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Magnetic resonance morphometry of the loss of gray matter volume in Parkinson's disease patients

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Neural Regeneration Research 2013年第27期8卷 2557-2565页

作者： Jianguo Xia Juan Wang Weizhong Tian Hongbin Ding Qilin Wei Huanxin Huang Jun Wang Jinli Zhao Hongmei Gu Lemin Tang Department of Radiology Taizhou People's Hospital of Nantong University Department of Medical Image Engineering Medical School of Nantong University Department of Geriatrics Affiliated Hospital of Nantong University Department of Radiology Affiliated Hospital of Nantong University

voxel-based morphometry can be used to quantitatively compare structural differences and func-tional changes of gray matter in subjects. In the present study, we compared gray matter images of 32 patients with Parkinson’s disease and 25 healthy controls using voxel-based morphometry based on 3.0 T high-field magnetic resonance T1-weighted imaging and clinical neurological scale scores. Results showed that the scores in Mini-Mental State Examination and Montreal Cognitive Assessment were lower in patients compared with controls. In particular, the scores of visuospatial/executive function items in Montreal Cognitive Assessment were significantly reduced, but mean scores of non-motor symptoms significantly increased, in patients with Parkinson’s dis-ease. In addition, gray matter volume was significantly diminished in Parkinson’s disease patients compared with normal controls, including bilateral temporal lobe, bilateral occipital lobe, bilateral parietal lobe, bilateral frontal lobe, bilateral insular lobe, bilateral parahippocampal gyrus, bilateral amygdale, right uncus, and right posterior lobe of the cerebel um. These findings indicate that voxel-based morphometry can accurately and quantitatively assess the loss of gray matter volume in patients with Parkinson＇s disease, and provide essential neuroimaging evidence for multisystem pathological mechanisms involved in Parkinson’s disease.

关键词： neural regeneration neuroimaging neurodegeneration voxel-based morphometry Parkinson'sdisease MRI dopamine non-motor symptoms gray matter abnormality region of interest Mini-Mental State Examination Montreal Cognitive Assessment neurodegenerative disease grants-supported paper neuroregeneration

^(18)F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma

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Frontiers of Medicine 2021年第6期15卷 913-921页

作者： Chao Lu Kailiang Wang Fei Meng Yihe Wang Yongzhi Shan Penghu Wei Guoguang Zhao Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing100053China China International Neuroscience Institute(CHINA-INI) Beijing100053China Center of Epilepsy Beijing Institute for Brain DisorderBeijing100069China

Epileptogenic hypothalamic hamartoma is characterized by intractable gelastic seizures.A systematic analysis of the overall brain metabolic pattern in patients with hypothalamic hamartoma(HH)could facilitate the understanding of the epileptic brain network and the associated brain damage effects of *** this study,we retrospectively evaluated 27 patients with epileptogenic HH(8 female patients;age,2–33 years)by using ^(18)F-fluorodeoxyglucose-positron emission *** correlations among tomography result,seizure type,sex,and structural magnetic resonance imaging were *** metabolic patterns and voxel-based morphometry findings were assessed by group analysis with healthy *** of the whole metabolic pattern in patients with HH revealed several regional metabolic reductions in the cerebrum and an overall metabolic reduction in the *** addition,areas showing hypometabolism in the neocortex were more widely distributed ipsilaterally than contralaterally to the *** in glucose metabolism and gray matter volume in the neocortex were predominant ipsilateral to the *** conclusion,the glucose hypometabolism pattern in patients with epileptogenic HH involved the neocortex,subcortical regions,and *** characteristics of glucose hypometabolism differed across seizure type and *** in glucose metabolism and structural changes may be based on different mechanisms,but both are likely to occur ipsilateral to the HH in the *** hypothesized that the dentato-rubro-thalamic tract and cerebro-ponto-cerebellar tract,which are responsible for intercommunication between the cerebral cortex,subcortical regions,and cerebellar regions,may be involved in a pathway related to seizure propagation,particularly gelastic seizures,in patients with HH.

