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Monkeypox virus(MPXV):A Brief account of global spread,epidemiology,virology,clinical features,pathogenesis,and therapeutic interventions

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Infectious Medicine 2023年第4期2卷 262-272页

作者： Md Aminul Islam Jubayer Mumin Md Masudul Haque MdAzizul Haque Ahrar Khan Prosun Bhattacharya Md Atiqul Haque Advanced Molecular Lab Department of MicrobiologyPresident Abdul Hamid Medical CollegeKarimganj 2310Bangladesh COVID-19 Diagnostic Lab Department of MicrobiologyNoakhali Science and Technology UniversityNoakhali 3814Bangladesh Department of Global Public Health Karolinska InstitutetSE-17177 StockholmSweden Department of Public Health North South UniversityDhaka 1229Bangladesh Department of Biochemistry and Molecular Biology Faculty of AgricultureHajee Mohammad Danesh Science and Technology UniversityDinajpur 5200Bangladesh Shandong Vocational Animal Science and Veterinary College Weifang 261061China COVID-19 Research@KTH Department of Sustainable DevelopmentEnvironmental Science and EngineeringKTH Royal Institute of TechnologySE-10044 StockholmSweden Key Laboratory of Animal Epidemiology and Zoonoses of Ministry of Agriculture College of Veterinary MedicineChina Agricultural UniversityBeijing 100019China Department of Microbiology Faculty of Veterinary and Animal ScienceHajee Mohammad Danesh Science and Technology UniversityDinajpur 5200Bangladesh

The largest monkeypox virus(MPXV)outbreak of the 21st century occurred in 2022,which caused epidemics in many *** to WHO,physical contact with infected persons,contaminated surfaces,or affected animals might be a source of this virus transmission.A febrile sickness including few symptoms found in MPX *** rash,lesions,fever,headache,fatigue,and muscle aches symptoms were observed commonly for this *** and in vitro,studies have shown that the antiviral medications cidofovir and brincidofovir are effective against *** first-generation vaccinia virus vaccine was developed in 1960,and it helped to protect against MPXV with its side effects.A second-generation vaccination with limitations was launched in ***,the CDC advised vaccinations for risk groups in endemic countries,including positive patients and hospital *** JYNNEOS vaccine,administered in 2 doses,also provides protection from *** article presents concisely the most recent findings regarding epidemiology,genomic transmission,signs and symptoms,pathogenesis,diagnosis,and therapeutic interventions for MPXV,which may be helpful to researchers and *** declared that MPX was no longer a global health emergency due to its declining case rate,and a number of countries have reported new *** research-based investigations must be carried out based on the 2022 outbreak.

关键词： Monkeypox(MPX) Monkeypox virus(MPXV) Epidemiology Zoonotic diseases Re-emerging viruses Genomic dissemination vaccination and treatment

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Optimal control strategies for preventing hepatitis B infection and reducing chronic liver cirrhosis incidence

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Infectious Disease Modelling 2020年第1期5卷 91-110页

作者： Mst.Shanta Khatun Md.Haider Ali Biswas Mathematics Discipline Science Engineering and Technology SchoolKhulna UniversityKhulna9208Bangladesh

Advanced liver cirrhosis has become life-threatening among non-communicable diseases ***,the terminal stage of liver diseases in which the liver develops scarring as a result of various long-term continuous *** liver diseases,viral hepatitis is the major risk factor for chronic cirrhosis *** present paper demonstrates a compartmental model of chronic disease liver cirrhosis describing the transmission dynamics of this *** the Pontryagin’s maximum principle,the optimal control policies such as vaccination for hepatitis B virus and treatment of other causes of cirrhosis are adopted as control *** target of this study is to minimize the number of infected and liver cirrhotic individuals as well as the associated cost of the *** this purpose,the optimal control strategies are employed according to the underlying causes behind this *** goal is to find the strategy of preventing hepatitis B infection which is considered one of the leading causes of cirrhosis and consequently,reduction of the chronic cirrhosis *** analysis is also performed to observe the effective control among the two control *** model is investigated both analytically and numerically and the numerical simulations are carried out to illustrate the analytical *** analysis reveals that both the vaccination and treatment could be the most fruitful way to reduce the incidence of chronic liver cirrhosis.

关键词： Liver cirrhosis Hepatitis B infection vaccination and treatment Optimal control Maximum principle Efficiency analysis

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