Epidemiology and transmission of hepatitis B and C viruses in Kazakhstan

作     者：Zhannat Z Nurgalieva F Blaine Hollinger David Y Graham S Zhangabylova Abai Zhangabylov 

作者机构：Department of Faculty Therapy Kazakh National Medical University named after SD Asfendiarov Almaty Kazakhstan Department of Medicine VA Medical Center and Baylor College of Medicine Baylor College of Medicine Houston TX United States Department of MolecularVirology and Microbiology Baylor College of Medicine Houston TX United States Department of Medicine VA Medical Center and Baylor College of Medicine Baylor College of Medicine Houston TX United States Department of Faculty Therapy Kazakh National Medical University named after SD Asfendiarov Almaty Kazakhstan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2007年第13卷第8期

页      面：1204-1207页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：the Office of Research and Development Medical Research Service Department of Veterans Affairs Public Health Service grant DK56338 which funds the Texas Gulf Coast Digestive Diseases Center the Eugene B. Casey Foundation and the William and Sonya Carpenter Fund, Baylor College of Medicine 

主　　题：Viral hepatitis B Viral hepatitis C Hepatitis B virus Transmission Epidemiology Sero-epidemiology Kazakhstan 

摘      要：AIM: To investigate the epidemiology of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in the two major ethnic groups in Kazakhstan. METHODS: A cross-sectional prospective study of HBV and HCV seroprevalence was performed among individuals born in Kazakhstan with no history of chronic hepatitis or liver disease. RESULTS: There were 290 volunteers (140 Russians and 150 Kazakhs) aged 10 to 64 years, males accounted for 46%. Active HBV infection (HBsAg positive) was present in 3.8%, anti-HBc in 30%. The prevalence was similar in females and males (33% vs 25%) (P = 0.18). The prevalence of anti-HBc increased from 19% in 10-29 years old volunteers to 53% in 50-years and older volunteers. The prevalence of HBV infection was higher in married than in single adults (38% vs 26%, respectively) (P = 0.2) and more common in Kazakhs (35%) than in Russians (24%) (P = 0.07). HCV infection was present in 9 subjects (3.2%), 5 of them also were positive for anti-HBc in the absence of HBsAg. CONCLUSION: The frequency of active HBV infection (3.8%) coupled with a high prevalence of HBV exposure in those 50 years of age increases with age, which suggests that horizontal transmission likely relates tothe use of contaminated needles. The low prevalence of HCV infection suggests that HBV and HCV are acquired differently in this group of subjects.