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Molecular Docking Studies of Botanical Beverage Mix Berries (LIFEGREENTM) against Breast Cancer Cells from Targeted Protein 1QQG, 7B5Q & 7B5O & uterine fibroid from Targeted Protein 2AYR, 6T41 & 3GRF

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Computational Molecular Bioscience 2024年第2期14卷 59-123页

作者： Ummi Shahieda Lazaroo Bt Zurrein Shah Lazaroo Navanithan Sivanananthan Chua Kia How Department of Scientific Research of Lifetree Asia Sdn Bhd Selangor Malaysia Department of Scientific Research of Lifetree Biotech Sdn Bhd Selangor Malaysia Department of Research and Development of Nutrimedt Sdn Bhd Selangor Malaysia Faculty of Health & Life Sciences Management & Science University Selangor Malaysia Lifetree Asia Sdn Bhd Selangor Malaysia Lifetree Biotech Sdn Bhd Selangor Malaysia Nutrimedt Sdn Bhd Selangor Malaysia

fibroids, also called leiomyomas or myomas, are communal tumors of the muscle or uterine wall that affect about 20% of females who are of reproductive age. They can look as if singly or in clusters, and they often cease to grow after menopause. fibroids can be classified as intramural, sub serosal, pedunculated, or submucosal based on where they are positioned in the uterus. Although fibroids are benign, they can grow quickly and cause a range of symptoms, such as pelvic pressure, heavy menstrual flow, and infertility. As a result, fibroids are a main reason behind hysterectomy surgeries. The majority of cases of breast cancer are ductal and lobular cancers, making it the second utmost common cancer in women international. Gene mutations like those in BRCA1 or BRCA2 knowingly raise the risk of breast and other cancers, typically with an earlier cancer onset. Cancer risk is influenced by a complex interplay of genetic abnormalities, environmental factors, and lifestyle selections. Further research into these relations is domineering. Although they are common in uterine leiomyomas, especially multiple leiomyomas, MED12 mutations do not significantly correlate with tumor size. These mutations have also been noticed in smooth muscle tumors and leiomyosarcomas, two other types of uterine cancer. The identification of MED12 mutations as the sole genetic abnormality originates in leiomyomas raises the opportunity of a role in the genesis of cancer. 10% - 15% of women who are of reproductive age have endometriosis, which grants serious difficulties because of its chronic nature and range of clinical symptoms. Even after effective surgeries, issues reoccur often, adding to the enormous financial burden. The effects of MED12 mutations have been experiential in recent studies examining the molecular causes of endometriosis-associated infertility, which have shown anomalies in cellular connections and signaling cascades. Computational techniques were used in this study to inves

关键词： uterine fibroid Breast Cancer Molecular Docking IRS Protein BRCA1 BRCA2 MED12-a Endometriosis

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Laparoscopic myomectomy versus open myomectomy in uterine fibroid treatment: A meta-analysis

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第3期4卷 66-71页

作者： Probo Yudha Pratama Putra Arlinda Silva Prameswari Mochammad Ma'roef Aida Musyarrofah Halida Nelasari Medical Faculty University of Muhammadiyah MalangMalangIndonesia Department Obstetric and Gynecology Medical FacultyUniversity of Muhammadiyah MalangMalangIndonesia Department Obstetric and Gynecology General Hospital of University Muhammadiyah MalangMalangIndonesia

Objective:uterine fibroids are the most commonly occurring benign solid tumors in women,and laparoscopic or open myomectomy constitutes the primary option for ***,both methods are under debate currently in terms of efficacy and *** this meta-analysis we assessed the efficacy and safety of the two ***:We conducted a comprehensive literature search of PubMed,ScienceDirect,and the Cochrane Library in December *** search terms included“open myomectomy”,“myomectomies”,“laparoscopic”,and“uterine fibroids”.We then selected the randomized control trials published from 1996 to 2019 and compared laparoscopic and open ***:We included 10 studies of 449 patients who underwent laparoscopic myomectomy and 449 patients who underwent open *** data revealed that laparoscopic myomectomy was associated with reduced blood loss(MD=-34.43;95%CI,-34.92 to-33.94;puterine fibroids(OR=1.15;95%CI,0.60 to 2.18;p=0.67)between the two ***:Laparoscopic myomectomy displayed superior results compared to open myomectomy,although the former involved a longer operating time.