关键词： hypothalamic hamartoma gelastic seizure fluorodeoxyglucose-positron emission tomography voxel-based morphometry

Regional gray matter atrophy and neuropsychologcal problems in relapsing-remitting multiple sclerosis

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Neural Regeneration Research 2013年第21期8卷 1958-1965页

作者： Aiyu Lin Fuyong Chen Fang Liu Zhiwen Li Ying Liu Shifang Lin Xiaoyi Wang Jiting Zhu Department of Neurology the First Affiliated Hospital of Fujian Medical University Department of Neurosurgery the First Affiliated Hospital of Fujian Medical University Department of Hyperbaric Oxygen Treatment the First Affiliated Hospital of Fujian Medical University Department of Radiology The First Affiliated Hospital of Fujian Medical University

In multiple sclerosis, gray matter atrophy is extensive, and cognitive deficits and mood disorders are frequently encountered. It has been conjectured that focal atrophy is associated with emotional decline. However, conventional MRI has revealed that the pathological characteristics cannot fully account for the mood disorders. Moreover, there is no correlation between cognitive disorders and MRI results in clinically isolated syndromes or in cases of definite multiple sclerosis. In this casecontrol study, voxel-based morphometric analysis was performed on 11 subjects with relapsing-remitting multiple sclerosis, and the results show that these patients exhibit gray matter atrophy. Moreover, the gray matter atrophy in the superior and middle gyri of the right frontal lobe in patients with multiple sclerosis was correlated with scores from the Hamilton Anxiety Rating Scale. The scores obtained with the Repeatable Battery for the Assessment of Neuropsychological Status were associated with gray matter atrophy in the middle gyrus of the left frontal lobe, the superior and middle gyrus of the right frontal lobe, the middle gyrus of the left cingulate, the superior and middle gyri of the left frontal lobe, and the triangular area of the left frontal lobe. However, there was no statistical significance. These findings suggest that the cingulate and frontal cortices of the dominant hemisphere are the most severely atrophic regions of the brain, and this atrophy is correlated with cognitive decline and emotional abnormalities.

关键词： neural regeneration neurodegeneration MRI relapsing-remitting multiple sclerosis gray matter atrophy cognitive mood voxel-based morphometry neuroregeneration

Correlation between white matter damage and gray matter lesions in multiple sclerosis patients

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Neural Regeneration Research 2017年第5期12卷 787-794页

作者： Xue-mei Han Hong-ji Tian Zheng Han Ce Zhang Ying Liu Jie-bing Gu Rohit Bakshi Xia Cao First Department of Neurology China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Clinical Medicine School of Clinical MedicineJilin UniversityChangchunJilin ProvinceChina Department of Neurology Brigham and Women's HospitalLaboratory for Neuroimaging ResearchPartners MS CenterHarvard Medical SchoolBostonMAUSA School of Pharmaceutical Sciences Jilin UniversityChangchunJilin ProvinceChina

We observed the characteristics of white matter fibers and gray matter in multiple sclerosis patients, to identify changes in diffusion tensor imaging fractional anisotropy values following white matter fiber injury. We analyzed the correlation between fractional anisotropy values and changes in whole-brain gray matter volume. The participants included 20 patients with relapsing-remitting multiple sclerosis and 20 healthy volunteers as controls. All subjects underwent head magnetic resonance imaging and diffusion tensor imaging. Our results revealed that fractional anisotropy values decreased and gray matter volumes were reduced in the genu and splenium of corpus callosum, left anterior thalamic radiation, hippocampus, uncinate fasciculus, right corticospinal tract, bilateral cingulate gyri, and inferior longitudinal fasciculus in multiple sclerosis patients. Gray matter volumes were significantly different between the two groups in the right frontal lobe（superior frontal, middle frontal, precentral, and orbital gyri）, right parietal lobe（postcentral and inferior parietal gyri）, right temporal lobe（caudate nucleus）, right occipital lobe（middle occipital gyrus）, right insula, right parahippocampal gyrus, and left cingulate gyrus. The voxel sizes of atrophic gray matter positively correlated with fractional anisotropy values in white matter association fibers in the patient group. These findings suggest that white matter fiber bundles are extensively injured in multiple sclerosis patients. The main areas of gray matter atrophy in multiple sclerosis are the frontal lobe, parietal lobe, caudate nucleus, parahippocampal gyrus, and cingulate gyrus. Gray matter atrophy is strongly associated with white matter injury in multiple sclerosis patients, particularly with injury to association fibers.

关键词： nerve regeneration multiple sclerosis diffusion tensor imaging tract-based spatial statistics voxel-based morphometry gray matter white matter fractional anisotropy brain atrophy neural regeneration

Grey-matter volume as a potential feature for the classification of Alzheimer's disease and mild cognitive impairment: an exploratory study

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Neuroscience Bulletin 2014年第3期30卷 477-489页

作者： Yane Guo Zengqiang Zhang Bo Zhou Pan Wang Hongxiang Yao Minshao Yuan Ningyu An Haitao Dai Luning Wang Xi Zhang Yong Liu Department of Neurology Institute of Geriatrics and Gerontology Chinese PLA General Hospital Hainan Branch of Chinese PLA General Hospital Department of Radiology Chinese PLA General Hospital Department of Neurology the People's Hospital of Jimo Brainnetome Center Institute of Automation Chinese Academy of Sciences National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences

