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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2973-3012页

作者： Andrew Omame Mujahid Abbas Dumitru baleanu Department of Mathematics Federal University of TechnologyOwerri460114Nigeria Abdus Salam School of Mathematical Sciences Government College UniversityLahore54000Pakistan Department of Mathematics Government College UniversityLahore54000Pakistan Department of Computer Science and Mathematics Labanese American UniversityBeirutLebanon Institute of Space Sciences Magurele-BucharestRomania Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40402Taiwan

A patient co-infected with COVID-19 and viral hepatitis b can be atmore risk of severe complications than the one infected with a single *** study develops a comprehensive stochastic model to assess the epidemiological impact of vaccine booster doses on the co-dynamics of viral hepatitis b and *** model is fitted to real COVID-19 data from *** proposed model incorporates logistic growth and saturated incidence *** analyses using the tools of stochastic calculus,are performed to study appropriate conditions for the existence of unique global solutions,stationary distribution in the sense of ergodicity and disease *** stochastic threshold estimated from the data fitting is given by:R_(0)^(S)=*** assessments are implemented to illustrate the impact of double-dose vaccination and saturated incidence functions on the dynamics of both *** effects of stochastic white noise intensities are also highlighted.

关键词： viral hepatitis b COVID-19 stochastic model extinction ergodicity real data

Prevalence of Children Vaccinated against viral hepatitis b in brazzaville

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Open Journal of Pediatrics 2024年第2期14卷 426-434页

作者： Lucie Charlotte Ollandzobo Ikobo Farrèche Colombe Missidi Hostaud bienvenu Atipo-Ibara Arnaud Mongo Onkouo Clausina Philestine Ahoui Apendi Jile Florent Mimiesse blaise Irénée Atipo Ibara Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo Infant Paediatrics Department Brazzaville University Hospital Brazzaville Republic of the Congo Gastroenterology and Internal Medicine Department Brazzaville University Hospital Brazzaville Republic of the Congo

Introduction: viral hepatitis b (VHL) is a public health problem, particularly in sub-Sahara Africa. The aim of this study was to assess vaccination coverage against HbV in children in brazzaville. Patients and Methods: This was a cross-sectional analytical study conducted in brazzaville health centres from January to September 2019. It involved children aged between six months and six years who received a vaccination against HbV. Sampling was exhaustive and based on stratified sampling. Results: The overall prevalence of children vaccinated against HbV in brazzaville was 96.2%. It was insufficient in the Talangai health district (79%). The pentavalent vaccine was administered to 97.7% of children, 85% of whom had received all three doses. The reasons for incomplete vaccination were parents’ ignorance of HVb (85.6%) and of vaccination (14.3%). Conclusion: Although the prevalence of vaccinated children is high in brazzaville, it is still insufficient in some health districts, particularly Talangai, because parents are unaware of the disease and of vaccination. Pentavalent is the only vaccine available in the national vaccination programme, which is why an effective national vaccination policy needs to be put in place. .

关键词： Prevalence Vaccination viral hepatitis b Child brazzaville

viral hepatitis b under Tenofovir in Ouagadougou (burkina Faso)

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Open Journal of Gastroenterology 2021年第8期11卷 141-150页

作者： Soudré Sandrine Marie-Odile bobilwindé Napon Fahosiata Zoungrana Steve Léonce Ouattara Zanga Damien Koura Mali Guingané Nanelin Alice Somda Sosthène Coulibaly Aboubacar beni Da Nathalie Salou Rodrigue bougouma Alain Sombié Arsène Roger Hepato-Gastroenterology Unit of the University Hospital Tengandogo Burkina Faso Africa Hepato-Gastroenterology Unit of the University Hospital Ouahigouya Burkina Faso Africa Gastroenterology Service of the University Hospital Souro Sanou Bobo-Dioulasso Burkina Faso Africa Gastroenterology Service of the University Hospital bogodogo Ouagadougou Burkina Faso Africa Gastroenterology Service of the University Hospital Yalgado Ouédraogo Ouagadougou Burkina Faso Africa

Introduction: The treatment of viral hepatitis b is based on nucleotide analogs(s). In burkina Faso, tenofovir is the most widely used because of its effectiveness and cost. The aim of this study was to describe viral... 详细信息

