检索结果-南通市图书馆

Is There Any Impact of vdr Gene polymorphism in Bataks Ethnic to Have Tuberculosis？

Journal of Health Science 2017年第1期5卷 1-8页

作者： Yahwardiah Siregar Bintang Y.M. Sinaga Department of Biochemistry Faculty of Medicine Universitas Sumatera Utara Medan Indonesia Department of Pulmonology and Respiratory Faculty of Medicine Universitas Sumatera Utara--Adam Malik Hospital MedanIndonesia

The active metabolite of vitamin D activates macrophages and results in the restriction of growth of Tuberculosis （TB） pathogen M. tuberculosis. The effect of vitamin D is achieved through binding to the Vitamin D Receptor （vdr）, which ultimately produces the antimicrobial peptide Cathelicidin. Matched case-control study with 76 pulmonary tuberculosis Indonesian Batak ethnic patients and 76 healthy normal control were completed. Genetic polymorphisms of vdr gene were analysed using PCR and RFLP. The genotype frequencies of ApaI were AA 10.6%, Aa 44.7%, aa 44.7% for the control group and AA 10.6%, Aa 43.4%, aa 46% for the PTB patients. For the Fokl genotype the frequencies were FF 39.5%, Ff 44.7%, ff 15.8% for the control group and FF 35.5%, Ff 55.3%, ff9.2% for the PTB patients. In these two genotypes there were no significant differences found between the control group and the PTB patients （P 〉 0.05）. Besides, there genotypic frequencies were in agreemem with the Hardy-Weinberg Equilibrum （P 〉 0.05）. However, for the BsmI genotype frequencies, BB 2.6%, Bb 23.7% and bb 73.7% for the control group and BB 0%, Bb 68.4%, bb 31.6% for the PTB patients, there was a significant association found with PTB; the bb genotype is correlated with a decreased risk for PTB （OR 0.22, 95% CI： 0.11-0.45）. ApaI and Fokl polymorphisms ofvdr gene do not appear to be responsible for host susceptibility to pulmonary tuberculosis in the Indonesian Batak ethnic population but BsmI polymorphism had association with host resistant to PTB.

关键词： Pulmonary tuberculosis vdr polymorphism Batak Indonesia.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immunohistochemical evaluation of vitamin D receptor(vdr) expression in cutaneous melanoma tissues and four vdr gene polymorphisms

引用

Cancer Biology & Medicine 2017年第2期14卷 162-175页

作者： Francesco La Marra Giuseppe Stinco Cinzia Buligan Giovanni Chiriacò Diego Serraino Carla Di Loreto Sabina Cauci Department of Medical Area School of MedicineUniversity of Udine Dermatology Clinic Udine University-HospitalUniversity of Udine Unit of Cancer Epidemiology CRO Aviano National Cancer Institute

Objective:Vitamin D receptor(vdr)mediates vitamin D *** examined whether vdr expression in excised melanoma tissues is associated with vdr gene(vdr)***:We evaluated vdr protein expression(by monoclonal antibody immunostaining),melanoma characteristics,and carriage of vdr-Fok I-rs2228570(C>T),vdr-Bsm I-rs1544410(G>A),vdr-ApaI-rs7975232(T>G),and vdr-TaqI-rs731236(T>C)polymorphisms(by restriction fragment length polymorphism).Absence or presence of restriction site was denoted by a capital or lower letter,respectively:"F"and"f"for Fok I,"B"and"b"for Bsm I,"A"and"a"for ApaI,and "T"and"t"for TaqI ***-four Italian cutaneous primary melanomas(52.1±12.7 years old)were studied;51.4% were stage Ⅰ,21.6% stage Ⅱ ,13.5% stage Ⅲ,and 13.5% stage Ⅳ *** expression was categorized as follows:100% positive vs.vdr expression)vs.≤20%(low vdr expression);absence *** of vdr-expressing ***:Stage I melanomas,Breslow thickness ofvdr *** genotypes BbAA,bbAa,AATt,BbAATt,and bbAaTT were more frequent in 100%vs.vdr-expressing *** genotype AATT was more frequent in melanomas lacking vdr expression(odds ratio=14.5;P=0.025).vdr expression was not associated with metastasis,ulceration,mitosis>1,regression,tumor-infiltrating lymphocytes,tumoral infiltration of vascular tissues,additional skin and non-skin cancers,and melanoma ***:We highlighted that vdr polymorphisms can affect vdr expression in excised melanoma *** vdr expression in AATT carriers is a new finding that merits further *** expression possibly poses implications for vitamin D supplementation against *** expression and vdr genotype may become precise medicinal tools for melanoma in the future.

