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Immunohistochemistry of Dopamine and Norepinephrine in Human Placental villi

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Chinese Science Bulletin 1994年第17期39卷 1477-1480页

作者：石佳黄威权张崇理 State Key Laboratory of Reproductive Biology Institute of Zoology Academia Sinica Beijing 100080 PRC Department of Histology and Embryology the Fourth Military Medical College Xi'an 710032 PRC.

Most of the reports on human placental villi endocrinology focus on the study of neuropeptides, pituitary-or gonadal-like hormones, growth factors and cytokines, and only a few of them concern the function of biogenic... 详细信息

关键词： dopamine norepinephrine tyrosine hydrozylase human placental villi immunohistochemistry.

Effect of Mifepristone on Transforming Growth Factor -βand its Receptor Transcription in Decidua, villi and Serum Tumor Necrosis Factor -α Level in Early Human Gestation

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Journal of Reproduction and Contraception 2004年第1期15卷 33-38页

作者： Li-pingJIN Da-jinLI Jing-yuSHAO Song-guoZHENG Xue-zheWU LaboratoryofReproductiveImmunology InstituteofObstetricsandGynecologyFudanUniversityShanghai200011China ShanghaiFirstMaternity＆InfantHealthHospital Shanghai200040China LaboratoryofMolecularBiology TumorHospitalFudanUniversityShanghai200032China

Objective To investigate the role of mifepristone in regulating cytokines of materno-fetal interface and serum of human early gestationMethods Thirty-five women with early pregnancy received mifepristone 50 mg orallyon study d 1 and d 2, respectively, followed by undergoing artificial abortion to getdecidua and villi on study d 3. Twenty-five women with early pregnancy withoutmifepristone administration as control also underwent artificial abortion to get de-cidua and villi. The expressions of TGF-β1 and TGF-β1 receptor mRNA in the earlydecidua and villi were assessed by using RT-PCR . The concentrations of serum TNF-α were measured by *** The decidual expressions of TGF- β1 mRNA and TGF-β1 receptor mRNA in thetreated group were significantly lower than those of the control (P0.05). The serum TNF-β1 levelselevated significantly after mifepristone *** The antigestational effect of mifepristone might act through suppressingthe transcription of TGF-β1 and TGF-β1 receptor in the decidua and increasing theserum TNF-α level, which interfered in the materno-fetal interface Th2 bias.

关键词： Mifepristone deciduas villi transforming growth factor-β tumor necrosis factor-α

The contents and effect of angiotensin Ⅱ on hCG release in human placental villi during the first trimester of gestation

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生殖医学杂志 1995年第S1期4卷 25-30页

作者：王红邹爱民焦丽红陈忠科

ＴｈｅｃｏｎｔｅｎｔｓａｎｄｅｆｆｅｃｔｏｆａｎｇｉｏｔｅｎｓｉｎⅡｏｎｈＣＧｒｅｌｅａｓｅｉｎｈｕｍａｎｐｌａｃｅｎｔａｌｖｉｌｌｉｄｕｒｉｎｇｔｈｅｆｉｒｓｔｔｒｉｍｅｓｔｅｒｏｆｇｅｓｔａｔｉｏｎＷａｎｇＨｏｎ... 详细信息

ＴｈｅｃｏｎｔｅｎｔｓａｎｄｅｆｆｅｃｔｏｆａｎｇｉｏｔｅｎｓｉｎⅡｏｎｈＣＧｒｅｌｅａｓｅｉｎｈｕｍａｎｐｌａｃｅｎｔａｌｖｉｌｌｉｄｕｒｉｎｇｔｈｅｆｉｒｓｔｔｒｉｍｅｓｔｅｒｏｆｇｅｓｔａｔｉｏｎＷａｎｇＨｏｎｇ（王红），ＺｏｕＡｉｍｉｎ（邹爱...