Specific patterns of brain atrophy may be helpful in the diagnosis of Alzheimer＇s disease （AD）. In the present study, we set out to evaluate the utility of grey-matter volume in the classification of AD and amnestic mild cognitive impairment （aMCI） compared to normal control （NC）individuals. voxel-based morphometric analyses were performed on structural MRIs from 35 AD patients, 27 aMCI patients, and 27 NC participants. A two-sample two-tailed t-test was computed between the NC and AD groups to create a map of abnormal grey matter in AD. The brain areas with significant differences were extracted as regions of interest （ROIs）, and the grey-matter volumes in the ROIs of the aMCI patients were included to evaluate the patterns of change across different disease severities. Next, correlation analyses between the grey-matter volumes in the ROIs and all clinical variables were performed in aMCI and AD patients to determine whether they varied with disease progression. The results revealed significantly decreased grey matter in the bilateral hippocampus/ parahippocampus, the bilateral superior/middle temporal gyri, and the right precuneus in AD *** grey-matter volumes with clinical variables were positively correlated Finally, we performed exploratory linear discriminative analyses to assess the classifying capacity of grey-matter volumes in the bilateral hippocampus and parahippocampus among AD, aMCI, and NC. Leave-one-out cross- validation analyses demonstrated that grey-matter volumes in hippocampus and parahippocampus accurately distinguished AD from NC. These findings indicate that grey-matter volumes are useful in the classification of AD.

关键词： Alzheimer's disease mild cognitive impairment voxel-based morphometry grey matter volume classification

Structural remodeling in related brain regions in patients with facial synkinesis

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Neural Regeneration Research 2021年第12期16卷 2528-2533页

作者： Jia-Jia Wu Ye-Chen Lu Mou-Xiong Zheng Xu-Yun Hua Chun-Lei Shan Wei Ding Jian-Guang Xu Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Wound Healing Center Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Trauma and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Facial synkinesis is a troublesome sequelae of facial nerve *** is difficult to recover from synkinesis,despite improved surgical techniques for isolating the peripheral facial nerve ***,it remains unclear whether long-term dysfunction of motor control can lead to irreversible plasticity-induced structural brain *** case-control study thus investigated the structural brain alterations associated with facial *** study was conducted at Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,*** patients with facial synkinesis(2 male and 18 female,aged 33.35±6.97 years)and 19 healthy volunteers(2 male and 17 female,aged 33.21±6.75 years)underwent magnetic resonance imaging,and voxel-based and surface-based morphometry techniques were used to analyze *** was no significant difference in brain volume between patients with facial synkinesis and healthy *** with facial synkinesis exhibited a significantly reduced cortical thickness in the contralateral superior and inferior temporal gyri and a reduced sulcal depth of the ipsilateral precuneus compared with healthy *** addition,sulcal depth of the ipsilateral precuneus was negatively correlated with the severity of *** findings suggest that there is a structural remodeling of gray matter in patients with facial synkinesis after facial nerve *** study was approved by the Ethics Review Committee of the Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,China(approval No.2017-365-T267)on September 13,2017,and was registered with the Chinese Clinical Trial Registry(registration number:ChiCTR1800014630)on January 25,2018.

关键词： brain plasticity cortical thickness depression facial nerve paralysis facial synkinesis peripheral nerve injury sulcal depth structural remodeling surface-based morphometry voxel-based morphometry

Healthy individuals vs patients with bipolar or unipolar depression in gray matter volume

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World Journal of Clinical Cases 2021年第6期9卷 1304-1317页