关键词： Vitamin D receptor vdr protein expression vdr polymorphism cutaneous melanoma metastatic melanoma skin cancer predictive biomarkers FokI polymorphism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association between vitamin D receptor polymorphisms and multiple sclerosis： systematic review and meta-analysis of case-control studies

引用

Cellular & Molecular Immunology 2015年第2期12卷 243-252页

作者： Kalthoum Tizaoui Wajih Kaabachi Agnes Hamzaoui Kamel Hamzaoui Tunis EI Manar University Faculty of Medicine Tunis Division of Histology and Immunology. Department of Basic Sciences Tunis Tunisia Abderrahman Mami Hospital Pneumology Service Pavilion B Ariana Tunisia

Vitamin D receptor （vdr） polymorphisms have been studied as potential contributors to multiple sclerosis （MS）. However, published studies differ with respect to study design and the significance of the effects detected. The aim of this study was to quantify the magnitude of the risk associated with the Taql, Bsml, Apal and Fold vdr polymorphisms in MS using a meta-analysis approach. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a systematic search and meta-analysis of the literature. Subgroup analyses were performed to detect potential sources of heterogeneity from the selected study characteristics. The stability of the summary risk was evaluated using sensitivity analyses. The meta-analysis included a total of 3300 cases and 3194 controls from 13 case- control studies. There were no significant associations found between Taql and Bsml polymorphisms and MS risk. The association between the Apal polymorphism and MS risk was significant in the homozygous and codominant models （P=0.013 and P=0.031, respectively）, suggesting that the AA Apal genotype might be a significant MS risk factor. Publication year and age significantly affected the association between Taql polymorphisms and MS （P=0.014 and P=0.010, respectively）, which indicates a protective effect of the major T allele. The AA Apal and FF Fold genotypes are significant risk factors for MS. The association between the Taql polymorphism and MS risk is significantly affected by study characteristics.

关键词： Apal Bsml Fokl meta-analysis multiple sclerosis Taql vdr polymorphism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bsm I(rs1544410) and Fok I(rs2228570) vitamin D receptor polymorphisms, smoking, and body mass index as risk factors of cutaneous malignant melanoma in northeast Italy

引用

Cancer Biology & Medicine 2017年第3期14卷 302-318页

作者： Sabina Cauci Vincenzo Maione Cinzia Buligan Martina Linussio Diego Serraino Giuseppe Stinco Department of Medicine University of UdineUdine 33100Italy Dermatology Clinic University Hospital of Brescia Brescia 25123Italy Dermatology Clinic University Hospital of UdineUdine 33100Italy Unit of Cancer Epidemiology CRO Aviano National Cancer InstituteAviano 33081Italy

Objective:To investigate whether vitamin D receptor gene(vdr)Bsm I-rs1544410 and Fok I-rs2228570 polymorphisms,smoking duration,and body mass index(BMI)are risk factors for cutaneous melanoma,especially metastatic ***:We studied 120 cutaneous melanoma cases[68 stage I and II non-metastatic melanoma(NMet M)patients,plus 52Stage III and IV metastatic melanoma(Met M)patients],and 120 matching healthy controls from northeast *** polymorphisms were measured by restriction fragment length polymorphism *** or presence of Bsm I and Fok I restriction sites was denoted by"B"and"F"or by"b"and"f,"***:vdr-Bsm I bb genotype was more frequent among Met M(32.7%)than among NMet M cases(13.2%),with odds ratio(OR)=*** of all melanoma patients vs healthy controls showed that the following biomarkers were at risk:≥20 years of smoking(OR=2.43);≥20 years of smoking combined with bb(OR=4.78),Bb+bb(OR=2.30),Ff(OR=3.04),and Ff+ff(OR=3.08);obesity(BMI>30Conclusions:Risk factors for cutaneous Met M include two vdr polymorphisms combined with smoking duration and *** suggest gene-environment implications in melanoma susceptibility and *** studies in larger cohorts and in subjects with different genetic background are warranted to extend our findings.

关键词： Vitamin D receptor vdr polymorphism cutaneous melanoma metastatic melanoma smoking body mass index obesity skin cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：