Introduction: The treatment of viral hepatitis B is based on nucleotide analogs(s). In Burkina Faso, tenofovir is the most widely used because of its effectiveness and cost. The aim of this study was to describe viral hepatitis B under tenofovir in Ouagadougou. Material and Method: This was a longitudinal study, carried out in the outpatient department of the University Hospital of Tengandogo from May 1, 2013 to September 31, 2020, i.e. a period of seven (07) years and five (05) months. All patients with chronic hepatitis B virus who had been taking tenofovir for at least one year were included in the study. Cases of hepatocellular carcinoma and co-infections with hepatitis D, C and human immunodeficiency viruses were excluded from the study. Results: Of 321 patients with hepatitis B, 120 were on tenofovir and 34 were included in our study. These were 24 men and 10 women with an average age of 39 years. Hepatitis B was most often discovered following systematic or voluntary screening (44.1%) or pain in the right hypochondrium (23.5%). The mean initial viral load was 7.9 log. Ten patients had moderate compliance and four were non-compliant. No side effects were reported in 91.3% of cases. The virologic response was complete in 72.7% of patients after six months. Nine out of ten patients showed a biochemical response after 16 months. A histological response was observed in 19/27 patients within a mean of 26.7 months. HBs seroconversion was found in 2/24 patients. Conclusion: Tenofovir is effective in the treatment of viral hepatitis B, but HBs seroconversion is rarely achieved.

关键词： viral hepatitis b Tenofovir Compliance Tolerance Efficacy

Chronic hepatitis b Virus Infection: biological Parameters in Patients Treated with Tenofovir Disoproxil Fumarate

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Open Journal of Gastroenterology 2024年第4期14卷 145-151页

作者： Sanra Déborah Sanogo Moussa Y. Dicko Lamine N’Diaye Ousmane Diarra Drissa Katilé Abdoulaye Maiga Ouatou Mallé Sabine Drabo Makan S. Tounkara Hourouma Sow Kadiatou Doumbia Anselme Konaté Moussa T. Diarra Hepato-Gastroenterology Department Centre Hospitalier Universitaire Du Point G Bamako Mali Hepato-Gastroenterology Department Gabriel Toure University Hospital Bamako Mali Hepato-Gastroenterology Unit Csref Commune V Bamako Mali

Chronic hepatitis b causes a liver disease characterized by inflammation of the liver parenchyma. The aim of this study was to investigate the evolution of biological parameters in patients treated with Tenofovir for chronic b infection at the Commune V referral health center in bamako. We obtained a prevalence of 14.15%. The most represented age group was 31 - 40 years, with 36.8%. The sex ratio was 1.44 in favour of men. viral load was undetectable after 18 months of treatment in 25 patients (42.37%). Tenofovir, the 1st-line drug in Mali, is effective on the biological parameters monitored in patients.

关键词： viral hepatitis b Tenofovir biological Parameters

Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis b： a case report

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Frontiers of Medicine 2014年第2期8卷 250-253页

作者： Lei Li Yimei Liu Tiancheng Luo Jian Zhou Yingyong Hou Xizhong Shen Jiyao Wang Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Liver Surgery Zhongshan Hospital Fudan University Shanghai 200032 China Department of Pathology Zhongshan Hospital Fudan University Shanghai 200032 China Shanghai Institute of Liver Diseases Shanghai 200032 China

The clinical data of a patient with acute-on-chronic liver failure were analyzed retrospectively. The patient has suffered from hepatitis b for 30 years. His liver function deteriorated, yielding Child-Pugh grade C and reaching a model for end-stage liver disease score of 33 points within a short period; this condition was complicated with highly active variceal bleeding and coagulation system failure （PT 〉 100 s）. The patient also presented hepatocellular carcinoma. Comprehensive treatments included effective inhibition of hepatitis b virus replication and intensive care support. Piggyback orthotopic liver transplantation was performed as the final treatment. The patient recovered uneventfully and was discharged after surgery.

关键词： acute-on-chronic liver failure submassive necrosis viral hepatitis b esophageal variceal bleeding liver transplantation

Epidemiology and transmission of hepatitis b and C viruses in Kazakhstan

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World Journal of Gastroenterology 2007年第8期13卷 1204-1207页

作者： Zhannat Z Nurgalieva F blaine Hollinger David Y Graham S Zhangabylova Abai Zhangabylov Department of Faculty Therapy Kazakh National Medical University named after SD Asfendiarov Almaty Kazakhstan Department of Medicine VA Medical Center and Baylor College of Medicine Baylor College of Medicine Houston TX United States Department of MolecularVirology and Microbiology baylor College of Medicine Houston TX United States Department of Medicine VA Medical Center and Baylor College of Medicine Baylor College of Medicine Houston TX United States Department of Faculty Therapy Kazakh National Medical University named after SD Asfendiarov Almaty Kazakhstan