关键词： hCG Angiotensin II Placental villi Gestation

ASAP3 regulates microvilli structure in parietal cells and presents intervention target for gastric acidity

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Signal Transduction and Targeted Therapy 2017年第1期2卷 274-284页

作者： Jin Qian Yueyuan Li Han Yao Haiying Tian Huanbin Wang Luoyan Ai Yuanhong Xie Yujie Bao Lunxi Liang Ye Hu Yao Zhang Jilin Wang Chushu Li Jiayin Tang Yingxuan Chen Jie Xu Jing-Yuan Fang Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and HepatologyMinistry of HealthState Key Laboratory for Oncogenes and Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai Institute of Digestive DiseaseShanghaiChina

Gastric acidity-associated disorders such as peptic ulcer and reflux diseases are widespread,and the reported resistance and side effects of currently used medicines suggest an urgent requirement for alternative therapeutic *** we demonstrate a critical role of ASAP3 in regulating the microvilli structure of parietal cells in vivo,and reveal the feasibility of controlling gastric acidity by targeting *** knockout of ASAP3 in mice caused elongation and stacking of microvilli in parietal cells,and substantially decreased gastric acid *** were associated with active assembly of F-actin caused by a higher level of GTP-bound Arf6 ***,a small molecular compound QS11 inhibited ASAP3 function and significantly reduced gastric acidity in *** note,the expression of ASAP3 was positively correlated with gastric acid secretion in 90 human cases,and high expression of ASAP3 was associated with reflux disease and peptic *** results reveal for the first time that ASAP3 regulates the microvilli structures in parietal *** data also suggest ASAP3 as a feasible and drugable therapeutic target for gastric acidity-associated diseases.

关键词： gastric villi inhibited

Effects of creep feeding and supplemental glutamine or glutamine plus glutamate (Aminogut) on pre- and post-weaning growth performance and intestinal health of piglets

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Journal of Animal Science and Biotechnology 2013年第3期4卷 211-222页

作者： Rafael A Cabrera James L Usry Consuelo Arrellano Eduardo T Nogueira Marianne Kutschenko Adam J Moeser Jack Odle Laboratory of Developmental Nutrition Department of Animal ScienceNorth Carolina State University 101 Polk Hall North Carolina State UniversityRaleigh NC 27695 USA Huvepharma USA 525 West Park Drive Suite 230 Peachtree City GA 30269 USA Ajinomoto Heartland Lysine Department of Statistics North Carolina State UniversityRaleigh NC 27695-8203 USA Ajinomoto do Brasil. Ajinomoto Animal Nutrition Sāo Paulo SP 04015-001 Brazil Department of Population Health and Pathobiology College of Veterinary Medicine North Carolina State UniversityRaleigh NC 27695 USA Laboratory of Developmental Nutrition Department of Animal ScienceNorth Carolina State University 101 Polk Hall North Carolina State UniversityRaleigh NC 27695 USA

Background： Creep feeding is used to stimulate piglet post-weaning feed consumption.L-Glutamine（GLN） is an important source of fuel for intestinal epithelial *** objective of this study was to determine the impact of creep feeding and adding GLN or AminoGut（AG;containing glutamine ＋ glutamate） to pre-and post-weaning diets on pig performance and intestinal ***（N = 120） were allotted to four treatments during 14–21 d of lactation： 1） No creep feed（NC,n = 45）;2） creep fed control diet（CFCD,n = 45）;3） creep fed 1% GLN（CFGLN,n = 15）;4） creep fed.88% AG（CFAG,n = 15）.After weaning,the NC and CFCD groups were sub-divided into three groups（n = 15 each）,receiving either a control nursery diet（NC-CD,CFCD-CD） or a diet supplemented with either GLN（NC-GLN,CFCD-GLN） or with AG（NC-AG,CFCD-AG）.Litters that were creep fed with diets containing GLN or AG also were supplemented with those amino acids in the nursery diets（CFGLN-GLN,CFAG-AG）.Glutamine was added at 1% in all three post-weaning diet phases and AG was added at.88% in phase 1 and 2 and at.66% in phase ***： Feed conversion（feed/gain） showed means among treatment means close to significance（P = 0.056） and Tukey＇s test for pairwise mean comparisons showed that Pigs in the CFGLN-GLN group had the best feed conversion（feed/gain） in the first three-week period post-weaning,exceeding（P = 0.044） controls（CFCD-CD） by 34%.The NC-AG group had（P = 0.02） the greatest feed intake in the last three week of the study,exceeding controls（CFCD-CD） by 12%.CFGLN-GLN,CFCD-GLN and sow reared（SR） pigs had the greatest（P = 0.049） villi height exceeding the CFCD-AG group by 18%,20% and 19% *** CFAG-AG group had the deepest（P = 0.001） crypts among all ***-GLN,CFCD-GLN and SR groups had the greatest（P = 0.001） number of cells proliferating（PCNA） exceeding those in the NC-CD group by 43%,54% and 63% *** reared pigs showed the greatest（P = 0.001） intestinal absorption capacity for xylose and

