Fatigue in patients with inflammatory bowel disease in Eastern China

作     者：Shan-Shan Gong Yi-Hong Fan Bin Lv Mie-Qing Zhang Yi Xu Jing Zhao 

作者机构：Department of GastroenterologyThe Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310000Zhejiang ProvinceChina Department of GastroenterologyThe First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2021年第27卷第11期

页      面：1076-1089页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：The National Natural Science Foundation of China,No.81473506 and No.81470814 Zhejiang TCM Science and Technology Project,No.2021ZA057,No.2019ZA056,and No.2018ZB046 

主　　题：Inflammatory bowel disease Fatigue Quality of life Work productivity Risk factors Eastern China 

摘      要：BACKGROUND Fatigue is a very common but relatively neglected problem in patients with inflammatory bowel disease(IBD).The prevalence rate of IBD in China is the highest in Asia,but there is little research on fatigue in patients with *** the relationship between fatigue and quality of life(QoL)nor the relationship between fatigue and work productivity(WP)in Chinese IBD patients has been *** To investigate the prevalence of fatigue related to IBD in Eastern China,to identify the risk factors associated with fatigue,to assess the impact of fatigue on QoL,and to evaluate the relationship between fatigue and *** A cross-sectional study was conducted in a Regional Tertiary IBD Diagnostic and Treatment Center in Eastern *** data of patients were collected,and disease activity was *** samples were analyzed to assess anemia,albumin,and *** was assessed using the multidimensional fatigue *** and WP were measured using the short inflammatory bowel disease questionnaire and the work productivity and activity impairment general health questionnaire,*** patients also completed assessments of depression(Patient Health Questionnaire-9)and anxiety(Generalized Anxiety Disorder 7-item Scale).RESULTS A total of 311 IBD patients,comprising 168 Crohn s disease patients and 143 ulcerative colitis patients,were *** prevalence of fatigue in patients with IBD was 60.77%.In a univariate logistic regression analysis,factors such as disease activity,depression,anxiety,anemia,and IBD-related surgery were individually related to a significantly increased risk of fatigue in IBD *** logistic regression analysis indicated that depression[odds ratio(OR)=8.078,95%confidence interval(CI):4.113-15.865],anxiety(OR=2.373,95%CI:1.100-5.119),anemia(OR=2.498,95%CI:1.290-4.834),and IBD-related surgery(OR=2.035,95%CI:1.084-3.819)were related to fatigue in IBD *** was a negative correlat