作者： Yin-Nan Zhang Hui Li Zhi-Wei Shen Chang Xu Yue-Jun Huang Ren-Hua Wu Department of Rehabilitation Medicine Mental Health Center of Shantou UniversityShantou 515000Guangdong ProvinceChina Mental Health Center of Shantou University Shantou 515000Guangdong ProvinceChina Philips Healthcare China Beijing 100000China Department of Pediatrics The Second Affiliated Hospital of Shantou University Medical CollegeShantou 515000Guangdong ProvinceChina Department of Medical Imaging The Second Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND Previous studies using voxel-based morphometry(VBM)revealed changes in gray matter volume(GMV)of patients with depression,but the differences between patients with bipolar disorder(BD)and unipolar depression(UD)are less *** To analyze the whole-brain GMV data of patients with untreated UD and BD compared with healthy *** Fourteen patients with BD and 20 with UD were recruited from the Mental Health Center of Shantou University between August 2014 and July 2015,and 20 nondepressive controls were *** routine three-plane positioning,axial T2WI scanning was *** connecting line between the anterior and posterior commissures was used as the scanning *** scanning range extended from the cranial apex to the foramen *** data are presented as frequencies and were analyzed using the Fisher exact *** There were no significant intergroup differences in gender,age,or years of *** course,age at the first episode,and Hamilton depression rating scale scores were similar between patients with UD and those with *** with the non-depressive controls,patients with BD showed smaller GMVs in the right inferior temporal gyrus,left middle temporal gyrus,right middle occipital gyrus,and right superior parietal gyrus and larger GMVs in the midbrain,left superior frontal gyrus,and right *** contrast,UD patients showed smaller GMVs than the controls in the right fusiform gyrus,left inferior occipital gyrus,left paracentral lobule,right superior and inferior temporal gyri,and the right posterior lobe of the cerebellum,and larger GMVs than the controls in the left posterior central gyrus and left middle frontal *** was no difference in GMV between patients with BD and *** Using VBM,the present study revealed that patients with UD and BD have different patterns of changes in GMV when compared with healthy controls.

关键词： Bipolar disorder Unipolar depression Gray matter Functional magnetic resonance imaging Classification techniques voxel-based morphometry

Using multimodal MRI to investigate alterations in brain structure and function in the BBZDR/Wor rat model of type 2 diabetes

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Animal Models and Experimental Medicine 2020年第4期3卷 285-294页

作者： Christopher M.Lawson Kilian F.G.Rentrup Xuezhu Cai Praveen P.Kulkarni Craig F.Ferris Center for Translational NeuroImaging Northeastern UniversityBostonMAUSA

Background:This is an exploratory study using multimodal magnetic resonance imaging(MRI)to interrogate the brain of rats with type 2 diabetes(T2DM)as compared to *** was hypothesized there would be changes in brain structure and function that reflected the human disorder,thus providing a model system by which to follow disease progression with noninvasive ***:The transgenic BBZDR/Wor rat,an animal model of T2MD,and agematched controls were studied for changes in brain structure using voxel-based morphometry,alteration in white and gray matter microarchitecture using diffusion weighted imaging with indices of anisotropy,and functional coupling using restingstate BOLD functional *** from each modality were registered to,and analyzed,using a 3D MRI rat atlas providing site-specific data on over 168 different brain ***:There was an overall reduction in brain volume focused primarily on the somatosensory cortex,cerebellum,and white matter *** putative changes in white and gray matter microarchitecture were pervasive affecting much of the brain and not localized to any *** was a general increase in connectivity in T2DM rats as compared to *** cerebellum presented with strong functional coupling to pons and brainstem in T2DM rats but negative connectivity to ***:The neuroradiological measures collected in BBBKZ/Wor rats using multimodal imaging methods did not reflect those reported for T2DB patients in the *** data would suggest the BBBKZ/Wor rat is not an appropriate imaging model for T2DM.

关键词： BBZDR/Wor rat diffusion weighted imaging magnetic resonance imaging resting-state BOLD functional imaging small vessel disease voxel-based morphometry

voxel-based Morphometric Study on Chinese Blind Men's Brain Structure

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Journal of Beijing Institute of Technology 2007年第1期16卷 56-60页

作者：杨春兰潘文举郑链 School of Aerospace Science and Engineering Beijing Institute of Technology Beijing 100081 China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of Science Wuhan 430071 China School of Aerospace Science and Engineering Beijing Institute of TechnologyBeijing 100081 China

Many studies have shown the functional relevance of cross-modal plasticity in blind men. In order to study the changes of their brain structure, voxel-based morphometry （VBM） methods are used. The regional gray matter （GM） and white matter （WM） concentrations of magnetic resonance （MR） images from 11 blind people and 9 sighted control subjects are compared using standard VBM. Optimized VBM is also discussed to measure the absolute local volume of GM or WM. Consistent results are achieved by statistical analysis with these methods. There are distinct differences not only in visual cortex but also the sensory area, auditory area and motor area. GM concentrations in blind men significantly decreased in Brodmann 7 and 22. While in Brodmann 18 and 19, GM concentration increased. GM volumes decreased in Brodmann 3, 4, 6, 9 and 45. On the other hand, both WM concentration and volume increased in Brodmann 7. These results suggest that early visual deprivation can lead to changes in the brain structural anatomy which is consistent with the cortical cross-modal reorganization found by functional imaging. It may help to discover the relationship between the brain structural anatomy and the brain functional data of blind men at a macroscopic level from neuroimaging perspective.

关键词： blind men brain structure voxel-based morphometry