关键词： Creep feeding Glutamine Growth performance Intestinal health SEM villi

CXCL12/CXCR4 Expression in Trophoblasts Takes Part in Materno-fetal Immune Tolerance and Vascular Remodeling

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2006年第4期26卷 466-468页

作者：杨昀邹丽李梅赵茵 Department of Obstetrics and Gynecology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Summary： In this study, we investigated the expression of CXCL12 （SDF-1）/CXCR4 in trophoblasts and the role they play in the gestation. Immunochemistry was used to detect the expression of CXCR4 and CXCLI 2 in human villi and placenta. Highly purified extra-viUous trophoblasts （EVTs） ere detected for CXCR4 and CXCL12 in vitro by immunocytochemistry. The chemotaxis of CXCL12 was tested in transweU and the chemotactic activity was quantitatively examined. It was suggested that both CXCR4 and CXCL12 were expressed in trophoblasts and were decreased with the gestation time P〈0.05）. In a certain coverage, CXCL12 exhibited chemotactic activity which was positively correlated with its concentration [（r）=0.68, P〈0.01], the maximum chemotactic index （CI） was 1.62±0.12. Our results suggest that interaction between CXCR4 and CXCL12 is involved in materno-fetal immunological tolerance in all three trimesters of gestation and contributes to the invasion of EVTs during pregnancy.

关键词： chemokine chemokine receptor villi placenta extra-villous trophoblasts

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中西医结合治疗小儿肺炎96例

内蒙古中医药 1994年第S1期13卷 91-,110页

作者：赵永胜韩志远降永胜达茂旗医院中医科

中西医结合治疗小儿肺炎９６例赵永胜，韩志远，降永胜达茂旗医院中医科（０１２０００）１９９１年１０月２０日收稿自１９８９年１０月以来，笔者采用中西医结合方法，以中医辨证论治为主，结合西药对症治疗小儿肺炎９６例，疗效满意... 详细信息

中西医结合治疗小儿肺炎９６例赵永胜，韩志远，降永胜达茂旗医院中医科（０１２０００）１９９１年１０月２０日收稿自１９８９年１０月以来，笔者采用中西医结合方法，以中医辨证论治为主，结合西药对症治疗小儿肺炎９６例，疗效满意，现介绍如下：１临床资料９６例小儿...

关键词： placental villi early pregnancy, ultrastructure

The physiological characteristics of the basal microvilli microvessels in pancreatic cancers

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解剖学杂志 2021年第S1期44卷 202-202页

作者： Ma Lixiang Chen Xinyu Hexige Saiyin Department of Anatomy Histology&EmbryologySchool of Basic Medical SciencesFudan UniversityShanghai 200032 Shanghai State Key Laboratory of Genetic Engineering Institute of GeneticsSchool of Life SciencesFudan University

Pancreatic cancer(PC)is a highly lethal tumor with controversial high glucose uptake and ***,the hypomicrovasculature,which is considered to have poor perfusion,blocks the delivery of drugs to ***,we described the preferential existence of a novel endothelial projection with trafficking vesicles in PCs,referring to basal ***,whether the basal microvilli microvessels have good perfusion or deliver nutrients to the tumor milieu is ***,we perfused multiple endothelial markers and nutrients to autochthonous PC-bearing mice to study the nutrient trafficking and perfusion status of the basal microvilli microvasculature.

关键词： villi drugs fused

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HEMOPOIETIC SYSTEM

China Medical Abstracts(Internal Medicine) 1994年第4期11卷 218-222页