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Harnessing macrophages in thermal and non-thermal ablative therapies for urologic cancers-Potential for immunotherapy

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Laparoscopic, Endoscopic and Robotic Surgery 2018年第1期1卷 5-11页

作者： Vinodh-Kumar-Adithyaa Arthanareeswaran Mandy Berndt-Paetz Roman Ganzer Jens-Uwe Stolzenburg Abinaya Ravichandran-Chandra Annegret Glasow Jochen Neuhaus Department of Urology University Hospital LeipzigLeipzigGermany Department of Urology Research LaboratoryUniversity of LeipzigLeipzigGermany Asklepios Stadtklinik Bad T€olzGermany Department of Radiation Therapy University of LeipzigLeipzigGermany

Prostate and bladder cancers are one of the cancers occurring *** addition to radical surgery,the past decade has also focused on targeted therapy of overexpressed cancer proteins that are lethal and critical for cancer cell ***,targeted therapy cannot adapt for changing of cancer molecular characteristics and,ultimately,a clone that bypasses the targeted therapy *** can be overcome by *** studies on ablative therapy of cancers show presence of immunomodulatory effect in these *** ablation prime the immune system for further destruction of persistent primary tumor in addition to destruction of concurrent metastatic disease and also reduce *** therapies can achieve a state of increased *** combination with a novel macrophage targeted therapy may enhance immune priming,trafficking,and/or effector phases;thereby improving clinical *** associated macrophages or M2 phenotype are now known to mediate this immunosuppressive pro-tumorigenic *** of macrophage differentiation may enhance tumor destruction of ablative *** breakthrough in immunotherapy opens up arenas for further robust clinical trials on combinatorial *** the present review,we aim to elucidate the major aspects of immune stimulatory minimal invasive approaches by combining with macrophage directed pathways.

关键词： urologic cancers Macrophage High Intensity Focused Ultrasound Cryotherapy Focal laser ablation Photodynamic therapy Anti PD-L1 antibody Agonist CD40 antibody

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Adult urological cancers at Zinder National Hospital

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Open Journal of Urology 2024年第5期14卷 267-276页

作者： Halidou Maazou Manzo M. S. Ousmane Chaibou Soumana Abdoulaye Kodo Idrissa Seriba Abdoulrazak R. H. Zakou Soumana Amadou Department of Urology University of Zinder Zinder Niger Department of Urologie University of Niamey Niamey Niger Department of Mé dicale Oncology National H&#244pital of Zinder Zinder Niger Department of Anatomy Pathology Universit&#233 of Zinder Zinder Niger

The aim of this study was to present the epidemiological, clinical and therapeutic aspects of adult urological cancers in the department of urology at Zinder National Hospital. Patients and Methods: This was a cross-sectional study of adult primary urologic cancers during the period of January 2019 to December 2023. Data were obtained from the record of patients admitted to urology, and the medical oncology department. The parameters studied were;frequency, age, sex, urogenital distribution, anatomopathological type, and therapeutic aspects. Data were recorded on Excel 2013 and analyzed with Epi-info version 7.2.5. Results: Epidemiology: About 289 cancers were diagnosed through 6017 consultations during the period, corresponding to 4.80% of urological pathologies: prostate cancer (n = 221;76.47%), bladder cancer (n = 46;15.92%), kidney cancer (n = 13;04.5%), testis cancer (n = 09;03.11%). Median age of patients was 50.42 years. Prostate cancer: was Adenocarcinoma in 100% (n = 221) with Gleason scores > 7 (77.83%) and prostatique specific antigen (PSA) > 20 ng/ml in 90.04%. Extension evaluation 134 cases (60.63%). Treatment was chirurgical castration in (62.44%) and resistance to castration appeared between 8 and 11 months. Hospital mortality for prostate cancer was 16.29%. Bladder cancer was found in 46 cases with Sex ratio 7/1. Cystoscopy was performed for all. Histology revealed squamous cell carcinoma (n = 41;89.13%), and (n = 5;10.87%) urothelial. Endoscopic resection performed (n = 14;30.43%). Kidney cancers were 13 cases (10 men, 03 women). Nephrectomy was performed in (n = 8;61.54%) cases and Histology revealed renal cell cancer in 76.92%. Testicular cancers were diag 09 cases. History of cryptorchidism was found in 4 cases, 4-year infertility in 3 cases. Orchidectomy was done in all cases. Chemotherapy in 3 cases. Conclusion: urological cancers are frequent, dominated by prostate cancer. The endemicity of bilharziasis has increased squamous cell carcinoma. T

关键词： urologic cancers Epidemiology Histology Zinder

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