms but in other outcomes relevant to individuals and society as a *** Germany,there are no prospective data>3 mo that assess the work productivity,daily activities and quality of life(QoL)of patients with moderate-to-severe UC treated with *** To assess change in work productivity,capacity for daily activities and QoL in UC patients treated with golimumab in *** The validated work productivity Activity Impairment(WPAI)Questionnaire was used to analyze the change in work productivity,the capacity for daily activities after three months(primary endpoint)and disease specific and health related QoL(HRQoL)up to 1 year(secondary endpoints).The changes in work productivity and activity impairment were evaluated every three months until month twelve compared to ***-specific and health-related QoL were assessed with the inflammatory bowel disease questionnaire and with the short-form 12 health survey questionnaire(SF-12).RESULTS This prospective non-interventional study included 287 *** analysis population was comprised of 282 patients who had completed at least two *** baseline,61%of patients had moderate UC and 18%had severe ***,75%of patients worked full-time or part-time at baseline.A total of 212 patients who were employed at the start of the study(employed population)were evaluated for the primary *** significantly reduced all WPAI sub-scores compared to baseline after three,six,nine and twelve months after the start of treatment(P<0.0001).In addition,disease-specific QoL and HRQoL,as measured by the SF-12 questionnaire,improved significantly with golimumab at all evaluation times(P<0.0001 in each case vs baseline).CONCLUSION Treatment of moderate-to-severe UC with golimum

关键词： Ulcerative colitis Quality of life work productivity Non-interventional study Golimumab work productivity Activity Impairment(WPAI)Questionnaire

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Benefit Evaluation Approach of Consumer Side Energy Management Systems Focusing on Enterprise productivity

Benefit Evaluation Approach of Consumer Side Energy Manageme...

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作者： Ken Kuroda Hideki Magori Tomiyasu Ichimura Ryuichi Yokoyama Waseda University Fujitsu Limited

Energy management systems(EMSs) for electricity consumers which manage energy consumption and control some energy consuming equipment in consumer side are expected to be one of effective measures for optimized energy supply and utilization. On the other hand, it is difficult to clarify the benefit of EMS installation, because EMS does not reduce energy consumption only with its installation but improvement or optimization of energy usage in consumer side should be necessary. In addition, whereas advantages of EMS installation such as energy cost and CO2 emission reduction have been considered, negative(trade-off) factors of energy saving have not been discussed enough. This paper proposes a benefit evaluation approach of EMS and the EMS installation impact on enterprise productivity is considered. Also, simulations using Monte Carlo method are conducted and their results are discussed and evaluated.

关键词： Demand control energy management system Monte Carlo method work productivity

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