Platelet-derived Growth Factor-BB Attenuates TitaniumParticle-Induced Osteolysis In Vivo
作者单位：Department of OrthopedicsThe Second Affiliated HospitalSchool of MedicineZhejiang University
会议名称：《2016年浙江省骨科学学术年会》
会议日期：2016年
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
关 键 词：Osteolysis Arthroplasty PDGF-BB Wear particles
摘 要：Objective Inflammation and osteoclastogenesis play critical roles in Wear-particle-induced periprosthetic osteolysis(WPO).Platelet-derived growth factor-BB(PDGF-BB) could promote osteogenesis and inhibit inflammatory *** aim of this study was to investigate the impact of PDGF-BB on *** Mice were divided into four groups,namely,sham,vehicle,low-,and high-dose PDGF-BB *** in the rhPDGF-BB groups were treated with PDGF-BB at 0.25 or 1 mg/ml/kg/*** in the sham and vehicle groups received PBS *** weeks after surgery,calvariae were *** Immunohistochemical analysis and u-CT showed that PDGF-BB significantly reduced osteoclast formation and bone *** showed that rhPDGF-BB decreased the secretion of TNF-α,IL-1β,and *** blotting revealed that rhPDGF-BB stimulated the expression of osteocalcin and ***,more VEGF and CD31 proteins were observed due to PDGF-BB by *** In conclusion,these findings suggest that rhPDGF-BB represents a potential treatment for WPO.