关键词： uterine fibroid Laparoscopic myomectomy Open myomectomy

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Associated Factors and Consequences of uterine fibroids in Hospitals in the Borgou Department of Benin in 2022

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Advances in Reproductive Sciences 2024年第1期12卷 60-74页

作者： Mahublo Vinadou Vodouhe Sedjro Raoul Atade Yèyinou Aurelle Ahouingnan Bernard Agossou Bernard Akouodé Thomas Hounto Goudi Orou Bodedjo Nouessèwa Fanny Maryline Hounkponou Ahouingnan Kabibou Salifou Department of Mother and Child Faculty of Medicine University of Parakou Parakou Benin

Introduction: uterine fibroids are the most common gynecological tumors in women of childbearing age and have multiple clinical manifestations. Objective: To determine factors associated with uterine fibroids in the Borgou department of Benin in 2022. Method: Descriptive, analytical cross-sectional study from August 22 to September 22, 2022. The sample consisted of women consulting for gynecological problems in 6 hospitals in the Borgou department in the North of Benin. Results: Of the 744 women surveyed, 10.1% were diagnosed with uterine fibroids. Women with uterine fibroids were often married, paucigesture, and nulliparous. Their main reasons for consultation were the desire for motherhood (50.7%), pelvic pain (46.7%), and genital hemorrhage (14.7%). Age, history of miscarriage, high blood pressure, and diabetes were significantly associated with the presence of uterine fibroids (Conclusion: uterine fibroids are common in hospitals in northern Benin. There were factors associated with them that should be taken into account in management strategies.

关键词： uterine fibroid Associated Factor Consequence Benin

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Analysis of the Effect of Comfort Care in The Perioperative Care of Patients with Hysteromyomectomy and its Influence on Self-Care Ability

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Journal of Clinical and Nursing Research 2024年第4期8卷 116-121页

作者： Yi Yuan Zhonglu Huang Meishan Women and Children’s Hospital Alliance Hospital of West China Second University HospitalSichuan UniversityMeishan 620000Sichuan ProvinceChina

Objective:To analyze the effect of perioperative comfort care for patients with hysteromyomectomy(HYS).Methods:Seventy cases of HYS patients admitted to our hospital from October 2022 to October 2023 were randomly selected and divided into Group A(control group,35 cases,conventional care)and Group B(observation group 35 cases,comfort care).The effects of the two groups before and after nursing care were ***:The self-rating anxiety(SAS)scores,exercise of self-care agency(ESCA)scores,and nursing satisfaction scores at the time of discharge of Group B were better than in Group A after nursing care(P<0.05).Conclusion:Perioperative comfort care for HYS patients improved the patient’s adverse emotions,self-care ability,and nursing satisfaction.

关键词： uterine fibroid Perioperative nursing Comfort nursing Self-care ability

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CT-Monitored Percutaneous Cryoablation of uterine fibroids after uterine Artery Embolization

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Chinese Journal of Clinical Oncology 2007年第4期4卷 241-245页

作者： Zizhuo Zhao Zhi Guo Hona Ni Fang Liu Baoguo Li Department of Interventional Radiology Tianjin Medical University Cancer Institute ＆ Hospital Tianjin 300060 China.

OBJECTIVE To investigate the effects of percutaneous cryoablation on uterine fibroids using computed tomographic （CT） guidance after uterine artery embolization.METHODS Twelve patients who failed to respond to uterine artery em- bolization were treated using percutaneous cryoablation. All patients had undergone previous uterine artery embolization an average of 1.2 years （0.7-1.6 years） ago. Two cases had abnormal bleeding, and the other 10 suffered from pressure and/or pelvic pain. Myoma diameters were 4 cm to 16.5 cm. By using CT guidance, 2.0, 2.4, 3.0 or 3.8 mm cryoprobes were placed into the fibroid, and two 15-20 rain freezing processes were performed. Hemostasis was achieved only by pressing the incisions for several minutes. MR-imaging was performed before the procedure to measure the size and number of fibroid tumors, and follow- up MR-imaging determined the reduction of the lesions.RESULTS All patients were discharged within 48 h of treatment. Almost no hemorrhage was found in all of the cases. No bladder or bowel injury or significant postsurgery pain was reported. Ice spheres were readily visualized at CT. Beam-hardening artifact from the metal probes was present, but did not interfere with the procedure. Myomas regressed up to 76.3% after 12 months of treatment, and the primary symptoms improved in all treated women.CONCLUSION CT-monitored percutaneous cryoablation is an effective and minimally invasive therapy for symptom relief and fibroid shrinkage after the failure of uterine artery embolization.

关键词： cryotherapy uterine fibroid computed tomography (CT) uterine artery embolization.

