Using multimodal MRI to investigate alterations in brain structure and function in the BBZDR/Wor rat model of type 2 diabetes

作     者：Christopher M.Lawson Kilian F.G.Rentrup Xuezhu Cai Praveen P.Kulkarni Craig F.Ferris Christopher M.Lawson;Kilian F.G.Rentrup;Xuezhu Cai;Praveen P.Kulkarni;Craig F.Ferris

作者机构：Center for Translational NeuroImagingNortheastern UniversityBostonMAUSA 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2020年第3卷第4期

页      面：285-294页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：The financial support was provided in part by an HHMI-funded Inclusive Excellence Award to Northeastern University PIOndrechen 

主　　题：BBZDR/Wor rat diffusion weighted imaging magnetic resonance imaging resting-state BOLD functional imaging small vessel disease voxel-based morphometry 

摘      要：Background:This is an exploratory study using multimodal magnetic resonance imaging(MRI)to interrogate the brain of rats with type 2 diabetes(T2DM)as compared to *** was hypothesized there would be changes in brain structure and function that reflected the human disorder,thus providing a model system by which to follow disease progression with noninvasive ***:The transgenic BBZDR/Wor rat,an animal model of T2MD,and agematched controls were studied for changes in brain structure using voxel-based morphometry,alteration in white and gray matter microarchitecture using diffusion weighted imaging with indices of anisotropy,and functional coupling using restingstate BOLD functional *** from each modality were registered to,and analyzed,using a 3D MRI rat atlas providing site-specific data on over 168 different brain ***:There was an overall reduction in brain volume focused primarily on the somatosensory cortex,cerebellum,and white matter *** putative changes in white and gray matter microarchitecture were pervasive affecting much of the brain and not localized to any *** was a general increase in connectivity in T2DM rats as compared to *** cerebellum presented with strong functional coupling to pons and brainstem in T2DM rats but negative connectivity to ***:The neuroradiological measures collected in BBBKZ/Wor rats using multimodal imaging methods did not reflect those reported for T2DB patients in the *** data would suggest the BBBKZ/Wor rat is not an appropriate imaging model for T2DM.