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Inhibiting wear particles-induced osteolysis with doxycycline

Acta Pharmacologica Sinica 2007年第10期28卷 1603-1610页

作者： Chao ZHANG~(1,2),Ting-ting TANG~1,Wei-ping REN~3,Xiao-ling ZHANG~2,Ke-rong DAI~(1,2,4)~1 Department of Orthopaedics,Ninth People's Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200011,China ~2 Institute ofHealth Sciences,Shanghai Institute for Biological Sciences,Chinese Academy of Sciences,Shanghai 200025,China,~3 Department of OrthopedicSurgery,Wayne State University School of Medicine and the John D Dingle VA Medical Center,Detroit 48201,USA Department of Orthopaedics Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China Institute of Health Sciences Shanghai Institute for Biological Sciences Chinese Academy of Sciences Shanghai China Department of Orthopedic Surgery Wayne State University School of Medicine and the John D Dingle VA Medical Center Detroit USA

Aim:To study the effect of doxycycline （DOX） on osteoclastogenesis,matureosteoclast fate and function,wear particles-induced osteoeolysis,and to providesome foundation for treating aseptic loosening and osteolysis after ***:Osteoclasts were generated from mouse bone marrowmonocytes with the receptor activator of NF-kB ligand and the macrophage colonystimulating *** at a concentration of 5,10,15,and 20 μg/mL was respec-tively added to the *** days later,the osteoclasts were determinedthrough tartrate-resistant acid phosphatase （TRAP） *** osteoclastswere isolated from newborn rabbits and cultured for 3 d in 24-well plates or onbone *** at a concentration of 5,10,15,and 20 μg/mL was respectivelyadded to the *** TRAP staining,the osteoclasts were counted,resorp-tion on bone slices was quantified,and the area was calculated after toluidine blueand Mayer-hematoxylin *** methacrylate （PMMA） or ultra-highmolecular weight polyethylene （UHMWPE） particles were implanted on thecalvariae of C57BL/J6 ***,at a dose of 2 and 10 mg·kg-1·d-1,was respec-tively given intraperitoneally for 7 *** days later,the calvariae were removedand processed for pathological ***:DOX treatment effectivelyinhibited in vitro osteoclastogenesis,affected the fate of mature osteoclasts,andinhibited mature osteoclasts,causing bone *** vivo data indicated thatDOX strongly inhibited PMMA or UHMWPE-induced osteolysis ***:DOX can effectively inhibit osteoclastogenesisand affect mature osteoclast fate and suppress wear particles induced by osteoly-sis and *** might be useful in the treatment or preventionof wear particles-induced osteolysis and aseptic loosening for its effect on osteo-clast generation and mature osteoclast fate and function.

关键词： wear particles osteolysis aseptic loosening doxycycline

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RECOGNITION OF wear particles IN LUBRICATING OIL USING LVQ NEURAL CLASSIFIER

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International Journal of Minerals,Metallurgy and Materials 1996年第1期10卷 30+26-30页

作者：王大东杨德斌徐金梧北京科技大学机械工程学院

A technique for wear particle identification using computer vision system is described. The computer vision system employs LVQ Neural Networks as classifier to recognize the surface texture of wear particles in lubricating oil and determine the conditions of machines. The recognition process includes four stages:(1)capturing image from ferrographies containing wear particles;(2) digitising the image and extracting features;(3) learning the training data selected from the feature data set;(4) identifying the wear particles and generating the result report of machine condition classification. To verify the technique proposed here, the recognition results of several typical classes of wear particles generated at the sliding and rolling surfaces in a diesel engine are presented.

关键词： computer vision wear particles ferrographic techniques neural networks,texture classification

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Targeted cancer therapies based on antibodies directed against epidermal growth factor receptor:status and perspectives

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Acta Pharmacologica Sinica 2007年第9期28卷 1476-1493页

作者： Zhenping ZHU Im Clone Systems Incorporated,New York,NY 10014,USA ImClone Systems Incorporated New York USA

Compelling experimental and clinical evidence suggests that epidermal growthfactor receptor (EGFR) plays an important role in the pathogenesis of a variety ofhuman cancers;thus,providing a strong rationale for the development of receptorantagonists as effective and specific therapeutic strategies for the treatment ofEGFR-expressing *** antibodies (mAb),owing to their highspecificity towards a given target,represent a unique class of novel cancertherapeutics.A number of anti-EGFR mAb are currently being developed in ourclinic,including two that have been approved by the United States Food andDrug Administration for the treatment of refractory metastatic colorectal cancer(mCRC) and squamous cell carcinomas of the head and neck (SCCHN).Cetuximab(Erbitux,IMC-C225),an IgG1 mAb,has demonstrated significant antitumor activity,both as a single agent and in combination with chemotherapeutics and radiation,in patients with refractory mCRC and SCCHN,***(Vectibix),an IgG2 mAb,has been approved as a single agent for the treatment ofpatients with refractory *** mAb,via blocking ligand/receptorinteractions,exert their biological activity via multiple mechanisms,includinginhibition of cell cycle progression,potentiation of cell apoptosis,inhibition ofDNA repair,inhibition of angiogenesis,tumor cell invasion and metastasis and,potentially,induction of immunological effector ***-EGFR anti-bodies have demonstrated good safety profiles and potent anticancer activity inour clinic and may prove to be efficacious agents in the treatment of a variety ofhuman malignancies.