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Surgical Management of uterine fibroids: About 175 Cases

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Open Journal of Obstetrics and Gynecology 2023年第3期13卷 481-489页

作者： Ngom Papa Malick Faye Marie Edouard Gaye Yaye Fatou Sylla Mafing Aya Niang Ndama Samb Abdoulaye Ndiogou Bentaleb Hajar Inzale Mohamed Amine Koné Madjiguène Department of Obstetrics Gynecology Hospital Principal Dakar Dakar Senegal Department of Anesthesia Hospital Principal Dakar Dakar Senegal

Background: uterine fibroids are a common condition in Senegal and often symptomatic. Our study aims to determine the epidemiological profile, to clarify the diagnostic aspects and to evaluate the surgical management of patients with uterine fibroids. Patients and Method: We carried out a retrospective and descriptive study carried out over a period of 30 months, from August 1, 2017 to January 31, 2020, concerning all patients who underwent surgery for the treatment of uterine myomatosis in the department of Gynecology Obstetrics of the Hospital Principal of Dakar. The data was collected from the patients’ medical records and analyzed using Excel version 2016 and R version 4 software. Results: We collected 175 surgical interventions for uterine fibroids, representing 44.7% of gynecological interventions. Most of the patients were between 30 and 39 years old, with an average age of 39 years. The nulliparous were the majority with 64.6%. The clinical symptomatology was represented by genital bleeding (32.6%), pelvic pain (18.85%) and infertility (12.6%). The diagnosis was confirmed by pelvic ultrasound in all patients with variable myoma topography. A myomectomy was performed in 82.3% of cases and a total hysterectomy in 17.7%. The postoperative course was simple in 94.2% of cases, and the results of treatment revealed a disappearance of symptoms in 94.3% of cases. Conclusion: Surgery occupies a prominent place in the management of uterine fibroids.

关键词： uterine fibroid Myomectomy Pelvic Ultrasound

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Analysis of the Status Quo and Influencing Factors of Readiness for Hospital Discharge of Patients Undergoing Hysteromyomectomy

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Yangtze Medicine 2020年第3期4卷 173-182页

作者： Liu Zhang Gaijing Wang Ting Cai Yanling Heng Department of Medicine Yangtze University Jingzhou China

Objective: To evaluate the status quo and influencing factors of readiness for hospital discharge of patients undergoing hysteromyomectomy. Methods: A total of 240 patients with uterine fibroid undergoing hysteromyomectomy from 2 hospitals in Jingzhou were investigated using a self-designed general information questionnaire, the Readiness for Hospital Discharge Scale and the Quality of Discharge Teaching Scale. Results: The total score of readiness for hospital discharge was (91.36 ± 18.46), the multiple linear regression analysis showed that the quality of discharge guidance, the scope of myomectomy, pain degree of incision and the average monthly income per family were the main influencing factors of readiness for hospital discharge. Conclusion: The readiness for hospital discharge was at a medium level in patients with uterine fibroid undergoing hysteromyomectomy, medical personnel should give specific discharge guidance according to the specific conditions of patients to ensure the safety of patients after discharge.

关键词： uterine fibroid Readiness for Discharge Discharge Teaching Influencing Factors

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A Case Report on Pulmonary Benign Metastasizing Leiomyoma with Recurrent uterine fibroids

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Proceedings of Anticancer Research 2022年第5期6卷 91-96页

作者： Zheng Gong Zegang Liu Department of Thoracic Surgery The Affiliated Hospital of Yunnan UniversityKunming 650021Yunnan ProvinceChina Department of General Surgery 920 Hospital of the Joint Service Support Force of the Chinese People’s Liberation ArmyKunming 650021Yunnan ProvinceChina

Pulmonary benign metastasizing leiomyoma(PBML)is a type of benign metastasizing leiomyoma(BML),which metastasizes to *** view of the rarity and nonspecific imaging characteristics of PBML,this condition is easily misdiagnosed as malignant lung *** is a case report of a 39-year-old lady in whom multiple bilateral lung nodules were found during a health checkup and was diagnosed with *** patient had recurrent uterine fibroids and underwent myomectomy twice,7 years and 3 years ago,respectively,before the diagnosis of PBML was *** patient was asymptomatic,and regular examinations were *** laboratory investigations were all within normal *** tomography(CT)showed multiple nodules in bilateral *** order to confirm the disease,thoracoscopic nodule resection and tissue biopsy were *** eosin(HE)staining showed spindle-shaped cells,while immunohistochemical staining revealed positive for desmin,smooth muscle actin(SMA),estrogen receptor(ER),and progesterone receptor(PR),which are all PBML *** patient was followed-up without any further *** 8 months of follow-up,CT scan revealed an increased number of *** is unique case because of the recurrence of uterine fibroids,which means that the patient is susceptible to *** report may give a new insight to the relationship between the susceptibility of uterine fibroids and the onset and progression of PBML.

关键词： Pulmonary benign metastasizing leiomyoma(PBML) Benign metastasizing leiomyoma(BML) Myomectomy uterine fibroid

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