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Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers

World Journal of Diabetes 2020年第7期11卷 309-321页

作者： Banu Buyukaydin Eray Metin Guler Tahsin Karaaslan Atilla Olgac Mehmet Zorlu Muharrem Kiskac Abdurrahim Kocyigit Department of Internal Medicine Bezmialem Vakif University Medical FacultyIstanbul 34093Turkey Department of Medical Biochemistry Bezmialem Vakif University Medical FacultyIstanbul 34093Turkey Department of Nephrology Istanbul Medeniyet University Medical FacultyIstanbul 34093Turkey

BACKGROUND Diabetic polyneuropathy is a very common complication of *** studies are available in terms of *** examination methods with low reliability are still not standardized and generally time ***,easy-to-access methods are *** markers are one of the subjects of *** aimed to discover a potential biomarker that can be used for this purpose in patients with diabetes who have not yet developed symptoms of *** To determine the place and availability of visfatin and thiol-disulfide homeostasis in this *** A total of 392 patients with type 2 diabetes mellitus were included in the *** polyneuropathy clinical signs were evaluated with the Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire and *** biochemical parameters,oxidative stress markers,visfatin,and thiol-disulfide homeostasis were analyzed and correlated with each other and clinical *** Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire with examination scores were correlated with each other and diabetes duration(Pvisfatin were positively correlated with each ***,these parameters were positively correlated with the total oxidative stress *** and native thiol was positively correlated with total antioxidant status and negatively with oxidant *** thiol-disulfide positively correlated with higher glucose and oxidant status and negatively with total antioxidant status(Pvisfatin and thiol-disulphide(P=0.092,r=0.086).However,a significant negative correlation was observed between visfatin and total with native thiol(P<0.005,r=-0.

关键词： Diabetic neuropathy Diabetic foot Early detection Oxidative stress Thioldisulfide visfatin protein

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