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Expression of gastrointestinal nesfatin-1 and gastric emptying in ventromedial hypothalamic nucleus- and ventrolateral hypothalamic nucleus-lesioned rats

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World Journal of Gastroenterology 2014年第22期20卷 6897-6905页

作者： Zi-Bin Tian Run-Jun Deng Gui-Rong Sun Liang-Zhou Wei Xin-Juan Kong Xue-Li Ding Xue Jing Cui-Ping Zhang Yin-Lin Ge Department of Gastroenterology Affiliated Hospital of Medical College of Qingdao University Clinical Laboratory Affiliated Hospital of Medical College of Qingdao University Department of Biochemistry and Molecular Biology Medical College of Qingdao University

AIM: To determine the expression levels of gastrointestinal nesfatin-1 in ventromedial hypothalamic nucleus (VMH)-lesioned (obese) and ventrolateral hypothalamic nucleus (VLH)-lesioned (lean) rats that exhibit an imba... 详细信息

关键词： Nucleobindin Nesfatin-1 Gastrointestinal tract Gastric emptying ventromedial hypothalamic nucleus Hyperphagia Obesity Anorexia

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Study on Action of Acupuncture on ventromedial nucleus of Hypothalamus in Obese Rats

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Journal of Traditional Chinese Medicine 2001年第3期21卷 220-224页

作者：刘志诚孙凤岷苏静赵玫朱苗花王沂争魏群利李嘉顾云王友京 The Second Clinical Medical College of Nanjing University of Traditional Chinese Medicine and Pharmacy Nanjing 210029 Nanjing College of Population Administration Cadres

Effects of acupuncture on the spontaneous discharge of nerve cells and levels of monoamine neurotransmitters in ventromedial nucleus of hypothalamus (VMH) of the obese rats were investigated. Results indicated that the levels of tyrosine (Tyr) and dopamine (DA) were lowered, the levels of 5-hydroxytryptamine (5-HT) and 5-hydoxyindole acetic acid (5-HIAA) increased, and the frequency of the spontaneous discharge of nerve cells in VMH lowered in the obese rat group as compared with the normal group. When acupuncture obtained the effect of weight reduction, the frequency of spontaneous discharges of nerve cells in VMH were markedly increased, and the levels of Tyr, DA and tryptamine (Typ) and 5-HT/5-HIAA ratio elevated, and the 5-HT level lowered. It is suggested that the virtuous regulative action of acupuncture on VMH might be one of the key factors in acupuncture for weight reduction.

关键词： Acupuncture Animals Dopamine Hypothalamus Male Obesity Random Allocation Rats Rats, Sprague-Dawley Serotonin Tyrosine ventromedial hypothalamic nucleus

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Cerebellar fastigial nuclear inputs impinge on feeding-related neurons in ventromedial hypotha-lamic nucleus in rats

Cerebellar fastigial nuclear inputs impinge on feeding-relat...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者： Bin Li Qian-Xing Zhuang He-Ren Gao Jing-Ning Zhu Jian-Jun Wang School of Life Sciences Nanjing University

The ventromedial hypothalamic nucleus（VMN）has traditionally been implicated in feeding behavior,energy balance,and body weight *** studies have indicated that neurons in the VMN receive various peripheral feeding-related signals,such as the gastric vagal inputs,blood glucose,and ghrelin,a peptide primarily produced in the stomach and stimulating both feeding and growth hormone ***,the cerebellum,a classic subcortical somatic motor center,participates in regulation of nonsomatic visceral activities including food intake via the direct cerebellohypothalamic ***,by using anterograde axonal tract tracings and extracellular recordings in vivo in rats,the present study was designed to investigate whether the outputs of cerebellar fastigial nucleus（FN）could reach and converge with the feeding-related gastric vagal,glycemia and ghrelin signals onto single VMN ***,anterograde tracers,biotinylated dextran amine（BDA）and Phaseolus vulgaris-leucoagglutinin（PHA-L）,were injected into the cerebellar FN and nucleus tractus solitarius（NTS）,a critical relay nucleus in the pathway transmitting information from the gastric vagal nerves to VMN,*** results show that both the projections of cerebellar FN and NTS reach and converge onto single glucose-sensitive neurons in the ***,of the 179 VMN neurons recorded,97（97/179,54.2%）responded to the cerebellar FN stimulation,in which 85（85/97,87.6%）were also responsive to gastric vagal stimulation,suggesting a convergence of cerebellar FN and gastric vagal inputs on the VMN ***,a summation of responses was observed（n=7）when the cerebellar FN and gastric vagal nerve were simultaneously *** the 22 VMN neurons responsive to both the cerebellar FN and gastric vagal stimulations,16（72.7%）cells also responded to the systemic administrations of glucose and *** results demonstrated that the somatic information forwarded by the cerebel

关键词： cerebellar fastigial nucleus ventromedial hypothalamic nucleus ghrelin somatic-visceral integration

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The Time-Effect Relationship of Central Action in Acupuncture Treatment for Weight Reduction

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Journal of Traditional Chinese Medicine 2000年第1期20卷 26-29页

作者：赵玫刘志诚苏静王友京 The Second Clinical College of Nanjing University of Traditional Chinese Medicine and Pharmacy Nanjing 210029 Chinese PLA Air Force 454 Hospital Nanjing 210002

Purpose: To study the time-effect relationship of action of acupuncture on the satiety center of ventromedial nucleus of hypothalamus (VMH) in rats with experimental obesity. Methods: Microelectrode recording method of nerve cells and stereotaxic technique for brain were adopted with discharge frequency (Hz/s) of nerve impulse in VMH as the index, and the time-effect of acupuncture action in different periods between groups were observed. Results: Electric activity in acupuncture group was higher than that in the obesity model group (P<0.001) and the normal group (P<0.01) respectively, and the curve of acupuncture action within 2 hours showed irregular fluctuation. Conclusion: Acupuncture can increase excitability of the satiety center, with a better long-term effect.

关键词： Acupuncture Therapy Electroacupuncture Weight Loss Animals Electrophysiology Male Obesity Random Allocation Rats Rats, Sprague-Dawley Time Factors ventromedial hypothalamic nucleus

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