AIM: To investigate the epidemiology of hepatitis b virus (HbV) and hepatitis C virus (HCV) infection in the two major ethnic groups in Kazakhstan. METHODS: A cross-sectional prospective study of HbV and HCV seroprevalence was performed among individuals born in Kazakhstan with no history of chronic hepatitis or liver disease. RESULTS: There were 290 volunteers (140 Russians and 150 Kazakhs) aged 10 to 64 years, males accounted for 46%. Active HbV infection (HbsAg positive) was present in 3.8%, anti-Hbc in 30%. The prevalence was similar in females and males (33% vs 25%) (P = 0.18). The prevalence of anti-Hbc increased from 19% in 10-29 years old volunteers to 53% in 50-years and older volunteers. The prevalence of HbV infection was higher in married than in single adults (38% vs 26%, respectively) (P = 0.2) and more common in Kazakhs (35%) than in Russians (24%) (P = 0.07). HCV infection was present in 9 subjects (3.2%), 5 of them also were positive for anti-Hbc in the absence of HbsAg. CONCLUSION: The frequency of active HbV infection (3.8%) coupled with a high prevalence of HbV exposure in those > 50 years of age increases with age, which suggests that horizontal transmission likely relates tothe use of contaminated needles. The low prevalence of HCV infection suggests that HbV and HCV are acquired differently in this group of subjects.

关键词： viral hepatitis b viral hepatitis C hepatitis b virus Transmission Epidemiology Sero-epidemiology Kazakhstan

Challenges in the discontinuation of chronic hepatitis b antiviral agents

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World Journal of Hepatology 2021年第9期13卷 1042-1057页

作者： Apichat Kaewdech Pimsiri Sripongpun Department of Internal Medicine Faculty of MedicinePrince of Songkla UniversityHat Yai 90110SongkhlaThailand

Long-term antiviral treatment of chronic hepatitis b patients has been proven to be beneficial in reducing liver-related ***,lengthy periods of daily administration of medication have some inevitable drawbacks,including decreased medication adherence,increased cost of treatment,and possible longterm side ***,discontinuation of antiviral agent has become the strategy of interest to many hepatologists,as it might alleviate the aforementioned drawbacks and increase the probability of achieving functional *** review focuses on the current evidence of the outcomes following stopping antiviral treatment and the factors associated with subsequent hepatitis b virus relapse,hepatitis b surface antigen clearance,and unmet needs.

关键词： viral hepatitis b Relapse Retreatment SCALE-b Stop treatment strategy Nucleoside analogs

Factors Associated with Antigen Hbs Seroconversion among blood Donors in Ouagadougou from 2008 to 2017

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Advances in Infectious Diseases 2021年第3期11卷 278-289页

作者： Abdoul-Guaniyi Sawadogo T. Isidore Traore Salam Sawadogo Kompingnin Nebie Lucien Désiré Dahourou Juste Some Hervé Kpoda Ahmed Kabore Dahourou Honorine Arzouma Paul Yooda bia Emile Drabo Jean-Etienne Koanda Alain Konseybo Eléonore Kafando Nicolas Meda Léon blaise Savadogo Centre National de Transfusion Sanguine (CNTS) Ouagadougou Burkina Faso ONG Terre des hommes Lausanne Ouagadougou Burkina Faso Centre MURAZ Bobo-Dioulasso Burkina Faso Université Nazi bONI Bobo-Dioulasso Burkina Faso Université Joseph KI-ZERbO Ouagadougou Burkina Faso Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso Université Norbert ZONGO Koudougou Burkina Faso

Introduction: The risk of transmission of pathogens such as hepatitis b virus threatens the safety of transfused patients especially in high endemic areas. The aim of this study was to determine the incidence and factors associated with hepatitis b virus surface antigen (HbsAg) seroconversion in blood donors at the Regional blood Transfusion Centre of Ouagadougou. Methods: A retrospective cohort study of voluntary non-remunerated blood donors (VNRbD), was conducted from 2008 to 2017. Data on HbsAg seroconversion were collected. The Kaplan-Meier method and the Log-Rank test were used to estimate the survival curves. Cox’s regression identified the factors associated with this seroconversion. Results: Of 23,494 donors, 559 had HbsAg seroconversion. The number of donor years was 58,637.50 and the HbV incidence rate was 9.53 per 1000 donor years. The median seroconversion time was 75.73 months with extremes of 2.7 months and 107.12 months. The risk of seroconversion was 1.30 times higher among donors aged 21 to 24 years old (p = 0.007) and 2.49 times higher among those over 24 years old (p bsAg seroconversion (Hazard ratio = 1.12;p = 0.36). The risk of seroconversion decreased significantly with the number of blood donations (Hazard ratio = 0.58;p = 0.006). Conclusion: The incidence of HbsAg remains high among blood donors, which could have a negative impact on transfusion safety. The age of the blood donor was significantly associated to AgHbs seroconversion.