关键词： wear particles osteolysis aseptic loosening doxycycline

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Comparison of the wear Behavior of UHMWPE Lubricated by Human Plasma and Brine

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Journal of China University of Mining and Technology 2007年第3期17卷 335-340页

作者： WANG Shi-bo GE Shi-rong NORM Gitis MICHAEL Vinogradov XIAO Jun Institute of Reliability Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China Center for Tribology Incorporated Campell California 95008 USA

The effect of plasma and brine lubricants on the friction and wear behavior of UHMWPE were studied by using the geometry of a Si3N4 ball sliding on a UHMWPE disc under patterns of uni-directional reciprocation and bi-directional sliding motions. The worn surface and wear particles produced in these two lubricants were analyzed. Sliding motion pattern affected the friction coefficients lubricated with plasma,while seldom affected that lubricated with brine. UHMWPE lubricated with plasma showed about half of the wear rate of that lubricated with brine. The two rates were 0.75 pg/m and 2.19 pg/m for the two motion patterns,respectively. However,wear particles generated in plasma included a greater amount of small particles,compared to that in brine. In uni-directional reciprocation,the main wear mechanism is ploughing both in plasma and in brine. In bi-directional sliding modes,the significant characteristic is ripples on the worn surface in plasma,while there are oriented fibers on the worn surface in brine.

关键词： UHMWPE wear lubrication wear particles wear mechanism

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The Production and Fracture Characteristrics of particles in Radial Sliding Bearing

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Journal of Wuhan University of Technology(Materials Science) 2004年第B10期19卷 49-51页

作者：吴刚 Wuhan University of Technology

Based on the running characteristics,the experimental results show that wear particles appear on the normal running *** fractural characteristics of wear particles were investigated, it is found there exists a relatio... 详细信息

关键词： sliding bearing wear particles fracture character

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An On-line Ferrograph for Monitoring Machine wear

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International Journal of Plant Engineering and Management 2005年第1期10卷 1-7页

作者： LUEXiao-jun JINGMin-qing XIEYou-bai InstituteofLubricationTheoryandBearing Xi＇anJiaotongUniversityXi＇an710049P.R.China InstituteofLubricationTheoryandBearing Xi＇anJiaotongUniversityXi＇an710049P.R.China

In order to improve an on-line ferrograph, this paper simulates a three-dimensional magnetic field distribution of an electromagnet, builds a sinking motion model of a wear particle, and investigates the motion law of wear particles under two different conditions. Both numeric results and experimental results show that the on-line ferrograph is capable of monitoring machine wear conditions by measuring the concentration and size distribution of wear particles in lubricating oil.

关键词： on-line ferrograph condition monitoring wear particles wear

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Platelet-derived Growth Factor-BB Attenuates TitaniumParticle-Induced Osteolysis In Vivo

Platelet-derived Growth Factor-BB Attenuates TitaniumParticl...

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2016年浙江省骨科学学术年会

作者： Ye Chenyi Zhang Wei Jiang Shuai Chen Xi He Rongxin Department of Orthopedics The Second Affiliated HospitalSchool of MedicineZhejiang University

Objective Inflammation and osteoclastogenesis play critical roles in wear-particle-induced periprosthetic osteolysis(WPO).Platelet-derived growth factor-BB(PDGF-BB) could promote osteogenesis and inhibit inflammatory *** aim of this study was to investigate the impact of PDGF-BB on *** Mice were divided into four groups,namely,sham,vehicle,low-,and high-dose PDGF-BB *** in the rhPDGF-BB groups were treated with PDGF-BB at 0.25 or 1 mg/ml/kg/*** in the sham and vehicle groups received PBS *** weeks after surgery,calvariae were *** Immunohistochemical analysis and u-CT showed that PDGF-BB significantly reduced osteoclast formation and bone *** showed that rhPDGF-BB decreased the secretion of TNF-α,IL-1β,and *** blotting revealed that rhPDGF-BB stimulated the expression of osteocalcin and ***,more VEGF and CD31 proteins were observed due to PDGF-BB by *** In conclusion,these findings suggest that rhPDGF-BB represents a potential treatment for WPO.

关键词： Osteolysis Arthroplasty PDGF-BB wear particles

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Microscope Debris Image Segmentation Based on the Fuzzy C-Mean Clustering

Microscope Debris Image Segmentation Based on the Fuzzy C-Me...

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第一届建立和谐人机环境联合学术会议（HHME2005）

作者： Xianzhong Tiao tongsen Hu Jian Zhang (Infornation Engineering College,Zhejiang University of technology,Hangzhao 310014)

This paper discusses microscope debris image segmentation based on the Fuzzy C-Mean clustering. First, we give the fuzzy C-Mean clustering algorithm(FCM) and its shortcoming; then, we give the weighti

关键词： image segmentation fuzzy clustering wear particles

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