关键词： Time to Onset viral hepatitis b blood Donors Seroconversion

Chronic Carriage of hepatitis b Virus at the University Teaching Hospital Yalgado Ouedraogo: Therapeutic Aspects and Outcome in a Cohort of HbeAg+ Outpatients

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Open Journal of Epidemiology 2021年第3期11卷 245-255页

作者： Eric Nagaonlé Somé Félicité W. Nana bertrand I. Méda Moussa Son Drabo Maxime Séni Kouanda Roger Sombié biomedical and Public Health Department Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso Gastro-Enterology Department UFR des Sciences de la Santé Université Joseph Ki-Zerbo Ouagadougou Burkina Faso

Introduction: The HbsAg prevalence in burkina Faso was 9.1%. We aimed at describing the therapeutic features and the clinical outcome for the patients taking antiretroviral treatment. Materials and Methods: We implemented a cross-sectional study from January 1st, 2004 to December 31st, 2015. Patients aged more than 15 years with positive hepatitis b surface antigen for over six months and positive hepatitis b e-antigen were included. Results: We analyzed the data of 148 participants for a sex ratio of 3;sixty-three patients including 49 men (77.8%) were on treatment. and 81.5% had inflammatory activity greater than one. Under tenofovir, the normalization of ALT was observed in 42 (84%) patients while HbV-DNA became undetectable in 24/33 patients. HbeAg negativation was observed in 16/25 (64%) patients after seven years of treatment. With lamivudine, 2/9 patients had a complete virologic response and six had a normalization of their ALT. Two and 9 patients lost HbeAg after 7 and 9 years of treatment, respectively. Overall 63% and 27% of the patients were in the high or low-adherence group, respectively. In the low-adherence group, all patients had normal or abnormal ALT, but detectable HbV DNA. Ten patients taking lamivudine developed resistance including primary resistance in three patients. No resistance has been observed with tenofovir. Conclusion: The management of the viral hepatitis b includes often a long follow up period without any medication. When antiviral is indicated, the adherence to the treatment is crucial to a long-term control of the virus. In our setting, the low purchase power of the patients may jeopardize their therapeutic future and there is a need to support this group of patients with free-of-charge medicines as it is provided for the HIV infected people.

关键词： viral hepatitis b Hbe Antigen Antiretroviral Therapy Adherence Resistance

Knowledge, Attitudes and Practices of Persons Infected with the hepatitis b Virus on Their Own Disease

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Open Journal of Gastroenterology 2022年第4期12卷 119-127页

作者： Arnaud Mongo-Onkouo Ngala Akoa Itoua-Ngaporo Clausina Philestine Ahoui Apendi Jile Florent Mimiesse Monamou Rody Ngami Marlyse Ngalessami Mouakosso Mardoché Motoula Latou Deby Gassaye blaise Irénée Atipo Ibara Jean-Rosaire Ibara Department of Hepatogastroenterology and Internal Medicine Brazzaville Hospital and Universitary Center Brazzaville Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo

Introduction: viral hepatitis b is a communicable disease that is preventable by vaccination. Knowledge of transmission routes and prevention methods could play a key role in limiting and reducing the spread of the disease. Aim: This was a prospective study that was carried out from July 1 to September 30, 2018 in the department of gastroenterology and internal medicine in people carrying the hepatitis b virus. All patients were asked about their knowledge, attitudes and practices regarding viral hepatitis b. Materials and Methods: This was a cross-sectional study, collecting prospective data, which was carried out from July 1 to September 30, 2018 in the gastroenterology department of CHUb (University Hospital of brazzaville). Eligible for the study were all patients who consulted or were followed in the ward for HbV infection during the study period. All patients were asked about their knowledge, attitudes and practices regarding viral hepatitis b. After obtaining informed consent, we asked patients about knowledge, attitudes and practices towards the hepatitis b virus. The data was collected on a pre-established survey sheet respecting anonymity and confidentiality. CSPro 7 software and SPSS 17 software were used for data entry and analysis. Chi-square was used to compare the percentages. These were expressed with their 95% confidence intervals [95% CI]. A value of p 0.005 was considered significant. Results: Forty-two patients were included in the study, these were 66.7% (n = 28) men and 33.3% (n = 14) women. The average age was 38.76 ± 10.9 years. 45.2% of them (n = 19) were single and 59.5% (n = 25) had the next highest level of education. Thirty-nine patients had no knowledge of the source of their contamination;the sexual route was the most cited (61.9%). Alcohol consumption was rated badly by 38 patients (90.5%);of these 22 (52.4%) thought it worsened the disease. Lack of knowledge of an HbV carrier in the family was noted in 33 (78.6%) patients;20 (47.6%)

关键词： viral hepatitis b Knowledge Attitudes Practices Carriers brazzaville